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Clinical trials for Melatonin

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44351   clinical trials with a EudraCT protocol, of which   7378   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    82 result(s) found for: Melatonin. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2017-000997-13 Sponsor Protocol Number: HEHDZ01 Start Date*: 2018-03-02
    Sponsor Name:Center for Perioperative Optimization, Department of Surgery, Herlev Hospital
    Full Title: Pharmacokinetics of intravenous, rectal, intravesical, vaginal, and transdermal administration of exogenous melatonin in healthy female volunteers: a crossover study
    Medical condition: Pharmacokinetics of melatonin
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10053349 Pharmacokinetic study LLT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2016-000606-11 Sponsor Protocol Number: 5502071979 Start Date*: Information not available in EudraCT
    Sponsor Name:Region Ostergotland
    Full Title: Melatonin compared to sleep deprivation for sleep EEG recordings in children: impact on epileptiform discharges and sleep, contributing factors on the results and the influence on children's and pa...
    Medical condition: suspected epilepsy
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017075-24 Sponsor Protocol Number: me-09 Start Date*: 2009-12-16
    Sponsor Name:Natural Pharma International Npi AB
    Full Title: Delayed sleep phase in adolescents - effects of melatonin treatment
    Medical condition: delayed sleep phase
    Disease: Version SOC Term Classification Code Term Level
    12.0 10012209 Delayed sleep phase LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-004048-50 Sponsor Protocol Number: 3-062-18 Start Date*: 2019-02-14
    Sponsor Name:University of Aberdeen [...]
    1. University of Aberdeen
    2. NHS Grampian
    Full Title: Double blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP)
    Medical condition: Sleep disturbance in patients with chronic pain
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004873 10040995 Sleep disturbance LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2013-003023-10 Sponsor Protocol Number: 03072013 Start Date*: 2013-10-07
    Sponsor Name:Department of Surgery, Herlev Hospital
    Full Title: MELATOX: Pharmacodynamic evaluation of topical use of melatonin as sun protection: a randomized, double blinded, placebo controlled crossover study on healthy volunteers.
    Medical condition: Adverse effects of topical use of melatonin as sun protection.
    Disease: Version SOC Term Classification Code Term Level
    16.0 10018065 - General disorders and administration site conditions 10060933 Adverse event PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007156-33 Sponsor Protocol Number: CRO970 (MIND) Start Date*: 2008-05-23
    Sponsor Name:Imperial College
    Full Title: Melatonin As A Novel Neuroprotectant in Preterm Infants- Dosage study
    Medical condition: Brain Injury in Preterm Infants
    Disease: Version SOC Term Classification Code Term Level
    9.1 10013384 Disorders relating to short gestation and unspecified low birthweight LLT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-005255-17 Sponsor Protocol Number: Start Date*: 2014-09-05
    Sponsor Name:University of Leeds
    Full Title: Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European population
    Medical condition: first-degree relatives of individuals with type 2 diabetes.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-004442-11 Sponsor Protocol Number: JAZ-01 Start Date*: 2020-12-01
    Sponsor Name:Zealand University Hospital
    Full Title: The effect of Melatonin in patients with Low Anterior Resection Syndrome
    Medical condition: Low anterior resection syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.1 10022117 - Injury, poisoning and procedural complications 10080023 Low anterior resection syndrome PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002840-42 Sponsor Protocol Number: 3/035/14 Start Date*: 2014-12-15
    Sponsor Name:University of Aberdeen [...]
    1. University of Aberdeen
    2. NHS Grampian
    Full Title: Dose assessment of melatonin in sepsis trial (DAMSEL 2)
    Medical condition: Sepsis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10021881 - Infections and infestations 10053879 Sepsis syndrome PT
    Population Age: Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2011-005360-22 Sponsor Protocol Number: 2 Start Date*: 2012-06-29
    Sponsor Name:Vasa HVC
    Full Title: Does melatonin (CircadinR) worsen glucose tolerance in individuals with at (rs10830963) variant in the melatonin receptor 1B (MTNR1B) gene?
    Medical condition: Impaired glucose tolerance in healthy study persons
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-004160-16 Sponsor Protocol Number: PBKV.8zdnia01.06.2022 Start Date*: 2024-02-22
    Sponsor Name:The Pharmaceutical Company LEK-AM Sp. Zoo.
    Full Title: A randomized, double-blind, placebo-controlled, multicenter study evaluating the effect of a 12-week DHEA combination of 20 mg and 2 mg prolonged-release melatonin on sleep quality an...
    Medical condition: Menopause, sleep disorders in the postmenopausal period
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: PL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-005986-36 Sponsor Protocol Number: 7977 Start Date*: Information not available in EudraCT
    Sponsor Name:University of Bergen
    Full Title: DELAYED SLEEP PHASE SYNDROME. SLEEP, PERSONALITY, DEVELOPMENTAL HISTORY, CIRCADIAN RHYTHM AND TREATMENT
    Medical condition: Delayed sleep phase syndrome - DSPS.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012209 Delayed sleep phase LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NO (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005308-15 Sponsor Protocol Number: n/a Start Date*: 2007-03-15
    Sponsor Name:University Heidelberg, Department of General Surgery
    Full Title: Pilot study of the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection.
    Medical condition: postoperative infectious complications ICD classification code : T 81.4
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2020-001808-42 Sponsor Protocol Number: PHM-2020-001 Start Date*: 2020-06-17
    Sponsor Name:Pharmamel S.L.
    Full Title: PHASE II CLINICAL TRIAL, SINGLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TO EXPLORE THE EFFECTIVENESS AND SAFETY OF MELATONIN I.V. IN PATIENTS WITH COVID-19 ENTERED INTO THE ICU (MELCOVID STUDY)
    Medical condition: COVID-19 infection
    Disease: Version SOC Term Classification Code Term Level
    23.0 10021881 - Infections and infestations 10084268 COVID-19 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2018-001705-91 Sponsor Protocol Number: HEHDZ02 Start Date*: 2018-09-26
    Sponsor Name:Center for Perioperative Optimization, Department of Surgery, Herlev Hospital
    Full Title: MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer: a pivotal phase 2, double-blind, randomized, placebo-controlled trial
    Medical condition: Radiation dermatitis
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10061103 Dermatitis radiation LLT
    20.1 10022117 - Injury, poisoning and procedural complications 10063562 Radiation skin injury PT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-000629-30 Sponsor Protocol Number: 06022013 Start Date*: 2013-04-09
    Sponsor Name:Department of surgery, Herlev Hospital
    Full Title: The sun protective effect of melatonin: a randomized, placebo-controlled, double-blinded study on healthy volunteers.
    Medical condition: Erythema after sun exposure in healthy volunteers
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004858 10045745 Unspecified dermatitis due to sun LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-006452-22 Sponsor Protocol Number: maple b Start Date*: 2009-04-01
    Sponsor Name:Academic Medical Centre
    Full Title: The effects of melatonin in the treatment of delirium
    Medical condition: Delirium in elderly patients (65 yrs and older) acutely admitted to the ward of internal medicine.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012218 Delirium LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-002187-31 Sponsor Protocol Number: 03-08022022 Start Date*: 2021-11-19
    Sponsor Name:Department of Paediatrics, Herlev Hospital
    Full Title: A parallel group, double-blinded randomised multi dose pharmacokinetic and safety study of melatonin in children and adolescents
    Medical condition: Healthy children and adolescents
    Disease: Version SOC Term Classification Code Term Level
    22.0 10022891 - Investigations 10022891 Investigations SOC
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: DK (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-000220-18 Sponsor Protocol Number: C.2524.0472.01 Start Date*: 2013-03-25
    Sponsor Name:University of Amsterdam
    Full Title: Effects of melatonin treatment, light therapy, and sleep improvement on psychosocial, cognitive, and behavioural outcomes in children with Delayed Sleep Phase Syndrome and their parents
    Medical condition: Delayed Sleep Phase Syndrome
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006782-83 Sponsor Protocol Number: EC08/00230 Start Date*: 2013-09-24
    Sponsor Name:Hospital Universitario Virgen de las Nieves
    Full Title: Prevention MODS by modulating the inflammatory response through melatonin administration in surgical patients with severe sepsis.
    Medical condition: Septic patients of abdominal surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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