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Clinical trials for Cardiovascular diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44381   clinical trials with a EudraCT protocol, of which   7393   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
    How to search [pdf]
    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    Query did not match any clinical trials.
    These are paediatric studies completed by 26 January 2007, in respect of products authorised in the Community (Article 45 of the Paediatric Regulation (EC) No 1901/2006).
    Note: Advanced search filters for country, trial phase, gender, rare disease, IMP with orphan designation in the indication and age ranges of in-utero, adult or elderly do not apply to these records.
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    Study title: Blockers and hypoglycaemia (assesment of cadioselective and intrinsic sympathometic properties in relation to severity of hypoglycaemia - No author - 1984 (Current Therapeutic Research 36, n° 2, p. 361-373) ; - Publication in Documentation clinique du dossier d'AMM du 30/10/1987 -
    Active substance: ACEBUTOLOL
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    Document reference: 46182
    Study title: Clinical and echocardiographic (echo) long-term follow-up of children with severe hypertension (HT) - Loirat C. et al. - No date (Hopital Bretonneau, INSERM U 120, Paris) ; - Publication in Documentation clinique du dossier d'AMM du 30/10/1987 -
    Active substance: ACEBUTOLOL
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    Document reference: 46183
    Study title: Clinical pharmacology and therapeutic utilization of anti-hypertensive agents in children - Mirkin B.L., Sinaiko - 1977 In : (New M.I., Levine L.S. Juvenile hypertension, pp. 195-218. New-York, Raven Press.) - Publication in expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46184
    Study title: Experience with acebutolol in the treatment of juvenile hypertension - J. Liška et al.- 2005 (VOX PEDIATRIAE – January 2005 – No.1 – Volume 5)
    Active substance: ACEBUTOLOL
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    Document reference: 46185
    Study title: Expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983
    Active substance: ACEBUTOLOL
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    Document reference: 46186
    Study title: La tension artérielle chez l'enfant et l'adolescent. Valeurs rapportées à l'âge et à la taille chez 17.067 sujets - André J.L., Deschamps J.P., Gueguen R. - 1980 (Arch. Franç., 37, 1477) ; - Publication in expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46187
    Study title: Nouveaux regards sur l'hypertension artérielle de l'enfant - Broyer M., André J.L. - 1980 (Arch. Franç. Pediatr., 37, pp. 429-432) ; - Publication in expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46188
    Study title: Propanolol as an antihypertensive agent in children - Griswold W.R., Moneal R., Mendoza S.A. et al. - 1978 (Arch. Dis. Child. 537. pp 594-596) - Publication in Expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46189
    Study title: Relazione sulla sperimentazione clinica del Sectral Roger Bellon nelle aritmie - Centro A De Gasperis Milano - Prof F Rovelli - 03 Jan 1978
    Active substance: ACEBUTOLOL
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    Document reference: 46190
    Study title: Report of the task force on blood pressure control in children - Blumenthal S., Epps R.P., Heavenrich R., Laver R.M., Lieberman E. and al. - 1977 (Pediatrics, suppl., 59, 797) ; - Publication in expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46191
    Study title: Résultats du traitement de l'hypertension artérielle essentielle après administration prolongée (24 mois) d'acebutolol - Fillastre J.P., Letac B., Wolf L.M.- 1975 (Nouv. Presse Med. 4, pp. 3282-3286) ; - Publication in expertise clinique pour le dossier français de demande d'extension des indications thérapeutiques de Sectral 200 mg comprimés, au traitement de l'hypertension artérielle de l'enfant - Pr Broyer - 14/06/1983 -
    Active substance: ACEBUTOLOL
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    Document reference: 46192
    Study title: Spectral enfant – solution buvable à 40mg/ml – renseignements particuliers – partie V - No author - 01/10/1987
    Active substance: ACEBUTOLOL
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    Document reference: 46193
    Study title: Tolérance de 5 jours par voie orale chez le raton et le rat adulte suivie d’une période sans traitement de 15 jours (documentation toxicologique du dossier d’AMM du 30/10/87 du spectral enfant solution buvable 40mg/ml) - Briffaux - 02/10/1987
    Active substance: ACEBUTOLOL
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    Document reference: 46194
    Study title: Utilisation de l'acébutolol dans le traitement de l'hypertension artérielle de l'enfant et de l'adolescent - Andre J.L. & Spyckerelle - 1982 (Gazette médicale de France 89, n° 20, p. 2452-2454) ; - Publication in Documentation clinique du dossier d'AMM du 30/10/1987 -
    Active substance: ACEBUTOLOL
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    Document reference: 46195
    Study title: Usefulness of adenosine for arrythmias in infants and children - Overholt ED, Rheuban KS, Gutgesell HP - 1988 (Am. J. Cardiol., 61 : 336-340)Usefulness of adenosine for arrythmias in infants and children - Overholt ED, Rheuban KS, Gutgesell HP - 1988 (Am. J. Cardiol., 61 : 336-340)
    Active substance: ADENOSINE
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    Document reference: 46304
    Study title: Ventricular fibrillation following adenosine therapy for supraventricular tachycardia in a neonate with concealed Wolff-Parkinson-White syndrome treadted with digoxin - Mulla N et al. - 1995 (Pediatr. Emerg. Care, 11 (4) 238-239)Ventricular fibrillation following adenosine therapy for supraventricular tachycardia in a neonate with concealed Wolff-Parkinson-White syndrome treadted with digoxin - Mulla N et al. - 1995 (Pediatr. Emerg. Care, 11 (4) 238-239)
    Active substance: ADENOSINE
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    Document reference: 46305
    Study title: Adenosine and pediatric supraventricular tachycardiain the emergency department: a multi center study and review - Losek JD et al. - 02/1989 (Annals of emergency medicine, 33, 185-191)Adenosine and pediatric supraventricular tachycardiain the emergency department: a multi center study and review - Losek JD et al. - 02/1989 (Annals of emergency medicine, 33, 185-191)
    Active substance: ADENOSINE
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    Document reference: 46295
    Study title: Adenosine and pediatric supraventricular tachycardiain the emergency department: a multi center study and review - Losek JD et al. - 02/1989 (Annals of emergency medicine, 33, 185-191)Adenosine and pediatric supraventricular tachycardiain the emergency department: a multi center study and review - Losek JD et al. - 02/1989 (Annals of emergency medicine, 33, 185-191)
    Active substance: ADENOSINE
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    Document reference: 46306
    Study title: Adenosine induced atrial proarrhythmia in children - Jaeggi E et al. - February 1999 (Can J Cardiol, vol15, No2 , p169-172)Adenosine induced atrial proarrhythmia in children - Jaeggi E et al. - February 1999 (Can J Cardiol, vol15, No2 , p169-172)
    Active substance: ADENOSINE
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    Document reference: 46296
    Study title: Adenosine or adenosine triphosphate for supraventricular tachycardias ? Comparartive double blind randomized study in patients with spontaneous or inducible arrhytmias - Rankin AC, Olroyd KG, Chong E. - 1990 (Am. Heart J., 119: 316-323)Adenosine or adenosine triphosphate for supraventricular tachycardias ? Comparartive double blind randomized study in patients with spontaneous or inducible arrhytmias - Rankin AC, Olroyd KG, Chong E. - 1990 (Am. Heart J., 119: 316-323)
    Active substance: ADENOSINE
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    Document reference: 46297
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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