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Clinical trials for L-NMMA

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    15 result(s) found for: L-NMMA. Displaying page 1 of 1.
    EudraCT Number: 2006-000734-13 Sponsor Protocol Number: V 1.0 Start Date*: 2006-07-31
    Sponsor Name:Department of Clinical Pharmacology
    Full Title: Effect of L-NMMA on retinal and choroidal blood flow in smokers compared to non-smokers.
    Medical condition: 24 healthy male and female volunteers, age 18-35 yrs., smokers (at least 10 cigarettes/day since 2 years) 24 healthy male and female volunteers, age 18-35 yrs., nonsmokers (since at least 2 years).
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-001670-27 Sponsor Protocol Number: CSO1 Start Date*: 2005-11-14
    Sponsor Name:Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship
    Full Title: Reversibility of cerebrovascular endothelial dysfunction in diabetes: the role of allopurinol.
    Medical condition: Type Two Diabetes Mellitus
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-002278-30 Sponsor Protocol Number: CRC2012LINA Start Date*: 2012-08-13
    Sponsor Name:University Hospital Erlangen
    Full Title: Effects of Linagliptin on Renal Endothelium Function in Patients with Type 2 Diabetes.
    Medical condition: Diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    14.1 10027433 - Metabolism and nutrition disorders 10012613 Diabetes mellitus non-insulin-dependent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2005-005896-14 Sponsor Protocol Number: Version 1.0 Start Date*: 2006-02-20
    Sponsor Name:Department of Clinical Pharmacology
    Full Title: Role of endothelin- and nitric oxide-system in the regulation of optic nerve head blood flow during changes in ocular perfusion pressure
    Medical condition: 18 healthy male volunteers Age 18-35 yrs., nonsmokers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-003958-94 Sponsor Protocol Number: CVAH631BDE06 Start Date*: 2005-12-02
    Sponsor Name:Novartis Phama GmbH
    Full Title: A randomized, open-label, multicenter, cross-over trial to evaluate the efficacy of a 20 week treatment of Valsartan 320 mg (Diovan) versus Atenolol 100 mg in combination with Hydrochlorothiazide o...
    Medical condition: Essential mild-to-moderate hypertension
    Disease: Version SOC Term Classification Code Term Level
    M15 10020772 LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2017-002268-42 Sponsor Protocol Number: 205767 Start Date*: 2018-03-29
    Sponsor Name:GlaxoSmithKline Research & Development Ltd
    Full Title: A randomized, repeat dose, open label, parallel group, multi-center study to evaluate the effect of daprodustat compared to darbepoetin alfa on forearm blood flow in participants with anemia of chr...
    Medical condition: anemia associated with chronic kidney disease
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038359 - Renal and urinary disorders 10064848 Chronic kidney disease PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-017676-24 Sponsor Protocol Number: CSPP100ADE07T Start Date*: 2010-02-26
    Sponsor Name:University Hospital Erlangen
    Full Title: Randomized, double blind, active-controlled, parallel study to analyse effects of the combination of aliskiren and valsartan on the vascular structure and function of retinal vessels
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    12.1 10020772 Hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-018495-25 Sponsor Protocol Number: EBP-FHC-2010-1 Start Date*: 2010-05-12
    Sponsor Name:Medicinsk Forskning
    Full Title: Effekten af atorvastatin på NO-systemet hos raske kontrol personer
    Medical condition: Effekten af atorvastin på NO-systemet under på raske forsøgspersoner
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018979-16 Sponsor Protocol Number: SAXA24011980GLIPTIN Start Date*: 2010-08-23
    Sponsor Name:University Hospital Erlangen
    Full Title: EFFECTS OF SAXAGLITPIN ON ENDOTHELIAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES
    Medical condition: diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    12.1 10012613 Diabetes mellitus non-insulin-dependent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-019206-16 Sponsor Protocol Number: EBP-FHC-2010-3 Start Date*: 2010-05-12
    Sponsor Name:Medicinsk Forskning, Regionshospitalet Holstebro
    Full Title: Effekten af atorvastatin på NO-systemet patienter med type 2 diabetes med nefropati
    Medical condition: Diabetisk Nefropati Formålet er at måle effekten af atorvastatin på L-NMMA inducerede ændringer i den renale tubulære transport af natrium og vand , central hæmodynamik og vasoaktive hormoner hos...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10012638 Diabetes with renal manifestations LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017619-14 Sponsor Protocol Number: EBP_TL_2009 Start Date*: 2010-03-26
    Sponsor Name:Medicinsk Forskningsafsnit, Holstebro
    Full Title: RENO- OG KREDSLØBSPROTEKTIV EFFEKT AF VITAMIN-D-ANALOG (PARICALCITOL) HOS PATIENTER MED MODERAT TIL SVÆR KRONISK NYREINSUFFICIENS
    Medical condition: The aim is to measure the effect of paricalcitol given orally in patients with moderate to severe chronic kidney diseases (CKD stage III-IV i.e. eGFR:15-59 ml/min) investigating vasoactive hormones...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10064848 Chronic kidney disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-016738-28 Sponsor Protocol Number: ALISEI Start Date*: 2009-12-11
    Sponsor Name:AZIENDA OSPEDALIERA PISANA
    Full Title: Phase IV prospective, randomized, open with blind endpoints, parallel group study to evaluate the effect of Aliskiren on endothelial dysfunction in patients with essential hypertension
    Medical condition: essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    12.0 10015488 Essential hypertension LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001131-31 Sponsor Protocol Number: FHC-1-2012 Start Date*: 2012-06-14
    Sponsor Name:Department of Medical Research
    Full Title: Effekts of nebivolol on the nitric oxide system in patients with essentiel hypertension
    Medical condition: Essential Hypertension
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10015488 Essential hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-019202-17 Sponsor Protocol Number: EBP-FHC-2010-2 Start Date*: 2010-05-12
    Sponsor Name:Medicinsk Forskning
    Full Title: Effekten af atorvastatin på NO-systemet hos patienter med non-diabetisk nefropati
    Medical condition: Kronisk nyresygdom, dvs. kliniske, biokemiske eller billeddiagnostiske tegn på nyresygdom i mere end 3 måneder Mikroalbuminuri (u-alb/u-creatinin 2,5-24 mg/mmol kreatinin) eller albuminuri (u-alb/u...
    Disease: Version SOC Term Classification Code Term Level
    12.1 10029151 Nephropathy LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001169-33 Sponsor Protocol Number: SAFA-1-2012 Start Date*: 2012-07-02
    Sponsor Name:Department of Medical Research
    Full Title: Effects of tolvaptan on renal sodium and water handling and circulation during inhibition of the nitric oxide system in healthy subjects
    Medical condition: SIADH (Syndrome of inappropriate ADH production) Overhydration Hyponatrimia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10027433 - Metabolism and nutrition disorders 10021038 Hyponatremia LLT
    14.1 10014698 - Endocrine disorders 10040626 SIADH LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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