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Clinical trials for Calcineurin inhibitor

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    74 result(s) found for: Calcineurin inhibitor. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2017-000177-37 Sponsor Protocol Number: LITE Start Date*: 2017-09-21
    Sponsor Name:King's College London [...]
    1. King's College London
    2. King's College Hospital
    Full Title: Low-dose IL-2 to expand endogenous regulatory T cells and achieve tolerance in liver transplantation
    Medical condition: Discontinuation of immunosuppression in liver transplantation
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10024714 Liver transplant PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-018377-38 Sponsor Protocol Number: MICH Start Date*: 2010-03-12
    Sponsor Name:Leiden University Medical Centre
    Full Title: Immune respons after inactivated oral cholera vaccin (Dukoral) in renal transplant recipients Mucosal response in ImmunoCompromised Host (MICH)
    Medical condition: Single centre, interventional, non-parallel-group trial. Aim: To assess the immunogenicity of inactivated oral cholera vaccine (Dukoral) in renal transplant recipients and healthy controls.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000624-28 Sponsor Protocol Number: OFA2 Start Date*: Information not available in EudraCT
    Sponsor Name:IRCCS ISTITUTO GIANNINA GASLINI
    Full Title: Ofatumumab versus Rituximab in children with steroid and calcineurin inhibitor-dependent idiopatic nephrotic syndrome: an open-label, randomized, controlled, superiority trial.
    Medical condition: steroid and calcineurin inhibitor-dependent idiopatic nephrotic syndrome
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038359 - Renal and urinary disorders 10029164 Nephrotic syndrome PT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005925-12 Sponsor Protocol Number: polyoma IFB 29 Start Date*: 2011-01-20
    Sponsor Name:Medizinische Hochschule Hannover
    Full Title: Polyomavirus BK nephropathy after renal transplantation: Randomized clinical trial to demonstrate that switching to mTOR inhibitor is more effective than a reduction of immunosuppressive therapy
    Medical condition: Polyoma BK-virus nephropathy is a viral complication after renal transplantation attacking up to 10% of renal transplants and causing transplant failure in 45% of cases. No virustatic treatment exi...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-004607-11 Sponsor Protocol Number: Start Date*: 2006-02-23
    Sponsor Name:Hopital Erasme
    Full Title: Prospective, randomized, long-term study compairing a Neoral (C-0h monitoring)-based steroid-free to an everolimus-myfortic based, calcineurin-inhibitor-free immunosuppressive treatment on graft fu...
    Medical condition: “De novo” renal transplantation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-007177-20 Sponsor Protocol Number: Sirolimus_Liver_Tolerance Start Date*: 2009-09-07
    Sponsor Name:Hospital Clinic Barcelona
    Full Title: EFECTO DEL SIROLIMUS SOBRE LOS BIOMARCADORES RELACIONADOS CON LA TOLERANCIA EN RECEPTORES DE TRASPLANTE HEPÁTICO ESTABLES
    Medical condition: Stable liver transplant recipients identified as non-tolerant (i.e. requiring indefinite immunosuppressive therapy) on the basis of peripheral blood transcriptional biomarkers.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024716 Liver transplantation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-000605-12 Sponsor Protocol Number: notapplicable1 Start Date*: 2014-06-13
    Sponsor Name:
    Full Title: Thiazide diuretics versus calcium channel blockers for the treatment of calcineurin inhibitor-induced hypertension in patients with psoriasis or eczema: a single-center randomized cross-over trial.
    Medical condition: Hypertension, induced by the use of a Calcineurin Inhibitor (CNI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-014436-38 Sponsor Protocol Number: 2009/07 Start Date*: 2009-09-25
    Sponsor Name:UMCG
    Full Title: A prospective, open, randomized, single center study comparing the effects of duo therapy with Everolimus and steroids versus triple treatment of low dose calcineurin inhibitor, low-dose MMF and st...
    Medical condition: Renal transplantation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002102-22 Sponsor Protocol Number: CeCaRi Start Date*: 2007-10-10
    Sponsor Name:Gasthuisberg Leuven
    Full Title: Multicenter, prospective, randomized, open-label study of the safety and efficacy of a Certican® -based regimen versus a calcineurin inhibitor (CNI)-based regimen in maintenance heart transplant re...
    Medical condition: This study is designed to evaluate whether Certican® initiation, together with discontinuation of calcineurin inhibitors (CNIs) will have a beneficial effect on the renal function in maintenance he...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-022075-66 Sponsor Protocol Number: 10/CMC/4767E Start Date*: 2010-12-16
    Sponsor Name:Cardif and Vale University Local Health Board
    Full Title: A Single Centre Physiological Study of Glucose Metabolism Before and After Tacrolimus Withdrawal For Deteriorating Kidney Function In Renal Transplant Recipients
    Medical condition: Alterations in glucose metabolism secondary to tacrolimus (Prograf), a calcineurin inhibitor, after kidney transplantation.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-000322-66 Sponsor Protocol Number: CRAD001A2433 Start Date*: 2013-11-07
    Sponsor Name:Novartis Pharma Services AG
    Full Title: A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibi...
    Medical condition: Adult kidney transplant recipients.
    Disease: Version SOC Term Classification Code Term Level
    19.0 10038359 - Renal and urinary disorders 10064848 Chronic kidney disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IT (Completed) SK (Completed) ES (Completed) PT (Completed) AT (Completed) NL (Completed) BE (Completed) GR (Completed) CZ (Completed) SI (Completed) BG (Completed) PL (Completed) HR (Completed) NO (Completed) SE (Completed) FR (Completed)
    Trial results: View results
    EudraCT Number: 2018-000237-12 Sponsor Protocol Number: IM103-402 Start Date*: 2021-05-04
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Prospective, Open-label, Multicenter, Randomized Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Renal Allograft Recipients Aged 12 to Less Than 18 Years of Age to a...
    Medical condition: Adolescent Renal Allografts
    Disease: Version SOC Term Classification Code Term Level
    21.0 10042613 - Surgical and medical procedures 10038533 Renal transplant PT
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DE (Trial now transitioned) FR (Trial now transitioned) NL (Trial now transitioned) BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-001043-39 Sponsor Protocol Number: ML17225 Start Date*: 2016-10-03
    Sponsor Name:F. Hoffmann-La Roche AG
    Full Title: An Open-Label, Prospective, Randomized, Controlled, Multi-Center Study Assessing Fixed Dose Vs Concentration Controlled Cellcept Regimens For Patients Following A Single Organ Renal Transplantation...
    Medical condition: Renal Transplantation
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10023438 Kidney transplant LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2006-002420-41 Sponsor Protocol Number: 0468E7-408 Start Date*: 2006-09-27
    Sponsor Name:Wyeth Research, Division of Wyeth Pharmaceuticals, Inc.
    Full Title: A Randomized, Open-Label Study to Compare the Safety and Efficacy of Conversion From a Calcineurin Inhibitor to Sirolimus Versus Continued Use of a Calcineurin Inhibitor in Cardiac Transplant Recip...
    Medical condition: Cardiac transplant recipients with mild to moderate renal insufficiency.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050432 Prophylaxis against heart transplant rejection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) CZ (Completed) ES (Completed)
    Trial results: View results
    EudraCT Number: 2006-005687-44 Sponsor Protocol Number: 0468H1-316 Start Date*: 2015-04-10
    Sponsor Name:Wyeth Research
    Full Title: A Randomized, Open-Label, Comparative Evaluation of Conversion From Calcineurin Inhibitors to Sirolimus Versus Continued Use of Calcineurin Inhibitors in Renal Allograft Recipients
    Medical condition: Renal Transplantation
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2007-002763-27 Sponsor Protocol Number: PRINS study Start Date*: 2007-09-12
    Sponsor Name:Erasmus MC
    Full Title: A multi-center, randomized, controlled trial with programmed introduction of Sirolimus-based, Calcineurin inhibitor free immunosuppression in recipients of non-heart-beating donor kidney grafts.
    Medical condition: Recipients of a renal allograft from a non-heart-beating donor, three months after transplantation.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023438 Kidney transplant LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-002243-98 Sponsor Protocol Number: 29702 Start Date*: 2011-09-12
    Sponsor Name:Department of Nephrology, OUH, Odense, DK
    Full Title: The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity
    Medical condition: Kidney graft failure
    Disease: Version SOC Term Classification Code Term Level
    18.0 10022117 - Injury, poisoning and procedural complications 10010185 Complications of transplanted kidney PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2015-000569-30 Sponsor Protocol Number: OFA1 Start Date*: 2015-06-16
    Sponsor Name:IRCCS ISTITUTO GIANNINA GASLINI
    Full Title: Ofatumumab in children with steroid- and calcineurin-inhibitor-resistant nephrotic syndrome: a double-blind randomized, controlled, superiority trial
    Medical condition: Steroid- and calcineurin-inhibitor-resistant nephrotic syndrome
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004857 10072914 Steroid-resistant nephrotic syndrome LLT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004884-31 Sponsor Protocol Number: Nuth-2005-3400 Start Date*: 2008-01-10
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Trust
    Full Title: An open label, randomized pilot study evaluating the early conversion from calcineurin inhibitors to Rapamune in patients with impaired renal function following kidney transplantation
    Medical condition: This study will be conducted in 60 established renal allograft recipients who have suffered from chronic renal failure of any cause.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-012194-35 Sponsor Protocol Number: 290404BS Start Date*: 2009-12-22
    Sponsor Name:bioskin GmbH
    Full Title: A single-center, randomized, controlled, observer-blind, phase IV study to develop the atopic localized eczema regression test (ALERT) using marketed topical corticosteroid formulations of differen...
    Medical condition: Patients with a pre-disposition for Atopic Dermatitis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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