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Clinical trials for Enamel

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44380   clinical trials with a EudraCT protocol, of which   7392   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    Query did not match any clinical trials.
    These are paediatric studies completed by 26 January 2007, in respect of products authorised in the Community (Article 45 of the Paediatric Regulation (EC) No 1901/2006).
    Note: Advanced search filters for country, trial phase, gender, rare disease, IMP with orphan designation in the indication and age ranges of in-utero, adult or elderly do not apply to these records.
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    Study title: Open study to compare the caries reducing effect of a chlorhexidine varnish or a flouride varnish topically applied every 3rd month on the incidence of approximal caries in teenagers with a proven susceptibility to interdental enamel caries during a 3-year period.Petersson et al. (Caries Res 2000;34:140-143)
    Active substance: CALCIUM FLUORIDE AND SODIUM FLUORIDE
    Study summary document link (including results): EUdraCT_reduced datafields for Interim publication VOCO GmbH_Sodium flouride, Calcium flouride_2.xls
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    Document reference: 48185
    Study title: De Liefde B, Herbison GP. Prevalence of developmental defects of enamel and denatl caries in New Zealand children receiving differing fluoride supplementation. Community Dent Oral Epidemiol 1985; 13: 164-167
    Active substance: COLECALCIFEROL AND SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 24628
    Study title: Enamel opacities in the incisors of school children in a community in the canton of ZurichSteiner 1984
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): Steiner 1984 Enamel opacities in the incisors of school children.pdf
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    Document reference: 49180
    Study title: Fluoride level in surface enamelHotz 1987
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): Hotz 1987 Fluoride level in surface enamel.pdf
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    Document reference: 49168
    Study title: Fluorine concentration in primary tooth enamel in 6 year olds after 3 years of daily intake of fluoride-containing tablets.J. Widenheim, Lars G Petersson, Goran Koch 1984, Swed Dent J
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): 1984-widenheim-Fluoide concentration in primary tooth enamel in 6 years oldy after 3 years of daily intake of fluoridecontaining tablets.pdf
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    Document reference: 48777
    Study title: High-fluoride toothpaste and no post-brushing water rinsing on enamel demineralization using an in-sit caries model with orthodontic bands2010-AlMulla
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): 2010-AlMulla-high-fluoride toothpaste and no post-brushing water rinsing on enamel demineralization using an in-sit caries model with orthodontic b...
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    Document reference: 49098
    Study title: Fluorine concentration in primary tooth enamel in 6 year old after 3 years of daily intake1984-Widenheim
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): 1984-Widenheim-Fluorine concentration in primary tooth enamel in 6 year old after 3 years of daily intake.pdf
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    Document reference: 49155
    Study title: Enamel changes and dental caries in 7 years old children given fluoride tablets from shortly after birthA. Thylstrup, O. Fejerskov, C. Brunn, J. Kann 1979. Brit Dent.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): 1979-thylstrup-Enamel Changes and Dental Caries in 7-Year-Old children fiven fluoride tablets from shortly after birth.pdf
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    Document reference: 48779
    Study title: Caries rate, enamel fluoride concentration after fortnightly brushing with aminfluoride gelRan 1987
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results): Ran 1987 Caries rate, enamel fluoride concentration.pdf
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    Document reference: 49175
    Study title: In vitro fluoride uptake, distribution and retention by human enamel after 1- and 24-hour application of various topical fluoride agents.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42404
    Study title: In vitro fluoride uptake, distribution and retention by human enamel after 1- and 24-hour application of various topical fluoride agents.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42517
    Study title: Influence of F--releasing varnishes on the acid resistance of enamel.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42337
    Study title: Fluoride content of enamel during treatment and 2 years after discontinuation of treatment with fluoride varnishes.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42415
    Study title: Fluoride content of enamel during treatment and 2 years after discontinuation of treatment with fluoride varnishes.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42528
    Study title: Fluoride deposited topical applications in enamel. KOH-soluble and acquired fluoride.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42355
    Study title: Influence of F--releasing varnishes on the acid resistance of enamel.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42450
    Study title: Kinetics of fluorine in deciduous enamel after application of fluoride-containing varnish (Duraphat).
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42375
    Study title: Kinetics of fluorine in deciduous enamel after application of fluoride-containing varnish (Duraphat).
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42488
    Study title: Fluoride deposited topical applications in enamel. KOH-soluble and acquired fluoride.
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42468
    Study title: Fluoride retention in sound and demineralized enamel in vivo after treatment with a fluoride varnish (Duraphat).
    Active substance: SODIUM FLUORIDE
    Study summary document link (including results):
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    Document reference: 42390
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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