
1. J Clin Periodontol. 2020 Apr 21. doi: 10.1111/jcpe.13295. [Epub ahead of print]

Adjunctive effect of mouthrinse on treatment of peri-implant mucositis using
mechanical debridement: a randomized clinical trial.

Philip J(1), Laine ML(2), Wismeijer D(1).

Author information: 
(1)Department of Oral Implantology and Prosthetic Dentistry, Academic Center for 
Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit
Amsterdam, Amsterdam, The Netherlands.
(2)Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), 
University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The
Netherlands.

AIM: To study effect of delmopinol hydrochloride (DEL) in comparison with
chlorhexidine digluconate (CHX) and a placebo (PLA) in addition to non-surgical
mechanical debridement in patients with peri-implant mucositis.
MATERIALS AND METHODS: Eighty-nine patients with at least one implant diagnosed
with peri-implant mucositis were randomly assigned to one of three study groups
(DEL, CHX and PLA). Professional non-surgical mechanical debridement was
performed at baseline. Mouth rinsing was carried out by the patients twice a day 
in addition to their regular oral hygiene practices. Assessments of efficacy were
performed for the primary outcome percentage Implant bleeding on probing sites
(IBOP%) and secondary outcomes the modified Bleeding Index (mBI), modified Plaque
Index (mPI) at 1 and 3 months.
RESULTS: At 3 months there was statistically significant reduction in IBOP% and
mBI within the study groups compared to baseline. However, there was no
statistically significant difference between the study groups at 3 months
follow-up. Moreover, there was a statistically significant difference according
to mPI at 1 month between the chlorhexidine and placebo group (p = 0.004).
CONCLUSIONS: This study confirms that mechanical debridement combined with oral
hygiene instruction is effective in treatment of peri-implant mucositis. The
clinical effects between groups were comparable.

This article is protected by copyright. All rights reserved.

DOI: 10.1111/jcpe.13295 
PMID: 32315444 

