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Clinical trials for Musculoskeletal diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    1,431 result(s) found for: Musculoskeletal diseases. Displaying page 6 of 72.
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    EudraCT Number: 2013-000966-12 Sponsor Protocol Number: 12/0419 Start Date*: 2016-08-20
    Sponsor Name:University College London
    Full Title: Autologous Stem Cells in Achilles Tendinopathy (ASCAT)- A phase II, single centre, proof of concept study
    Medical condition: The Achilles tendon is the largest tendon in the body and it plays an important role in the biomechanics of the lower extremity.The disease to be studied in the trial is Achilles tendinopathy (AT)....
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004863 10000435 Achilles tendon injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-005982-18 Sponsor Protocol Number: COQ10-FM-2012 Start Date*: 2013-01-09
    Sponsor Name:Mónica Saldaña Valderas
    Full Title: Randomized, placebo-controlled and double blind clinical trial to assess the efficacy of ubidecarenone in patients diagnosed with fibromyalgia
    Medical condition: Fibromyalgia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10048439 Fibromyalgia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-003412-37 Sponsor Protocol Number: 323/12 Start Date*: 2015-08-10
    Sponsor Name:Keele University
    Full Title: Improving outcomes for patients with hip osteoarthritis: a randomised controlled trial
    Medical condition: Hip osteoarthritis
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-000541-20 Sponsor Protocol Number: STH15714 Start Date*: 2011-09-20
    Sponsor Name:Sheffield Teaching Hospitals NHS Foundation Trust
    Full Title: Effect of Denosumab on Osteolytic Lesion Activity in Total Hip Arthroplasty (THA)
    Medical condition: Prosthesis-related osteolysis after total hip arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2011-006152-36 Sponsor Protocol Number: 1774 Start Date*: 2012-05-10
    Sponsor Name:Middelfart Rygsektor
    Full Title: Postoperative treatment with parathyroidea hormone Forteo® in patients undergoing posterolateral spinal fusion surgery. A prospektive and a randomized double-blinded, placebo-controlled study
    Medical condition: Spinal stenosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10041597 Spinal stenosis of lumbar region LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-002611-96 Sponsor Protocol Number: ANAK/IL-01 Start Date*: 2014-02-12
    Sponsor Name:Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR)
    Full Title: Pilot study to determine the efficacy of anakinra (antagonist of interleukin-1 receptor) administered for 3 months in improving inflammatory signs observed by MRI in patients with erosive/inflammat...
    Medical condition: Patients with erosive/inflammatory hand osteoarthritis.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003770-32 Sponsor Protocol Number: CLR_14_05 Start Date*: 2016-01-04
    Sponsor Name:Sun Pharma Advanced Research Company
    Full Title: A Randomized, Double-Blind, Four Treatment, Four period, Crossover Study, with Placebo, Tizanidine Immediate Release and Diphenhydramine to Study the Effect of Tizanidine Extended Release on Simula...
    Medical condition: healthy volunteers (acute musculoskeletal pain)
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2018-000575-32 Sponsor Protocol Number: 1 Start Date*: 2018-12-18
    Sponsor Name:Isabel Maria Ruiz
    Full Title: Results of the injection of botulinum toxin vs platelet rich plasma for the treatment of plantar fasciitis
    Medical condition: Plantar fasciitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10035155 Plantar fasciitis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-004017-17 Sponsor Protocol Number: RR11/9965 Start Date*: 2013-04-08
    Sponsor Name:The University of Leeds
    Full Title: Prospective, Single-centre, Open-Label, Randomised, Pilot Study Assessing the changes in expression of JAK-STAT and Speed & Depth of Remission Induced by Tocilizumab & Methotrexate Combination and ...
    Medical condition: Rheumatoid Arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-003455-61 Sponsor Protocol Number: 2013GR06 Start Date*: 2015-02-11
    Sponsor Name:Tayside Academic Sciences Centre
    Full Title: Perindopril and Leucine to improve muscle function in older people
    Medical condition: Sarcopenia
    Disease: Version SOC Term Classification Code Term Level
    17.1 10028395 - Musculoskeletal and connective tissue disorders 10063024 Sarcopenia PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-006270-13 Sponsor Protocol Number: XCEL-MEN-01 Start Date*: 2013-01-08
    Sponsor Name:Banc de Sang i Teixits
    Full Title: A phase I-IIa safety and efficacy pilot clinical trial of intraarticular administration of autologous mesenchymal stem cells in meniscus injury
    Medical condition: Degenerative meniscal lesion
    Disease: Version SOC Term Classification Code Term Level
    15.0 10028395 - Musculoskeletal and connective tissue disorders 10069364 Meniscal degeneration PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-004087-30 Sponsor Protocol Number: 1007612/30.04.2010 Start Date*: 2011-08-25
    Sponsor Name:Tartu University Department of Sports Medicine and Rehabilitation
    Full Title: Effect of 12 weeks rehabilitation (aspect of neuromuscular physical therapy) in middle-aged patients in post-atroscopic period
    Medical condition: Cartilage Lesion of the Knee Joint
    Disease: Version SOC Term Classification Code Term Level
    14.0 10028395 - Musculoskeletal and connective tissue disorders 10023476 Knee osteoarthritis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: View results
    EudraCT Number: 2013-005025-23 Sponsor Protocol Number: XCEL-PSART-01 Start Date*: 2014-03-11
    Sponsor Name:Banc de Sang i Teixits (BST)
    Full Title: A phase IIa, unicenter, prospective, randomized, parallel, two-arms, single-dose, open-label with blinded assessor pilot clinical trial to assess ex vivo expanded adult autologous mesenchymal strom...
    Medical condition: pseudarthrosis
    Disease: Version SOC Term Classification Code Term Level
    16.1 10028395 - Musculoskeletal and connective tissue disorders 10048617 Pseudarthrosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2017-002798-21 Sponsor Protocol Number: 13337 Start Date*: 2018-06-19
    Sponsor Name:University of Oxford
    Full Title: A multi-centre, blinded, randomised, placebo-controlled trial assessing the clinical and cost effectiveness of a 12 month course of oral alendronate (70mg weekly) in patients presenting with avascu...
    Medical condition: Early stage (Ficat 1 or 2), symptomatic, Avascular Necrosis (AVN) of the femoral head
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10005959 Bone disorders (excl congenital and fractures) HLGT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2017-003425-15 Sponsor Protocol Number: 2017 Start Date*: 2017-11-10
    Sponsor Name:Videncenter for Reumatologi og Rygsygdomme, Rigshospitalet
    Full Title: Patients with rheumatoid arthritis and synovitis treated with ultrasound guided intraarticular or intramuscular glucocorticoid injection - A randomised, double-blind, controlled study (Panguian)
    Medical condition: Treatment of synovitis among rheumatoid arthritis patients
    Disease: Version SOC Term Classification Code Term Level
    21.0 10028395 - Musculoskeletal and connective tissue disorders 10042868 Synovitis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-004054-41 Sponsor Protocol Number: KCE-16002 Start Date*: 2018-05-07
    Sponsor Name:University Hospitals Leuven
    Full Title: CareRA2020: Effectiveness of a combination of Methotrexate and a step down glucocorticoid regimen (COBRA-Slim) for remission induction in patients with early Rheumatoid Arthritis (RA), with or with...
    Medical condition: early active Rheumatoid Arthritis, previously untreated with DMARDs
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10039073 Rheumatoid arthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: View results
    EudraCT Number: 2016-001906-41 Sponsor Protocol Number: MRHT_ES-IF_RCT001 Start Date*: 2016-08-08
    Sponsor Name:Royal College of Surgeons in Ireland
    Full Title: A randomised control trial of intra articular injectates in knee osteoarthritis: A comparison of corticosteroid (Methylprednisolone Acetate) and NSAID (Ketorolac tromethamine) injections
    Medical condition: Knee osteoarthritis is the condition of interest. Osteoarthritis is a common musculoskeletal complaint, with an underlying pathogenesis related to bio-mechanical stress loading, resulting in initia...
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-003932-35 Sponsor Protocol Number: BIO101-CL03 Start Date*: 2018-02-20
    Sponsor Name:Biophytis S.A.
    Full Title: Safety and Efficacy of BIO-101 175 mg b.i.d. and 350 mg b.i.d. 26-week oral administration to patients suffering from age-related SARcopenia, including sarcopenic obesity, Aged ≥65 years and at ris...
    Medical condition: Sarcopenia including sarcopenic obesity
    Disease: Version SOC Term Classification Code Term Level
    20.1 10028395 - Musculoskeletal and connective tissue disorders 10063024 Sarcopenia PT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-000930-37 Sponsor Protocol Number: STEMQUIRI/12ES01 Start Date*: 2014-04-29
    Sponsor Name:Laboratorios Salvat, S.A.
    Full Title: A phase II clinical trial to assess the effect of HC-SVT-1001 (autologous fat stem adult mesenchymal cells expanded and combined with a tricalcium phosphate biomaterial) and HC-SVT-1002 (allogeneic...
    Medical condition: Atrophic pseudarthrosis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10028395 - Musculoskeletal and connective tissue disorders 10048617 Pseudarthrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-001068-27 Sponsor Protocol Number: 2020-001068-27 Start Date*: 2020-12-01
    Sponsor Name:Leiden University Medical Center
    Full Title: Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial
    Medical condition: Chronic nonbacterial osteitis (CNO) in adults
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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