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Clinical trials for Endothelium

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43873   clinical trials with a EudraCT protocol, of which   7293   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    71 result(s) found for: Endothelium. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2007-006233-14 Sponsor Protocol Number: 2007-006233-14 Start Date*: 2008-01-03
    Sponsor Name:Academic Medical Center
    Full Title: Organ protection by noble gases – Helium induced Early and Late Preconditioning (HELP) in human endothelium
    Medical condition: healthy volunteers helium induced organ protection
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-011723-31 Sponsor Protocol Number: VPA-study Start Date*: 2009-12-09
    Sponsor Name:Västra Götalandsregionen
    Full Title: Effects of valproic acid on fibrinolysis in man
    Medical condition: This is a healthy volunteer trial. The intended indication for the product is to investigate if upregulation of the tPA-gene by valproic acid results in increased tPA-release from endothelium in f...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10016603 Fibrinolysis LLT
    Population Age: Adults Gender: Male
    Trial protocol: SE (Restarted)
    Trial results: (No results available)
    EudraCT Number: 2006-004427-11 Sponsor Protocol Number: 060317 Start Date*: 2006-10-27
    Sponsor Name:Univ of Lund, Dept of Pediatrics
    Full Title: Effects of Omega-3-Fatty Acids on Arterial Endothelial Function and Intima Media Thickness in Children with Insulin-Dependent Diabetes Mellitus
    Medical condition: Diabetes mellitus type 1 in children
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-016053-18 Sponsor Protocol Number: VILD1 Start Date*: 2009-12-09
    Sponsor Name:UMC St Radboud
    Full Title: The effect of vildagliptin on endothelium-dependent vasodilatation. A double blind, cross-over study in type 2 diabetes.
    Medical condition: The effect of vildagliptin on endothelial dysfunction in type 2 diabetes, assessed by measuring endothelium-dependent vasodilatation
    Disease: Version SOC Term Classification Code Term Level
    12.0 10048554 Endothelial dysfunction LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2006-005227-42 Sponsor Protocol Number: PM1108357 Start Date*: 2007-08-30
    Sponsor Name:GlaxoSmithKline Research & Development Ltd
    Full Title: A double-blind, placebo-controlled, parallel study to evaluate the effects of GW-856553 on endothelial function/ vascular compliance in subjects with dyslipidaemia.
    Medical condition: GW-856553 is under development as a potential anti-atherosclerosis agent for reduction of major cardiovascular events in high risk patient populations
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-016600-23 Sponsor Protocol Number: 05102009 Start Date*: 2010-07-09
    Sponsor Name:Hull and East Yorkshire Hospitals NHS Trust
    Full Title: A double blind, randomised, placebo controlled trial to study the clinical effectiveness of Angiotensin Converting Enzyme (ACE) inhibitors, ramipril,in patients with intermittent claudication
    Medical condition: Intermittent Claudication
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-001733-86 Sponsor Protocol Number: 1710 Start Date*: 2014-10-15
    Sponsor Name:Maastricht University
    Full Title: The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects
    Medical condition: Obesity, glucose intolerance, endothelial dysfunction
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000783-42 Sponsor Protocol Number: SDX-PL/001/2016 Start Date*: 2016-09-19
    Sponsor Name:Alfa Wassermann Polska Sp. z o.o.
    Full Title: A phase 3, prospective, open, pilot, monocentric study to evaluate the effect of sulodexide administered at registered dose on morphology and functional properties of the venous endothelium in pati...
    Medical condition: chronic venous insufficiency
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004866 10066682 Chronic venous insufficiency LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-018369-48 Sponsor Protocol Number: CASTIP3 Start Date*: 2011-03-10
    Sponsor Name:Medizinische Universität Wien
    Full Title: Der Einfluss von Adalimumab auf kardiovaskuläre und metabolische Risikofaktoren in der Therapie von Patienten mit mittelschwerer bis schwerer Psoriasis vulgaris im Vergleich zu einer Standardtherap...
    Medical condition: Psoriasis vulgaris
    Disease: Version SOC Term Classification Code Term Level
    12.1 10050576 Psoriasis vulgaris LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2011-005666-37 Sponsor Protocol Number: PrefoDIP Start Date*: 2012-10-17
    Sponsor Name:ZAMBON ITALIA
    Full Title: Evaluation of the effect exerted by 5-methyltetrahydrofolate (5-MTHF) and folic acid in postmenopausal women
    Medical condition: The study evaluates the effects of different forms of folates on cardiovascular risk factors in postmenopausal patients
    Disease: Version SOC Term Classification Code Term Level
    14.1 10041244 - Social circumstances 10051775 Postmenopause PT
    Population Age: Adults Gender: Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-001688-74 Sponsor Protocol Number: WX18694 Start Date*: 2005-09-22
    Sponsor Name:Guy's & St Thomas' NHS Foundation Trust
    Full Title: A prospective, randomized, double-blind, placebo controlled trial evaluating the effects of Mycophenolate Mofetil (MMF) on 'surrogate markers' for atherosclerosis in female patients with systemic l...
    Medical condition: Atherosclerosis in patients with Systemic Lupus Erythematosis
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000173-39 Sponsor Protocol Number: Kin-Net-2013-33-Ger Start Date*: 2014-12-08
    Sponsor Name:Jan van Breemen Research Institute Reade and VU University Medical Centre
    Full Title: The effect of IL-1 inhibition by anakinra in acute gout - A proof of concept study-
    Medical condition: Gout
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004529-57 Sponsor Protocol Number: 06/AM/108 Start Date*: 2008-09-08
    Sponsor Name:Greenpark Healthcare Trust
    Full Title: Vascular Pleiotrophic Effects of Bisphosphonates in Post Menopausal Women with Osteoporosis: Cellular Mechanisms and Functional Consequences
    Medical condition: osteoporosis cardiovascular disease
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-017537-21 Sponsor Protocol Number: PHT/2009/36 Start Date*: 2010-03-02
    Sponsor Name:Portsmouth Hospitals NHS Trust
    Full Title: Oral thiamine (Vitamin B1) supplementation in subjects with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled crossover trial assessing biophysical markers of endothelial fun...
    Medical condition: Type 2 diabetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-000353-21 Sponsor Protocol Number: substance P Start Date*: 2006-05-29
    Sponsor Name:Cliniques Universitaire St Luc
    Full Title: Comparison of the vasoreactivity and endogenous NO production between the left and right internal mammary 6 months after bypass surgery with the injection of substance P and exogenous nitric oxide.
    Medical condition: We observe a higher FFR in the RITA then in the LIMA 6 month after CABG (Glineur D, Resistance to flow of arterial Y-grafts 6 months after coronary artery bypass surgery.Circulation. 2005 Aug 30;1...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-004641-42 Sponsor Protocol Number: 65371 Start Date*: 2007-04-23
    Sponsor Name:Gedeon Richter Plc
    Full Title: Single center, exploratoric, open-label study to investigate the precise mechanism of action of Cavinton (vinpocetin)
    Medical condition: endothel dysfunction and peripherial circulation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed)
    Trial results: View results
    EudraCT Number: 2019-000133-39 Sponsor Protocol Number: 2019-02-07 Start Date*: 2019-05-08
    Sponsor Name:Academic Medical Center
    Full Title: A proof-of-concept study to evaluate 99mTechnetium radiolabeled Fucoidan as a diagnostic modality for thrombosis
    Medical condition: Deep vein thrombosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-001561-28 Sponsor Protocol Number: HES08 Start Date*: 2008-07-21
    Sponsor Name:Klinik für Anästhesiologie und Operative Intensivmedizin Klinikum Ludwigshafen
    Full Title: Influence of perioperative HES 130/04 adminstration on postoperative complications: A prospective randomized trial in patients undergoing colorectal surgery.
    Medical condition: Adult patients (>18 years) of both gender undergoing elective colorectal surgery (hemicolectomy left/right, sigmoid colectomy, rectal resection/amputation) without concomitant resection of liver me...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-003215-35 Sponsor Protocol Number: PXL008-017 Start Date*: 2016-12-12
    Sponsor Name:Poxel
    Full Title: A phase 2a, randomised, double-blind, placebo-controlled, cross-over, single and multiple dose study to assess the effects of imeglimin on nicotine-induced endothelial dysfunction in young non-smok...
    Medical condition: Diabetes Mellitus, Type 2
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004861 10045242 Type II diabetes mellitus LLT
    Population Age: Adults Gender: Male
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-001794-28 Sponsor Protocol Number: 806 Start Date*: 2007-10-15
    Sponsor Name:OrbusNeich Medical BV
    Full Title: Endothelial Function following stenting with Genous vs Drug-Eluting Stents
    Medical condition: Patients with symptomatic ischemic heart disease expressing one or two de novo native coronary artery lesions
    Disease: Version SOC Term Classification Code Term Level
    9.1 10011078 Coronary artery disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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