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Clinical trials for Botulinum

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    276 result(s) found for: Botulinum. Displaying page 1 of 14.
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    EudraCT Number: 2016-001378-13 Sponsor Protocol Number: 001 Start Date*: 2017-02-02
    Sponsor Name:University Hospital Wuerzburg
    Full Title: A randomized, sham-controlled trial of pallidal neurostimulation versus botulinum toxine treatment for cervical dystonia.
    Medical condition: cervical dystonia
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004859 10064124 Cervical dystonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-000096-36 Sponsor Protocol Number: Botox-01 Start Date*: 2021-06-23
    Sponsor Name:Department of Dermatology and Copenhagen Wound Healing Center, Bispebjerg Hospital
    Full Title: The effect of subcutaneous injection of Botulinum Toxin A on chronic wound pain in lower extremities, a prospective exploratory study
    Medical condition: chronic wound pain and wound healing
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10049542 Wound pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2017-001216-11 Sponsor Protocol Number: FISAN-BOT-2017-01 Start Date*: 2017-04-25
    Sponsor Name:Dra. A. Teresa Calderón Duque
    Full Title: Usefulness of botulinum toxin type A in the treatment of chronic anal fissure
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-018226-29 Sponsor Protocol Number: botox2010 Start Date*: 2010-04-20
    Sponsor Name:
    Full Title: The effect of botulinum toxin type A injections in the m. rectus femoris in stroke patients presenting with a stiff knee gait.
    Medical condition: Stroke patients with stiff knee gait. Stiff knee gait is characterized as a diminished knee flexion during swing phase of gait. It is common in stroke patients.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-002176-25 Sponsor Protocol Number: 1510150 Start Date*: 2016-04-01
    Sponsor Name:Royal Devon and Exeter NHS Foundation Trust
    Full Title: Do ultrasound guided botulinum A injections relieve pain in rotator cuff arthropathy?
    Medical condition: Rotator Cuff Tear Arthropathy
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000740-34 Sponsor Protocol Number: EPITBA12 Start Date*: 2017-09-28
    Sponsor Name:Dr. Borja Maroto Rodríguez
    Full Title: Treatment of functional EPIFORA with Botulinum Toxin versus lateral tarsal strip
    Medical condition: Functional Epifora
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2011-003132-30 Sponsor Protocol Number: BTXHH11 Start Date*: 2011-09-09
    Sponsor Name:Svettmottagningen Hidroskliniken, Stockholm
    Full Title: Botulinum toxin treatment in craniofacial, inguinal, palmar, plantar and truncal hyperhidrosis, a randomized, double blind, placebo controlled study.
    Medical condition: Hyperhidrosis-craniofacial, inguinal, palmar, plantar and truncal.
    Disease: Version SOC Term Classification Code Term Level
    17.1 10040785 - Skin and subcutaneous tissue disorders 10020642 Hyperhidrosis PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002812-24 Sponsor Protocol Number: Start Date*: 2007-10-15
    Sponsor Name:AKH Wien, Universitätsklinik für Physikalische Medizin und Rehabilitation
    Full Title: Behandlung mit Botulinum Toxin A bei Kindern mit Morbus Perthes (Treatment with Botulinum Toxin A in Infants with Perthes Disease)
    Medical condition: therapy-resistent reduction of range of motion in infants with perthes disease
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-003503-35 Sponsor Protocol Number: PAINTX Start Date*: 2020-02-03
    Sponsor Name:Region Östergötland
    Full Title: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of the Effect of Botulinum Toxin A on Patients with Atypical Odontalgia/Persistent Dentoalveolar Pain.
    Medical condition: Atypical Odontalgia/Persistent Dentoalveolar Pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000095-10 Sponsor Protocol Number: BATCP Start Date*: 2015-03-30
    Sponsor Name:Karolinska Institutet
    Full Title: Botulinum toxin-A as a treatment for chronic muscle-related pain in adults with spastic cerebral palsy: a randomized controlled trial.
    Medical condition: Spastic cerebral palsy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-005723-20 Sponsor Protocol Number: RC31/20/0445 Start Date*: 2022-02-10
    Sponsor Name:CHU de Toulouse
    Full Title: Evaluation of Botulinum TOXin type A in the treatment of Buerger’s disease
    Medical condition: This study assesses the feasibility and safety of treatment with botulinum toxin injection in patients with Buerger's disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2022-004127-40 Sponsor Protocol Number: ESPSEVMOLIN2022 Start Date*: 2023-05-03
    Sponsor Name:Dra. Nuria Gutierrez Dubón
    Full Title: Clinical trial on the effectiveness and safety of botulinum toxin type A (incobotulinumtoxin) in doses adapted to the individual needs of patients with severe spasticity
    Medical condition: brain damage oriented spasticity
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-005547-23 Sponsor Protocol Number: 12217 Start Date*: 2021-07-22
    Sponsor Name:AZ Delta vzw
    Full Title: Management of Popeye sign with botulinum toxin after tenotomy of the long head of the biceps tendon: a double-blinded randomized controlled trial
    Medical condition: Popeye sign or cramping pain after shoulder artroscopy with biceps tenotomy
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-000129-76 Sponsor Protocol Number: BTXSENS Start Date*: 2007-04-27
    Sponsor Name:Guy's & St Thomas' NHS Foundation Trust
    Full Title: Botulinum toxin-A in Sensory Urgency
    Medical condition: Sensory Urinary Urgency. This is a condition where patients have urinary urgency (sudden desire to urinate which cannot be deferred) /- urge incontinence (urine leakage) and usually is accompanied ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10059617 Overactive bladder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-010338-23 Sponsor Protocol Number: RD.03.SPR.29081 Start Date*: 2009-06-09
    Sponsor Name:GALDERMA Research & Development
    Full Title: Intra-individual randomized comparison of the efficacy of two botulinum toxins type A on moderate to severe forehead wrinkles after one injection
    Medical condition: Moderate to severe forehead wrinkles
    Disease: Version SOC Term Classification Code Term Level
    9.1 10040954 Skin wrinkling LLT
    Population Age: Adults Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-005068-82 Sponsor Protocol Number: OZR-2012-07 Start Date*: 2013-04-08
    Sponsor Name:The Rotterdam Eye Hospital
    Full Title: An alternative approach for treatment of infantile esotropia with botulinum toxin A.
    Medical condition: infantile esotropia
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-006169-15 Sponsor Protocol Number: ALLCD001 Start Date*: 2006-05-18
    Sponsor Name:Allergan Limited
    Full Title: A Double-Blind, Randomised, Cross-over, Safety and Efficacy Pilot Study Comparing Two Botulinum Toxin Type-A Products in the Treatment of Moderate to Severe Cervical Dystonia.
    Medical condition: Cervical dystonia is the most common form of focal dystonia prevalent at a rate of 89 per million individuals. Sustained involuntary contractions of the neck muscles, lead to painful and disabling ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-006170-10 Sponsor Protocol Number: ALLBL001 Start Date*: 2006-06-22
    Sponsor Name:Allergan Limited
    Full Title: A Double-Blind, Randomised, Parallel group, Safety and Efficacy Pilot Study Comparing Two Botulinum Toxin Type-A Products in the Treatment of Blepharospasm
    Medical condition: Blepharospasm is a focal dystonia characterised by excessive involuntary contraction of the orbicularis oculi muscles. In severe cases, tonic eyelid closure can lead to functional blindness and can...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-004795-19 Sponsor Protocol Number: 120824001 Start Date*: 2013-03-12
    Sponsor Name:Folktandvården Västra Götaland
    Full Title: Utilisation of botulinum toxin type A on masticatory muscel hyperactivity in CP - a randomized, controlled study.
    Medical condition: Masticatory muscle hyperactivity/bruxism in patients with Cerebral Palsy.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10028037 Movement disorders (incl parkinsonism) HLGT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2021-002819-60 Sponsor Protocol Number: FAC-BOTOX Start Date*: 2021-08-19
    Sponsor Name:Hospital Universitario de Burgos
    Full Title: Treatment of chronic anal fissure with ultrasound-guided intersphincteric infiltration of botulinum toxin A.
    Medical condition: Chronic anal fissure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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