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Clinical trials for Intrathecal

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    279 result(s) found for: Intrathecal. Displaying page 1 of 14.
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    EudraCT Number: 2006-005614-12 Sponsor Protocol Number: 10.0 Start Date*: 2007-05-18
    Sponsor Name:Medical University Vienna
    Full Title: CSE at Vaginal Delivery - MLAD of Ropivacain and the Effect of Sufentanil
    Medical condition: Dose-finding study of Ropivacain 5% with different doses of Sufentanil intrathecal at the combined spinal epidural anesthesia at labouring patients. If patients are requesting analgesia during labo...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2010-023528-25 Sponsor Protocol Number: 2010-023528-25 Start Date*: 2010-12-23
    Sponsor Name:CHU Brugmann
    Full Title: Etude clinique prospective randomisée en double aveugle de phase 4 comparant la durée d'analgésie postopératoire du fentanyl et du sufentanil administrés comme adjuvant en rachianesthésie dans le c...
    Medical condition: Pregnant patients with a planned caesarian.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10067385 Spinal analgesia LLT
    Population Age: Adults Gender: Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2015-001673-40 Sponsor Protocol Number: 2015/96 Start Date*: 2015-06-29
    Sponsor Name:Oslo University Hospital
    Full Title: INTRATHECAL CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING
    Medical condition: Cerebrospinal fluid circulation disorder seen in the following clinical disease states: Communicating hydrocephalus, idiopathic intracranial hypertension, idiopathic intracranial hypotension, intra...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-004982-32 Sponsor Protocol Number: LIPDEP-001 Start Date*: 2007-06-27
    Sponsor Name:Medical University of Vienna, Department of Pedatrics
    Full Title: Cerebrospinal fluid (CSF) and plasma pharmocokinetics of liposomal cytarabine (DepoCyte®) after intrathecal administration in children with malignant brain tumors and leptomeningeal dissemination
    Medical condition: To measure concentrations of liposomal cytarabine in CSF and plasma over time after intrathecal administration of liposomal cytarabine in children of different age groups with a malignant brain tum...
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2020-005542-42 Sponsor Protocol Number: 2020/11 Start Date*: 2021-03-11
    Sponsor Name:Region Västerbotten
    Full Title: Intrathecal contrast-enhanced MRI for investigation of cerebrospinal fluid transportation
    Medical condition: Cerebrospinal fluid circulation disorder seen in clinically suspected idiopathic normal pressure hydrocephalus
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012928-89 Sponsor Protocol Number: 1.1042009 Start Date*: 2009-10-21
    Sponsor Name:South Tees NHS Trust
    Full Title: Intrathecal injection of a single dose of Ziconotide (Prialt®) to evaluate the option of continuous administration via implanted pump. A Pilot Study
    Medical condition: Severe, Chronic pain in patients who require intrathecal analgesia
    Disease: Version SOC Term Classification Code Term Level
    101 10049475 Chronic pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-005222-41 Sponsor Protocol Number: 04/Q2803/72 Start Date*: 2005-08-26
    Sponsor Name:UHCW NHS Trust
    Full Title: Intrathecal Morphine for pain management in patients undergoing major abdominal surgery: The optimal dose?
    Medical condition: The use of intrathecal morphine for post-operative pain relief following major abdominal surgery - the comparison of two doses (10 micrograms/kg and 20 micrograms/kg) medical condition = post-oper...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-011458-16 Sponsor Protocol Number: N/A Start Date*: 2009-09-10
    Sponsor Name:North Wales NHS Trust
    Full Title: Comparison of efficacy and side effects of intrathecal fentanyl with intrathecal morphine
    Medical condition: Analgesia
    Disease: Version SOC Term Classification Code Term Level
    9.1 10002182 Analgesia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-005087-14 Sponsor Protocol Number: CPP-401 Start Date*: 2008-11-12
    Sponsor Name:Centre Paul Papin
    Full Title: Comparison of 2 morphine administration’s mode using Pump IntraThecal (IDDS)for Analgesia in patients with Cancer pain, resistant to conventional antalgic treatment
    Medical condition: Patients with intractable cancer pain, either uncontrolled with standard analgesia , or undergoing severe side effects due to analgesia . Patients undergo implantation of a Medtronic intrathecal pu...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    9.1 10059050 Intractable pain LLT
    Population Age: Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-000767-28 Sponsor Protocol Number: 20061 Start Date*: 2006-09-29
    Sponsor Name:Vienna Medical University
    Full Title: Standardisierte Verlaufsbeobachtung von Patienten mit intrathekalem S(+)-Ketamin
    Medical condition: Intrathecal S(+)-ketamine is a potent option in the treatment of chronic severe neuropathic pain in cancer patients refractory to conventional therapeutic strategies (Benrath et al. 2005). However,...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2006-002565-39 Sponsor Protocol Number: 2006015 Start Date*: 2006-11-27
    Sponsor Name:South Tees Acute Hospitals NHS Trust
    Full Title: Effects of the Modification of the Daily Flow Rate with a Constant Daily Dose on Patient's Reported Analgesia in Intathecal Therapy
    Medical condition: Chronic Pain.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-002559-27 Sponsor Protocol Number: 2017-03 Start Date*: 2018-03-29
    Sponsor Name:Zaans Medisch Centrum
    Full Title: ED50 and ED90 of intrathecal 1% chloroprocaine in day-case knee arthroscopy
    Medical condition: Patients scheduled for ambulatory knee arthroscopy surgery receive intrathecal chloroprocaine
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-004822-29 Sponsor Protocol Number: CHL1/02-2004 Start Date*: 2005-03-09
    Sponsor Name:SINTETICA SA
    Full Title: Spinal anaesthesia with 2 -chlopoprocaine 1% for lower limb procedures of short duration: a prospective randomized, blind, dose-finding study.
    Medical condition: Spinal anaesthesia for short therm surgical procedures
    Disease: Version SOC Term Classification Code Term Level
    6.1 10041536 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004436-36 Sponsor Protocol Number: Rituximab1.5 Start Date*: 2013-04-19
    Sponsor Name:Odense University Hospital
    Full Title: A prospective pilotstudy of immunological and radiological effects of intrathecal rituximab in patients with secondary progressive multiple sclerosis
    Medical condition: Multiple Sclerosis
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10063400 Secondary progressive multiple sclerosis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-004934-26 Sponsor Protocol Number: N/A Start Date*: 2008-11-26
    Sponsor Name:UMCG
    Full Title: Pharmacokinetics and –dynamics of intrathecal baclofen therapy in patients with spasticity
    Medical condition: Spasticity of varying origin (i.e. MS, spinal cord injury), which doesn't respond on treatment with oral medication
    Disease: Version SOC Term Classification Code Term Level
    9.1 10041416 Spasticity LLT
    9.1 10024132 Leg spasticity LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004427-31 Sponsor Protocol Number: TAFCNS2015 Start Date*: 2016-03-07
    Sponsor Name:Gothenburg University
    Full Title: Tenofovir Alafenamide Fumarate (TAF) effect on residual intrathecal immune activation
    Medical condition: HIV-infection in the central nervous system
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000702-71 Sponsor Protocol Number: PreSpiDi2006-01 Start Date*: 2007-07-13
    Sponsor Name:Alysis Zorggroep
    Full Title: The effect of intravenous fluid preload on diuresis during spinal anesthesia-induced detrusor blockade
    Medical condition: Diuresis during spinal anesthesia
    Disease: Version SOC Term Classification Code Term Level
    9.1 10041538 Spinal anesthesia LLT
    9.1 10013523 Diuresis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-000212-25 Sponsor Protocol Number: HGT-HIT-046 Start Date*: 2012-01-05
    Sponsor Name:Shire HGT Inc
    Full Title: An Open-Label Extension of Study HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Intrathecal Idursulfase-IT Administered in Conjunction with Intravenous Elaprase® in Pediatric Pati...
    Medical condition: Treatment of Hunter syndrome and cognitive impairment
    Disease: Version SOC Term Classification Code Term Level
    20.1 10010331 - Congenital, familial and genetic disorders 10056889 Mucopolysaccharidosis II PT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male
    Trial protocol: GB (GB - no longer in EU/EEA) Outside EU/EEA
    Trial results: (No results available)
    EudraCT Number: 2010-018920-21 Sponsor Protocol Number: ZICBOL2010 Start Date*: 2011-03-23
    Sponsor Name:Landstinget i Östergötland
    Full Title: Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide(Prialt®) - The Swedish Ziconotide Bolus Study
    Medical condition: Chronic pain
    Disease: Version SOC Term Classification Code Term Level
    12.1 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-001176-37 Sponsor Protocol Number: 07/S1401/27 Start Date*: 2007-05-29
    Sponsor Name:NHS Tayside
    Full Title: A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the firs...
    Medical condition: Pain in early labour
    Disease: Version SOC Term Classification Code Term Level
    9.1 10054891 Epidural analgesia LLT
    9.1 10041536 Spinal anaesthesia LLT
    9.1 10059204 Labour pain LLT
    Population Age: Adults Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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