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Clinical trials for Metabolic Disease

The European Union Clinical Trials Register allows you to search for protocol and results information on:
  • interventional clinical trials that are conducted in the European Union (EU) and the European Economic Area (EEA);
  • clinical trials conducted outside the EU / EEA that are linked to European paediatric-medicine development.
  • Learn   more about the EU Clinical Trials Register   including the source of the information and the legal basis.


    The EU Clinical Trials Register currently displays   36800   clinical trials with a EudraCT protocol, of which   6077   are clinical trials conducted with subjects less than 18 years old.
    The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    Query did not match any clinical trials.
    These are paediatric studies completed by 26 January 2007, in respect of products authorised in the Community (Article 45 of the Paediatric Regulation (EC) No 1901/2006).
    Note: Advanced search filters for country, trial phase, gender, rare disease, IMP with orphan designation in the indication and age ranges of in-utero, adult or elderly do not apply to these records.
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    Study title: Appendix I to Ephynal (dl-α-tocopherol) NDA pharmacokinetic profile (for Vitamin E) in premature neonated following intramuscular administration
    Active substance: TOCOPHEROL
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    Document reference: 47788
    Study title: Kalra V. Vitamin E Administration and Reversal of Neurological Deficits in Protein-Energy Malnutrition. Journal of Tropical Pediatrics 2001; 47: 39-48. Kalra V. Vitamin E Administration and Reversal of Neurological Deficits in Protein-Energy Malnutrition. Journal of Tropical Pediatrics 2001; 47: 39-48.
    Active substance: TOCOPHEROL
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    Document reference: 44822
    Study title: Pharmacokinetic profile for vitamin E in premature neonated following intramuscular administration
    Active substance: TOCOPHEROL
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    Document reference: 44823
    Study title: Tolerability and acceptability of Ro 01-4065/342, EPHYNAL effervescent tablets
    Active substance: TOCOPHEROL
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    Document reference: 47790
    Study title: "Symmetrical Transformation zones in infant rickets (Milkman syndrome?)", Kosenow W., Zeitschrift fur kinderheilkunde, 1951, 69 : 191-206"Symmetrical Transformation zones in infant rickets (Milkman syndrome?)", Kosenow W., Zeitschrift fur kinderheilkunde, 1951, 69 : 191-206
    Active substance: OSSEIN HYDROXYAPATITE COMPOUND
    Study summary document link (including results): Ossopan nr8.xls
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    Document reference: 47721
    Study title: "The influence of a whole-bone preparation on the growth of dystrophic children", Gotti D. & Nicolaj P., La clinica Pediatrica, 1951, N°5, 33 "The influence of a whole-bone preparation on the growth of dystrophic children", Gotti D. & Nicolaj P., La clinica Pediatrica, 1951, N°5, 33
    Active substance: OSSEIN HYDROXYAPATITE COMPOUND
    Study summary document link (including results): Ossopan nr7.xls
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    Document reference: 47720
    Study title: "The use of powdered raw bone of young animals in children", Cornet-Jacquemoud C., Moderne Probleme der Pediatrie, 1954, 1 : 245-251"The use of powdered raw bone of young animals in children", Cornet-Jacquemoud C., Moderne Probleme der Pediatrie, 1954, 1 : 245-251
    Active substance: OSSEIN HYDROXYAPATITE COMPOUND
    Study summary document link (including results): Ossopan nr6.xls
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    Document reference: 47719
    Study title:
    Active substance: PHENYLEPHRINE AND PREDNISOLONE_PHENYEPHRINE ANDZINC SULPHATE
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    Document reference: 33954
    Study title: Extract of submission to the UK's Food Standards Agency - P. Holford et al. - 2003 (Journal of Orthomolecular Medicine vol 18) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31482
    Study title: Institute of Medicine (US). Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Food and Nutrition Board. Dietary Reference Intakes for folate, other B vitamins, and choline. - no author - 1999 (Washington DC : National Academy Press) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Institute of Medicine (US). Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Food and Nutrition Board. Dietary Reference Intakes for folate, other B vitamins, and choline. - no author - 1999 (Washington DC : National Academy Press) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised dur...
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31489
    Study title: Treatment of the West syndrome with high-dose pyridoxal phosphate - Y. Ohtsuka et al. - 1987 (Brain Dev vol 9) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Treatment of the West syndrome with high-dose pyridoxal phosphate - Y. Ohtsuka et al. - 1987 (Brain Dev vol 9) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31501
    Study title: Vitamin B6, Magnesium and combined B6-Mg : therapeutic effects in childhood autism - J. Martineau et al. - 1985 (Biol. Psychiatry vol 20) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Vitamin B6, Magnesium and combined B6-Mg : therapeutic effects in childhood autism - J. Martineau et al. - 1985 (Biol. Psychiatry vol 20) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31502
    Study title:
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31503
    Study title: Brief report : an open middle term study of combined vitamin B6 - Magnesium in a subgroup of autistic children selected on their sensitivity to this treatment - J. Martineau et al. - 1988 ( Journal of Autitism and Developmental disorders vol 18) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
    Study summary document link (including results): Mg lactate_mg pidolate_pyridoxine chlorhydrate STUDY 246-6-004.xls
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    Document reference: 31504
    Study title: Pyridoxine treatment in a subgroup of children with pervasive developmental disorders - S. Kuriyama et al. - 2002 (Developmental Medicine and Child Neurology vol 44) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Pyridoxine treatment in a subgroup of children with pervasive developmental disorders - S. Kuriyama et al. - 2002 (Developmental Medicine and Child Neurology vol 44) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31491
    Study title: Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behaviour - J. Martineau et al. - 1989 (Developmental Medicine and Child Neurology vol 31) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behaviour - J. Martineau et al. - 1989 (Developmental Medicine and Child Neurology vol 31) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31485
    Study title: European Commission Scientific Committee on Food. Opinion of the Scientific Commitee on Food on the tolerable upper intake leval of vitamin B6 (http : // europa.eu.int/comm/food/fs/sc/scf/index en.htlm) - 11/2000 - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31481
    Study title: Treatment of infantile spasms with high-dosage vitamin B6 - J. Pietz et al. - 1993 (Epilepsia vol 34) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Treatment of infantile spasms with high-dosage vitamin B6 - J. Pietz et al. - 1993 (Epilepsia vol 34) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31499
    Study title: Treatment of infantile spasms with high-dosage vitamin B6 : the Heidelberg experience 1989-1999 - J. Scholl et al. - 2000 (Neuropediatrics vol 31) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -Treatment of infantile spasms with high-dosage vitamin B6 : the Heidelberg experience 1989-1999 - J. Scholl et al. - 2000 (Neuropediatrics vol 31) - Publication in MAGNE-B6 Magnesium - pyridoxine Tablet & Oral Solution -Response to questions raised during the renewal process in Estonia -Raphaëlle Pivaty- 04/2004 -
    Active substance: MAGNESIUM LACTATE + MAGNESIUM PIDOLATE + PYRIDOXINE (VIT B6)
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    Document reference: 31500
    Study title: Heron-B, Gautier-A, Dulac-O, Ponsot-G. Service de Neurologie Pediatrique, Hopital Saint-Vincent-de-Paul, Paris. Biotinidase deficiency. Progressive encephalopathy curable with biotin. Archives francaises de pediatrie, {Arch-Fr-Pediatr}, Dec 1993, vol. 50, no. 10, p. 875-8, ISSN: 0003-9764.Heron-B, Gautier-A, Dulac-O, Ponsot-G. Service de Neurologie Pediatrique, Hopital Saint-Vincent-de-Paul, Paris. Biotinidase deficiency. Progressive encephalopathy curable with biotin. Archives francaises de pediatrie, {Arch-Fr-Pediatr}, Dec 1993, vol. 50, no. 10, p. 875-8, ISSN: 0003-9764.
    Active substance: BIOTIN
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    Document reference: 22625
    Study title: Kokil-S. Anemia in dermatitis seborrheica and the curative effect of biotin. Annales paediatrici. International review of pediatrics, {Ann-Paediatr}, Feb 1956, vol. 186, no. 2, p. 79-82, ISSN: 0365-4966.Kokil-S. Anemia in dermatitis seborrheica and the curative effect of biotin. Annales paediatrici. International review of pediatrics, {Ann-Paediatr}, Feb 1956, vol. 186, no. 2, p. 79-82, ISSN: 0365-4966.
    Active substance: BIOTIN
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    Document reference: 22589
    Study title: Lemoine-A, Le-Devehat-C, Dougny-M. Serv. Diabetol. Mal. Nutrit., Cent. Hosp. Nevers, 58320 Pougues-les-Eaux, France. Biotine. Gazette Medicale de France {GAZ-MED-FR}, 1983, Vol/Iss/Pg. 90/1 (38-39).Lemoine-A, Le-Devehat-C, Dougny-M. Serv. Diabetol. Mal. Nutrit., Cent. Hosp. Nevers, 58320 Pougues-les-Eaux, France. Biotine. Gazette Medicale de France {GAZ-MED-FR}, 1983, Vol/Iss/Pg. 90/1 (38-39).
    Active substance: BIOTIN
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    Document reference: 22573
    Study title: Munnich-A, Saudubray-J-M, Ogier-H, Marsac-C, Charpentier-C, Frezal-J. Alopecia, chronic candidodis, mental retardation and repeated ketoacidosic comas curable by biotin administration: multiple carboxylases deficiency. Annales de medecine interne, {Ann-Med-Interne-Paris}, 1980, vol. 131, no. 7, p. 435-7, ISSN: 0003-410X.Munnich-A, Saudubray-J-M, Ogier-H, Marsac-C, Charpentier-C, Frezal-J. Alopecia, chronic candidodis, mental retardation and repeated ketoacidosic comas curable by biotin administration: multiple carboxylases deficiency. Annales de medecine interne, {Ann-Med-Interne-Paris}, 1980, vol. 131, no. 7, p. 435-7, ISSN: 0003-410X.
    Active substance: BIOTIN
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    Document reference: 22581
    Study title: Nothjunge-J, Krageloh-Mann-I, Suormala-T-M, Baumgartner-E-R. Abteilung Allgemeine Padiatrie, Universitats-Kinderklinik, Tubingen, Germany. Biotinidase deficiency: A hereditary metabolic disorder successfully treated with biotin. Monatsschrift fur Kinderheilkunde {MONATSSCHR-KINDERHEILKD}, 1989, Vol/Iss/Pg. 137/11 (737-740), ISSN: 0026-9298.Nothjunge-J, Krageloh-Mann-I, Suormala-T-M, Baumgartner-E-R. Abteilung Allgemeine Padiatrie, Universitats-Kinderklinik, Tubingen, Germany. Biotinidase deficiency: A hereditary metabolic disorder successfully treated with biotin. Monatsschrift fur Kinderheilkunde {MONATSSCHR-KINDERHEILKD}, 1989, Vol/Iss/Pg. 137/11 (737-740), ISSN: 0026-9298.
    Active substance: BIOTIN
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    Document reference: 22634
    Study title: Erlichman-M, Goldstein-R, Levi-E, Greenberg-A, Freier-S. Infantile flexural seborrhoeic dermatitis. Neither biotin nor essential fatty acid deficiency. Archives of disease in childhood, {Arch-Dis-Child}, Jul 1981, vol. 56, no. 7, p. 560-2, ISSN: 1468-2044.Erlichman-M, Goldstein-R, Levi-E, Greenberg-A, Freier-S. Infantile flexural seborrhoeic dermatitis. Neither biotin nor essential fatty acid deficiency. Archives of disease in childhood, {Arch-Dis-Child}, Jul 1981, vol. 56, no. 7, p. 560-2, ISSN: 1468-2044.
    Active substance: BIOTIN
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    Document reference: 22577
    Study title: Friebel-D, von-der-Hagen-M, Baumgartner-E-R, Fowler-B, Hahn-G, Feyh-P, Heubner-G, Baumgartner-M-R, Hoffmann-G-F. Department of Neuropaediatrics, Children's Hospital, Technical University of Dresden, Dresden, Germany. The first case of 3-methylcrotonyl-CoA carboxylase (MCC) deficiency responsive to biotin. Neuropediatrics, {Neuropediatrics}, Apr 2006, vol. 37, no. 2, p. 72-8, ISSN: 0174-304X.Friebel-D, von-der-Hagen-M, Baumgartner-E-R, Fowler-B, Hahn-G, Feyh-P, Heubner-G, Baumgartner-M-R, Hoffmann-G-F. Department of Neuropaediatrics, Children's Hospital, Technical University of Dresden, Dresden, Germany. The first case of 3-methylcrotonyl-CoA carboxylase (MCC) deficiency responsive to biotin. Neuropediatrics, {Neuropediatrics}, Apr 2006, vol. 37, no. 2, p. 72-8, ISSN: 0174-304X.
    Active substance: BIOTIN
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    Document reference: 22595
    Study title: Grover-W-D, Auerbach-V-H, Patel-M-S. Biochemical studies and therapy in subacute necrotizing encephalomyelopathy (Leigh's syndrome). The Journal of pediatrics, {J-Pediatr}, Jul 1972, vol. 81, no. 1, p. 39-44, ISSN: 0022-3476.Grover-W-D, Auerbach-V-H, Patel-M-S. Biochemical studies and therapy in subacute necrotizing encephalomyelopathy (Leigh's syndrome). The Journal of pediatrics, {J-Pediatr}, Jul 1972, vol. 81, no. 1, p. 39-44, ISSN: 0022-3476.
    Active substance: BIOTIN
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    Document reference: 22671
    Study title: Petrocini-S, Debernardi-P. La biotina nel trattamento dell'eritrodermia desquamativa e della dermatite seborroide; risultati clinici. Il Lattante, {Lattante}, Jun 1954, vol. 25, no. 6, p. 360-6, ISSN: 0023-8864.Petrocini-S, Debernardi-P. La biotina nel trattamento dell'eritrodermia desquamativa e della dermatite seborroide; risultati clinici. Il Lattante, {Lattante}, Jun 1954, vol. 25, no. 6, p. 360-6, ISSN: 0023-8864.
    Active substance: BIOTIN
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    Document reference: 22590
    Study title: Rahman-S, Standing-S, Dalton-R-N, Pike-M-G. Institute of Child Health, London, UK. Late presentation of biotinidase deficiency with acute visual loss and gait disturbance. Developmental medicine and child neurology, {Dev-Med-Child-Neurol}, Dec 1997, vol. 39, no. 12, p. 830-1, ISSN: 0012-1622.Rahman-S, Standing-S, Dalton-R-N, Pike-M-G. Institute of Child Health, London, UK. Late presentation of biotinidase deficiency with acute visual loss and gait disturbance. Developmental medicine and child neurology, {Dev-Med-Child-Neurol}, Dec 1997, vol. 39, no. 12, p. 830-1, ISSN: 0012-1622.
    Active substance: BIOTIN
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    Document reference: 22616
    Study title: Sander-J-E, Malamud-N, Cowan-M-J, Packman-S, Amman-A-J, Wara-D-W. Intermittent ataxia and immunodeficiency with multiple carboxylase deficiencies: a biotin-responsive disorder. Annals of neurology, {Ann-Neurol}, Nov 1980, vol. 8, no. 5, p. 544-7, ISSN: 0364-5134.Sander-J-E, Malamud-N, Cowan-M-J, Packman-S, Amman-A-J, Wara-D-W. Intermittent ataxia and immunodeficiency with multiple carboxylase deficiencies: a biotin-responsive disorder. Annals of neurology, {Ann-Neurol}, Nov 1980, vol. 8, no. 5, p. 544-7, ISSN: 0364-5134.
    Active substance: BIOTIN
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    Document reference: 22664
    Study title: Schuermann-M, Engelbrecht-V, Lohmeier-K, Lenard-H-G, Wendel-U, Gaertner-J. Department of Paediatrics, Heinrich-Heine-University, Duesseldorf, Germany. Cerebral metabolic changes in biotinidase deficiency. Journal of inherited metabolic disease, {J-Inherit-Metab-Dis}, Nov 1997, vol. 20, no. 6, p. 755-60, ISSN: 0141-8955.Schuermann-M, Engelbrecht-V, Lohmeier-K, Lenard-H-G, Wendel-U, Gaertner-J. Department of Paediatrics, Heinrich-Heine-University, Duesseldorf, Germany. Cerebral metabolic changes in biotinidase deficiency. Journal of inherited metabolic disease, {J-Inherit-Metab-Dis}, Nov 1997, vol. 20, no. 6, p. 755-60, ISSN: 0141-8955.
    Active substance: BIOTIN
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    Document reference: 22617
    Study title: Shelley-W-B, Shelley-E-D. Uncombable hair syndrome: observations on response to biotin and occurrence in siblings with ectodermal dysplasia. Journal of the American Academy of Dermatology, {J-Am-Acad-Dermatol}, Jul 1985, vol. 13, no. 1, p. 97-102, ISSN: 0190-9622. Shelley-W-B, Shelley-E-D. Uncombable hair syndrome: observations on response to biotin and occurrence in siblings with ectodermal dysplasia. Journal of the American Academy of Dermatology, {J-Am-Acad-Dermatol}, Jul 1985, vol. 13, no. 1, p. 97-102, ISSN: 0190-9622.
    Active substance: BIOTIN
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    Document reference: 22572
    Study title: Sweetman-L. Two forms of biotin-responsive multiple carboxylase deficiency. Journal of inherited metabolic disease, {J-Inherit-Metab-Dis}, 1981, vol. 4, no. 2, p. 53-4, ISSN: 0141-8955.Sweetman-L. Two forms of biotin-responsive multiple carboxylase deficiency. Journal of inherited metabolic disease, {J-Inherit-Metab-Dis}, 1981, vol. 4, no. 2, p. 53-4, ISSN: 0141-8955.
    Active substance: BIOTIN
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    Document reference: 22660
    Study title: Thuy-L-P, Zielinska-B, Zammarchi-E, Pavari-E, Vierucci-A, Sweetman-F, Sweetman-L, Nyhan-W-L. Multiple carboxylase deficiency due to deficiency of biotinidase. Journal of neurogenetics, {J-Neurogenet}, Nov 1986, vol. 3, no. 6, p. 357-63, ISSN: 0167-7063.Thuy-L-P, Zielinska-B, Zammarchi-E, Pavari-E, Vierucci-A, Sweetman-F, Sweetman-L, Nyhan-W-L. Multiple carboxylase deficiency due to deficiency of biotinidase. Journal of neurogenetics, {J-Neurogenet}, Nov 1986, vol. 3, no. 6, p. 357-63, ISSN: 0167-7063.
    Active substance: BIOTIN
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    Document reference: 22640
    Study title: Velazquez-A, Teran-M, Baez-A, Gutierrez-J, Rodriguez-R. Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas UNAM, Mexico. Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. The American journal of clinical nutrition, {Am-J-Clin-Nutr}, Feb 1995, vol. 61, no. 2, p. 385-91, ISSN: 0002-9165.Velazquez-A, Teran-M, Baez-A, Gutierrez-J, Rodriguez-R. Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas UNAM, Mexico. Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. The American journal of clinical nutrition, {Am-J-Clin-Nutr}, Feb 1995, vol. 61, no. 2, p. 385-91, ISSN: 0002-9165.
    Active substance: BIOTIN
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    Document reference: 22619
    Study title: Williams-M-L, Packman-S, Cowan-M-J. Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency. Journal of the American Academy of Dermatology, {J-Am-Acad-Dermatol}, Jul 1983, vol. 9, no. 1, p. 97-103, ISSN: 0190-9622.Williams-M-L, Packman-S, Cowan-M-J. Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency. Journal of the American Academy of Dermatology, {J-Am-Acad-Dermatol}, Jul 1983, vol. 9, no. 1, p. 97-103, ISSN: 0190-9622.
    Active substance: BIOTIN
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    Document reference: 22575
    Study title: Mock-D-M, Baswell-D-L, Baker-H, Holman-R-T, Sweetman-L. Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment. Annals of the New York Academy of Sciences, {Ann-N-Y-Acad-Sci}, 1985, vol. 447, p. 314-34, ISSN: 0077-8923. Mock-D-M, Baswell-D-L, Baker-H, Holman-R-T, Sweetman-L. Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment. Annals of the New York Academy of Sciences, {Ann-N-Y-Acad-Sci}, 1985, vol. 447, p. 314-34, ISSN: 0077-8923.
    Active substance: BIOTIN
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    Document reference: 22643
    Study title: J.A.R. Calderon: Uso de Pantogar en la terapia contra la caida difusa del cabello y danos estructurales del mismo, 2003
    Active substance: VITAMIN COMBINATIONS
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    Document reference: 39401
    Study title: Bates BYC, Evans PH, Sonko BJ, et al. Biochemical indices and neuromuscular function tests in rural Gambian schoolchildren given a riboflavin, or multivitamin plus iron, supplement. British J of Nutr, 1994:72;601-610.Bates BYC, Evans PH, Sonko BJ, et al. Biochemical indices and neuromuscular function tests in rural Gambian schoolchildren given a riboflavin, or multivitamin plus iron, supplement. British J of Nutr, 1994:72;601-610.
    Active substance: VITAMINS
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    Document reference: 45571
    Study title: Benton D, Roberts G. Effect of vitamin and mineral supplementation on intelligence on a sample of schoolchildren. Lancet, 1988:1;140-3.Benton D, Roberts G. Effect of vitamin and mineral supplementation on intelligence on a sample of schoolchildren. Lancet, 1988:1;140-3.
    Active substance: VITAMINS
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    Document reference: 45576
    Study title: Effect of long-acting garlic tablets "allicor" on the incidence of acute respiratory viral infections in children. Andrianova IV, Sobenin IA, Sereda EV, Borodina LI, Studenikin MI. Ter Arkh. 2003;75(3):53-6.Effect of long-acting garlic tablets "allicor" on the incidence of acute respiratory viral infections in children. Andrianova IV, Sobenin IA, Sereda EV, Borodina LI, Studenikin MI. Ter Arkh. 2003;75(3):53-6.
    Active substance: VITAMINS
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    Document reference: 45569
    Study title: Garlic extract therapy in children with hypercholesterolemia. McCrindle BW, Helden E, Conner WT. Arch Pediatr Adolesc Med. 1998 Nov;152(11):1089-94. Garlic extract therapy in children with hypercholesterolemia. McCrindle BW, Helden E, Conner WT. Arch Pediatr Adolesc Med. 1998 Nov;152(11):1089-94.
    Active substance: VITAMINS
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    Document reference: 45570
    Study title: Geltman PL, Meyers AF, Mehta SD, et al. Daily multivitamins with iron to prevent anemia in high-risk infants: A randomized clinical trial. Pediatrics, 2004:114;86-93.Geltman PL, Meyers AF, Mehta SD, et al. Daily multivitamins with iron to prevent anemia in high-risk infants: A randomized clinical trial. Pediatrics, 2004:114;86-93.
    Active substance: VITAMINS
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    Document reference: 45572
    Study title: Immunological and clinical study on therapeutic efficacy of inosine pranobex, Gołebiowska-Wawrzyniak M, Markiewicz K, Kozar A, Derentowicz P, Czerwińska-Kartowicz I, Jastrzebska-Janas K, Wacławek J, Wawrzyniak ZM, Siwińska-Gołebiowska H. Pol Merkur Lekarski. 2005 Sep;19(111):379-82.Immunological and clinical study on therapeutic efficacy of inosine pranobex, Gołebiowska-Wawrzyniak M, Markiewicz K, Kozar A, Derentowicz P, Czerwińska-Kartowicz I, Jastrzebska-Janas K, Wacławek J, Wawrzyniak ZM, Siwińska-Gołebiowska H. Pol Merkur Lekarski. 2005 Sep;19(111):379-82.
    Active substance: VITAMINS
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    Document reference: 45568
    Study title: Linday LA, Tapia-Mendoza J, Shindledecker, RD, et al. Effect of daily cod liver oil and a mutlivtamin-mineral supplement with selenium on upper respiratory tract pediatric visits by young, inner-city, Latino children: randomized pediatric sites. Ann Otol Rhinol Laryngol, 2004:113;891-901.Linday LA, Tapia-Mendoza J, Shindledecker, RD, et al. Effect of daily cod liver oil and a mutlivtamin-mineral supplement with selenium on upper respiratory tract pediatric visits by young, inner-city, Latino children: randomized pediatric sites. Ann Otol Rhinol Laryngol, 2004:113;891-901.
    Active substance: VITAMINS
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    Document reference: 45575
    Study title: Ozkan B, Bereket A, Turan S. Addition of orlistat to conventional treatment in adolescents with severe obesity. Eur J Pediatr, 2004:163:738-741.Ozkan B, Bereket A, Turan S. Addition of orlistat to conventional treatment in adolescents with severe obesity. Eur J Pediatr, 2004:163:738-741.
    Active substance: VITAMINS
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    Document reference: 45573
    Study title: Suntaree, RE. Effects of multivitamin and folic acid supplementation in malnourished children. J Med Assoc Thailand, 2003:86;S537-42.Suntaree, RE. Effects of multivitamin and folic acid supplementation in malnourished children. J Med Assoc Thailand, 2003:86;S537-42.
    Active substance: VITAMINS
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    Document reference: 45574
    Study title: The use of multivitamin-preparations in paediatricsThe use of multivitamin-preparations in paediatrics
    Active substance: VITAMINS
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    Document reference: 45566
    Study title: Wessely P. Klinischer Erfahrungsbericht. 1985. AKH Wien, Neurologische Univ-Klinik Wessely P. Klinischer Erfahrungsbericht. 1985. AKH Wien, Neurologische Univ-Klinik
    Active substance: VITAMINS
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    Document reference: 45567
    Study title: A 12-Month Study to Assess the Safety and Efficacy of Meridia® (sibutramine hydrochloride monohydrate) 10 and 15 mg in Obese Adolescents
    Active substance: SIBUTRAMINE
    Study summary document link (including results): Sibutramine-SB238.pdf
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    Document reference: 47621
    Study title: A randomised, placebo controlled, doubly blind study of the effect of sibutramine on the treatment of obese adolescents with a recommended diet and exercise plan followed by a sibutramine-free period (SB116)
    Active substance: SIBUTRAMINE
    Study summary document link (including results): Sibutramine-SB116.pdf
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    Document reference: 47620
    Study title: An open-label, single dose, pharmacokinetic study of sibutramine and its metabolites in obese adolescents.
    Active substance: SIBUTRAMINE
    Study summary document link (including results): Sibutramine-SB240.pdf
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    Document reference: 47622
    Study title: Impact Sibutramine Therapy in Children with Hypothalamic Obesity or Obesity with Aggravating Syndromes
    Active substance: SIBUTRAMINE
    Study summary document link (including results): sibutramine-danielsson.xls
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    Document reference: 48136
    Study title: Use of Sibutramine in Obese Mexican Adolescents: A 6-Month, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial
    Active substance: SIBUTRAMINE
    Study summary document link (including results): sibutramine-garciamorales.xls
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    Document reference: 48137
    Study title: A 30-Week, Forced-titration and Randomised, Crossover, Multicentre, Multinational Trial to Evaluate the Efficacy and Safety of rosuvastatin and Atorvastatin in Subjects with Homozygous Familial Hypercholesterolaemia (4522IL/0054): Full Report of the First 18 Weeks (forced-titration) and Last 12 Weeks of Treatment (crossover period) for Efficacy and for Safety
    Active substance: ROSUVASTATIN CALCIUM
    Study summary document link (including results): Study 4522IL0054_CSR Synopsis.pdf
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    Document reference: 47886
    Study title: Pharmacokinetics of Rosuvastatin in Children and Adolescents with Heterozygous Familial Hypercholesterolemia (4522IL/0086)
    Active substance: ROSUVASTATIN CALCIUM
    Study summary document link (including results): Study 4522IL0086_CSR Synopsis.pdf
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    Document reference: 47885
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