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Clinical trials for ED50

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    14 result(s) found for: ED50. Displaying page 1 of 1.
    EudraCT Number: 2008-002335-32 Sponsor Protocol Number: AN08/8505 Start Date*: 2008-11-28
    Sponsor Name:The University of Leeds
    Full Title: Does concentration affect the ED50 of bupivacaine for supraclavicular brachial plxus block?
    Medical condition: Not applicable
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-004278-10 Sponsor Protocol Number: 2004/R/AN/04 Start Date*: 2005-02-10
    Sponsor Name:Lothian Health Board- University Hospitals Division [...]
    1. Lothian Health Board- University Hospitals Division
    2. Lothian Health Board University Hospitals Division
    Full Title: Determination of the subarachnoid ED50 and ED95 of hyperbaric 0.5% bupivacaine when co-administered with diamorphine hydrochloride for caesarean section
    Medical condition: patients undergoing elective caesarean section
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-000709-55 Sponsor Protocol Number: SugaRoc Start Date*: 2020-04-01
    Sponsor Name:Universitair Ziekenhuis Brussel
    Full Title: Sugammadex dose-finding study for reversal of deep rocuronium-induced neuromuscular block
    Medical condition: decurarisation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002946-11 Sponsor Protocol Number: 111852 Start Date*: 2015-05-22
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase IIIb, open label, randomized, multicenter study of the im-munogenicity and safety of a booster dose of Kinrix when co-administered with varicella vaccine (Varivax®, Merck and Company) and M...
    Medical condition: Booster immunization of healthy children 4-6 years of age against diphtheria, tetanus, pertussis and polio diseases.
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2015-002958-12 Sponsor Protocol Number: 2015-003-M Start Date*: 2015-09-15
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Median Local Anaesthetic dose (MLAD) of Intrathecal Bupivacaine in total hip arthroplasty with the anterior approach.
    Medical condition: Spinal anesthesia during total hip arthroplasty with anterior approach
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000082-23 Sponsor Protocol Number: 2016-001-M Start Date*: 2016-03-11
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Median Local Anaesthetic Dose (MLAD) of intrathecal Bupivacaine in total knee arthroplasty
    Medical condition: Spinal anaesthesia during total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002397-12 Sponsor Protocol Number: 2016-011-M Start Date*: 2016-08-11
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Median Local Anaesthetic dose (MLAD) of Intrathecal Prilocaïne in total hip arthroplasty with the anterior approach.
    Medical condition: Spinal anesthesia during total hip arthroplasty with anterior approach
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-004624-11 Sponsor Protocol Number: Jonto01 Start Date*: 2019-03-13
    Sponsor Name:Region Östergötland
    Full Title: A non-randomized experimental study to optically study pharmacodynamic responses in the delivery of vasoactive substances to the skin through iontophoresis in healthy volunteers
    Medical condition: Healthy volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-002136-15 Sponsor Protocol Number: 2008 AN02 Start Date*: 2010-01-25
    Sponsor Name:Ninewells Hospital and Medical School
    Full Title: A randomised single blind study comparing the molar ED50 of levobupivacaine and molar ED50 of ropivacaine when administered as a femoral perineural infusion for pain relief after total knee replace...
    Medical condition: Pain after total knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    9.1 10003398 Arthroplasty of knee LLT
    9.1 10036236 Postoperative pain relief LLT
    9.1 10024758 Local anaesthesia LLT
    9.1 10041536 Spinal anaesthesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2019-001534-34 Sponsor Protocol Number: 260319 Start Date*: 2022-03-11
    Sponsor Name:Odense University Hospital
    Full Title: Propofol and thiopental for intravenous induction in neonates: a dose finding study
    Medical condition: Any condition requiring general anesthesia.
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10018061 General anesthesia LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-002559-27 Sponsor Protocol Number: 2017-03 Start Date*: 2018-03-29
    Sponsor Name:Zaans Medisch Centrum
    Full Title: ED50 and ED90 of intrathecal 1% chloroprocaine in day-case knee arthroscopy
    Medical condition: Patients scheduled for ambulatory knee arthroscopy surgery receive intrathecal chloroprocaine
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-000464-34 Sponsor Protocol Number: AF219-015 Start Date*: 2015-04-29
    Sponsor Name:Afferent Pharmaceuticals, Inc.
    Full Title: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects
    Medical condition: Chronic Cough
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-005282-78 Sponsor Protocol Number: 114720 Start Date*: 2016-08-17
    Sponsor Name:GlaxoSmithKline Biologicals
    Full Title: A phase IV, randomised, open-label, controlled study to assess the immunogenicity and safety of the diphtheria, tetanus, pertussis and inactivated poliovirus (DPT-IPV) vaccine Squarekids™ when co-a...
    Medical condition: Active immunisation of infants against gastroenteritis (GE) due to rotavirus (RV).
    Disease: Version SOC Term Classification Code Term Level
    19.0 10021881 - Infections and infestations 10021881 Infections and infestations SOC
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2006-002696-40 Sponsor Protocol Number: ACH171-002 Start Date*: 2006-10-12
    Sponsor Name:Achillion Pharmaceuticals, Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of Multiple Doses of ACH-0137171 in Subjects w...
    Medical condition: Chronic Hepatitis C Infection
    Disease: Version SOC Term Classification Code Term Level
    8.1 10008912 Chronic hepatitis C LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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