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Clinical trials for Esophageal disease

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    336 result(s) found for: Esophageal disease. Displaying page 1 of 17.
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    EudraCT Number: 2009-013259-31 Sponsor Protocol Number: 6232 Start Date*: 2009-12-29
    Sponsor Name:UMC Utrecht
    Full Title: A multicenter double blind placebo-controlled randomised trial for benign esophageal anastomotic strictures: Savary dilation vs savary dilation with Triamcinolon
    Medical condition: Patients with first time dysphagia (grade 2-4) due to a benign anastomotic esophageal stricture
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015449 Esophageal stricture LLT
    9.1 10030199 Oesophageal stricture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018298-39 Sponsor Protocol Number: botox2010 Start Date*: 2010-02-15
    Sponsor Name:UZLeuven
    Full Title: Prospective Randomised Double-blind Sham Study on the Use of Botox for the Treatment of Diffuse esophageal spasm
    Medical condition: the effect of Botox on symptoms and manometry patterns in patients with diffuse esophageal spasm.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10015390 Esophageal spasm LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-001853-41 Sponsor Protocol Number: 57698 Start Date*: 2018-09-19
    Sponsor Name:Academic Medical Center
    Full Title: Intensive endoscopic therapy versus conventional treatment for untreated benign anastomotic strictures after esophagectomy: a pilot and randomized controlled trial
    Medical condition: Benign esophagogastric anastomotic strictures after esophagectomy
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004856 10030199 Oesophageal stricture LLT
    20.0 100000004856 10015449 Esophageal stricture LLT
    20.0 10042613 - Surgical and medical procedures 10030215 Oesophagectomy PT
    20.0 10042613 - Surgical and medical procedures 10015460 Esophagectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-005856-33 Sponsor Protocol Number: AT10008 Start Date*: 2007-02-13
    Sponsor Name:The Department of Molecular Medicin and Surgery, P9:03, Karolinska Institutet
    Full Title: Local Glucocorticoid Injektion in the Treatment of Benign Oesophageal Strictures, a Randomized Clinical Study
    Medical condition: Patients with benign oesophageal strictures and symptoms where dilatation of the stricture is planned.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10030199 Oesophageal stricture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006081-29 Sponsor Protocol Number: Rimonaslok Start Date*: 2008-10-21
    Sponsor Name:UZLeuven
    Full Title: INFLUENCE OF RIMONABANT ON LOWER ESOPHAGEAL FUNCTION IN HEALTHY VOLUNTEERS
    Medical condition: none; this is a physiological study to investigate the influence of CB1 receptor antagonism by rimonabant (normally used for the treatment of obesity) on esophageal function, i.e. esophageal contr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-011174-15 Sponsor Protocol Number: 2700/2008 Start Date*: 2009-03-16
    Sponsor Name:AZIENDA OSPEDALIERA PISANA
    Full Title: PRE-OPERATIVE CHEMO-RADIOTHERAPIC TREATMENT IN ESOPHAGEAL AND GASTRO-ESOPHAGEAL JUNCTION ADENOCARCINOMA
    Medical condition: ESOPHAGEAL AND GASTRO-ESOPHAGEAL JUNCTION ADENOCARCINOMA
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061882 LLT
    9.1 10030137 PT
    9.1 10066350 LLT
    9.1 10061882 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-004633-24 Sponsor Protocol Number: PCT Start Date*: 2008-10-23
    Sponsor Name:Women's and Children's Hospital
    Full Title: A trial of position control therapy (PCT) for treatment of infantile gastro-oesophageal reflux
    Medical condition: gastro-oesophageal reflux related symptoms
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017884 Gastrooesophageal reflux LLT
    9.1 10017885 Gastrooesophageal reflux disease LLT
    9.1 10017924 Gastroesophageal reflux LLT
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-004155-35 Sponsor Protocol Number: A7421007 Start Date*: 2005-12-01
    Sponsor Name:Pfizer Limited
    Full Title: A randomized, double blind, parallel group study to examine the effect of multiple doses of CJ-040,714 on distal esophageal acid exposure an patients with erosive gastro-esophageal reflux disease (...
    Medical condition: Gastro-Esophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    8.0 10017885 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-004501-25 Sponsor Protocol Number: D9120C00020 Start Date*: 2006-12-18
    Sponsor Name:AstraZeneca AB
    Full Title: A double-blind, placebo controlled, randomized, two centre phase IIa pharmacodynamic cross-over study to assess the effect of AZD3355, 65 mg bid, on transient lower esophageal sphincter relaxations...
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-013080-19 Sponsor Protocol Number: 27538 Start Date*: 2010-03-31
    Sponsor Name:AMC
    Full Title: Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease
    Medical condition: gastro-esophageal reflux disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000479 Acid reflux (oesophageal) LLT
    9.1 10017884 Gastrooesophageal reflux LLT
    9.1 10017885 Gastrooesophageal reflux disease LLT
    9.1 10038262 Reflux esophagitis LLT
    9.1 10020024 Hiatal hernia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-018608-98 Sponsor Protocol Number: D3830C00001 Start Date*: 2010-06-09
    Sponsor Name:AstraZeneca AB
    Full Title: A double-blind, randomized, placebo-controlled, two-centre, phase IIa pharmacodynamic cross-over study to assess the effect of AZD2516 on the total number of reflux episodes in healthy male volunteers
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    12.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults Gender: Male
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-003131-38 Sponsor Protocol Number: DOPA2016 Start Date*: 2017-06-23
    Sponsor Name:TARGID, KU Leuven
    Full Title: The effect of chlorpromazine (Largactil), a dopamine type 2-(D2-) receptor antagonist, on esophageal sensitivity in healthy volunteers: a randomized, double-blind, placebo-controlled study
    Medical condition: Increased esophageal sensitivity in refractory gastro-esophageal reflux disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2013-004232-29 Sponsor Protocol Number: UZBLANREOTIDE01 Start Date*: 2014-01-02
    Sponsor Name:UZ Brussel
    Full Title: A phase II proof of concept study to evalute the efficacy and safety of deep subcutaneous lanreotide Autogel 120 mg / 28 days on symptoms and healing of the esophageal and gastric mucosa in patient...
    Medical condition: patients with persistent endoscopic reflux in spite of maximal medical therapy with PPI 2 x 40 mg pantoprazole before breakfast and dinner and 300 mg of H2 blocker ranitidine at bedtime AND continu...
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004856 10017924 Gastroesophageal reflux LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-005787-58 Sponsor Protocol Number: eCaEP2021 Start Date*: 2021-05-12
    Sponsor Name:Michael Patrick
    Full Title: Endoscopic assisted Calcium electroporation in esophageal cancer – a safety study
    Medical condition: Esophageal cancer
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10015362 Esophageal cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2005-003485-42 Sponsor Protocol Number: BY1023/M3-341 Start Date*: 2006-03-24
    Sponsor Name:ALTANA Pharma AG
    Full Title: Treatment response in patients with symptoms due to gastroesophageal reflux disease either with or without esophagitis treated with pantoprazole sodium 40 mg o.d. over 8 weeks
    Medical condition: gastroesophageal reflux disease
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017885 llt
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) DE (Completed) ES (Completed) GB (Completed) IT (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2015-005556-10 Sponsor Protocol Number: CA209-577 Start Date*: 2016-05-24
    Sponsor Name:Bristol-Myers Squibb International Corporation
    Full Title: A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
    Medical condition: Subjects with resected adenocarcinoma or squamous cell carcinoma esophageal or gastroesophageal junction cancer
    Disease: Version SOC Term Classification Code Term Level
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10015362 Esophageal cancer LLT
    20.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10062878 Gastrooesophageal cancer PT
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10030191 Oesophageal squamous cell carcinoma stage III PT
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10030190 Oesophageal squamous cell carcinoma stage II PT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10030143 Oesophageal adenocarcinoma stage II PT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10030144 Oesophageal adenocarcinoma stage III PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) ES (Ongoing) CZ (Trial now transitioned) GB (GB - no longer in EU/EEA) IE (Trial now transitioned) DE (Trial now transitioned) BE (Trial now transitioned) DK (Trial now transitioned) NL (Trial now transitioned) RO (Trial now transitioned) FR (Trial now transitioned) IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-006647-31 Sponsor Protocol Number: ASSO OE-1 Start Date*: 2007-08-03
    Sponsor Name:The Austrian Society of Surgical Oncology (ACO-ASSO)
    Full Title: p53-Adjusted Neoadjuvant Chemotherapy for potentially resectable Oesophageal Cancer "pANCHO".
    Medical condition: Interaction between a predictive marker and response to induction chemotherapy in patients with potentially resectable esophageal cancer Predictive Marker Trial
    Disease: Version SOC Term Classification Code Term Level
    9.1 10015362 Esophageal cancer LLT
    Population Age: Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000926-30 Sponsor Protocol Number: BY1023/M3-343 Start Date*: Information not available in EudraCT
    Sponsor Name:ALTANA Pharma AG
    Full Title: Investigation of clinical endpoints for treatment-induced gastroesophageal reflux disease (GERD) symptom changes
    Medical condition: gastroesophageal reflux disease
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017885 Gastrooesophageal reflux disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) AT (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2008-002646-35 Sponsor Protocol Number: M0003-C101 Start Date*: 2008-08-06
    Sponsor Name:Movetis NV
    Full Title: A prospective phase 1, single-dose, open-label, multi-centre clinical trial to evaluate the pharmacokinetics and safety of M0003 in young children aged between 1 and 36 months.
    Medical condition: Intended indication for product under development: Infant gastro-oesophageal reflux disease (GORD)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017885 Gastrooesophageal reflux disease LLT
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed) NL (Not Authorised) GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-002031-92 Sponsor Protocol Number: EX0307 Start Date*: Information not available in EudraCT
    Sponsor Name:Otto-von-Guericke University
    Full Title: Proliferation and differentiation markers, involved in erosive and non-erosive reflux esophagitis, Barrett´s esophagus and esophageal adenocarcinoma.
    Medical condition: Dyspeptic Symptoms GERD (gastroesophageal reflux disease), NERD (non erosive reflux disease), ERD (erosive reflux disease), Barretts esophagus, Adeno-CA of the esophagus
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017885 Gastrooesophageal reflux disease PT
    9.1 10004137 Barrett's oesophagus PT
    9.1 10001173 Adenocarcinoma of esophagus LLT
    9.1 10013949 Dyspeptic signs and symptoms HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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