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Clinical trials for Microbubbles

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    18 result(s) found for: Microbubbles. Displaying page 1 of 1.
    EudraCT Number: 2019-001736-57 Sponsor Protocol Number: 20190416MH Start Date*: 2019-06-24
    Sponsor Name:St Olavs Hospital
    Full Title: ULTRASOUND-ENHANCED UPTAKE OF CHEMOTHERAPY IN PATIENTS WITH INOPERABLE PANCREATIC DUCTAL ADENOCARCINOMA
    Medical condition: Pancreatic cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10033604 Pancreatic cancer LLT
    20.0 100000004864 10033606 Pancreatic cancer non-resectable LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-000988-25 Sponsor Protocol Number: version4 Start Date*: 2012-04-27
    Sponsor Name:Gateshead Health NHS Trust Research & Development
    Full Title: To determine the feasibility of using Microbubble technology to detect sentinel nodes in vulvar cancer.
    Medical condition: Early stage vulvar cancer with no clinial or radiological evidence of lymph node metastases
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-000393-20 Sponsor Protocol Number: AX-CES1.2020 Start Date*: 2020-10-23
    Sponsor Name:DIP. MEDICINA DEI SISTEMI UNIVERSITà DEGLI STUDI DI ROMA TOR VERGATA
    Full Title: USE OF SULFUR HEXAFLUORIDE MICROBUBBLES IN INTRAOPERATIVE SURGICAL EVALUATION OF AXILLARY LYMPH NODES IN LOCO-REGIONAL ANESTHESIA BREAST SURGERY: COMPARISON WITH THE TRADITIONAL METHODICAL. PRELIMI...
    Medical condition: Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004848 10072873 Sentinel lymph node mapping LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-005471-15 Sponsor Protocol Number: NZHD01 Start Date*: 2006-03-27
    Sponsor Name:University of Heidelberg
    Full Title: Real-time contrast-enhanced sonography of renal transplant recipients accurately predicts chronic allograft nephropathy
    Medical condition: Chronic allograft nephropathy (CAN) represents the main cause of renal allograft loss after 1 yr of transplantation. The trial shall find a way for early diagnostics.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-000630-35 Sponsor Protocol Number: Start Date*: 2013-10-07
    Sponsor Name:Alder Hey Children's NHS Foundation Trust
    Full Title: Pilot study on use of Sulphur hexafluoride Microbubbles (SonoVue®) as a Magnetic Resonance Imaging contrast agent in the imaging of brain tumours.
    Medical condition: Patients undergoing pre-operative/follow up MRI investigation for a known enhancing brain tumour
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2012-000512-29 Sponsor Protocol Number: IIBSP-SPM-2011-63 Start Date*: 2012-06-18
    Sponsor Name:Institut de Recerca Hospital Sant Pau
    Full Title: Sonothrombolysis potentiated by microbubbles as a novel treatment of acute ischemic stroke: a prospective randomized pilot study
    Medical condition: Acute ischemic brain stroke
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-001935-23 Sponsor Protocol Number: NZHD02 Start Date*: 2006-10-17
    Sponsor Name:University of Heidelberg
    Full Title: Real-time contrast-enhanced sonography of renal transplant recipients accurately predicts vascular allograft nephropathy
    Medical condition: Vascular allograft nephropathy represents the main cause of renal allograft loss after 1 yr of transplantation. The trial shall find a way for early diagnostics.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-002514-23 Sponsor Protocol Number: Car20130917 Start Date*: 2015-01-07
    Sponsor Name:VU Medical Center
    Full Title: Reduction Of Microvascular Injury Utilizing Sonolysis
    Medical condition: Myocardial infarction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-000819-67 Sponsor Protocol Number: MTW_2020_KC01 Start Date*: 2020-07-28
    Sponsor Name:Maidstone and Tunbridge Wells NHS Trust
    Full Title: SENTINUS: Technical feasibility and diagnostic accuracy of intradermal microbubbles and contrast enhanced ultrasound to identify sentinel lymph node metastases in breast cancer patients following t...
    Medical condition: Breast Cancer - Using SonoVue injected intradermally into the breast and contrast enhanced ultrasound to see if the cancer has spread via lymphatic channels to sentinel lymph nodes in the axilla.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-000159-15 Sponsor Protocol Number: PRTK15-TL/SONCHIMIO Start Date*: 2018-01-12
    Sponsor Name:CHRU TOURS
    Full Title: Targeted delivery of chemotherapy with ultrasound and microbubbles
    Medical condition: Colo-Rectal Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10052362 Metastatic colorectal cancer LLT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10061451 Colorectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-002554-30 Sponsor Protocol Number: MICROBUB-2011-01 Start Date*: 2012-06-26
    Sponsor Name:Fundación Renal Jaume Arnó
    Full Title: Effect of Paricalcitol on blood vessels: an investigation over pleotropic analogues of vitamin-D.
    Medical condition: Enfermedad Renal crónica, estadío VD
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-000333-40 Sponsor Protocol Number: 11-534 Start Date*: 2012-07-30
    Sponsor Name:University Medical Center Utrecht
    Full Title: Towards plannable breast surgery: diagnostic accuracy of microbubble enhanced Iodine-125 seed localization of the sentinel lymph node (MIB study)
    Medical condition: Patient with breast cancer with an indication for sentinel lymph node biopsy
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2022-001710-19 Sponsor Protocol Number: LUMINALSONAZOID001 Start Date*: 2022-11-01
    Sponsor Name:Medical department, Haukeland University Hospital
    Full Title: Sonographic diagnostics with oral contrast for Crohns. A novel method for detecting Crohns disease using sonographic intraluminal contrast.
    Medical condition: Crohns disease in the terminal ileum
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005288-33 Sponsor Protocol Number: EMI111784 Start Date*: 2008-12-18
    Sponsor Name:GlaxoSmithKline Research & Development, LtdD
    Full Title: Methodology Study to develop Sinerem enhanced 3T MR Imaging of Atherosclerotic Plaques within the Carotid Arteries, and to compare Sinerem MRI to contrast enhanced ultrasound
    Medical condition: Atherosclerotic plaque within the carotid artery.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10051615 Atherosclerotic cardiovascular disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-024528-12 Sponsor Protocol Number: HGRWLBKULT1 Start Date*: 2011-02-14
    Sponsor Name:Henning Glerup
    Full Title: Kontrast UltraLydsskanning af Tyndtarmen hos patienter med Crohns sygdom – et pilotstudie (KULT)
    Medical condition: Morbus Crohn disease with signs of activity in the small bowel.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10011401 Crohn's disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-005886-19 Sponsor Protocol Number: HGKKRWPHD2 Start Date*: 2012-07-31
    Sponsor Name:Gastroenterology MIDT
    Full Title: Correlation between intestinal blOod flow assessed by magNetic resonance imaging and ulTRASound Techniques (CONTRAST)
    Medical condition: Crohns Disease with active disease
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022891 - Investigations 10059696 Scan with contrast PT
    14.1 10017947 - Gastrointestinal disorders 10011403 Crohn's disease aggravated LLT
    14.1 10022891 - Investigations 10028049 MRI LLT
    14.1 10022891 - Investigations 10045434 Ultrasound scan PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000110-19 Sponsor Protocol Number: P060406 Start Date*: 2012-01-10
    Sponsor Name:Assistance Publique – Hôpitaux de Paris (AP-HP)
    Full Title: Closure of patent foramen ovale or anticoagulants versus antiplatelet therapy to prevent stroke recurrence
    Medical condition: The study compares different strategies for secondary stroke (or retinal ischaemia) prevention in patients with patent foramen ovale. The three treatment arms comprise: 1. Endovascular patent f...
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10036654 Prevention LLT
    19.0 100000004850 10016982 Foramen ovale patent LLT
    19.0 100000004852 10042244 Stroke LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-005846-36 Sponsor Protocol Number: HGKKRWPHD Start Date*: 2012-07-31
    Sponsor Name:Gastroenterology MIDT
    Full Title: Safe evaluation of obstructive crohns disease using bloodflow Time-intensity curves and Elastography correlated to Neutrocytes and collagen counts and biomechanical properties Obtained in Stenotic ...
    Medical condition: Crohns Disease undergoing elective surgery for intestinal stenosis.
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10058829 Elective surgery PT
    14.1 10022891 - Investigations 10059696 Scan with contrast PT
    14.1 10017947 - Gastrointestinal disorders 10011401 Crohn's disease PT
    14.1 10022891 - Investigations 10028049 MRI LLT
    14.1 10022891 - Investigations 10045434 Ultrasound scan PT
    14.1 10017947 - Gastrointestinal disorders 10022699 Intestinal stenosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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