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Clinical trials for Phenylephrine

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    69 result(s) found for: Phenylephrine. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2009-013293-41 Sponsor Protocol Number: 08/0182 Start Date*: 2011-03-21
    Sponsor Name:Joint UCLH/UCH Biomedical Research Unit
    Full Title: Randomised, double blind, phase IV study to compare the incidence of ECG changes during elective caesarean section under spinal anaesthesia when using phenylephrine or ephedrine infusion to maintai...
    Medical condition: uncomplicated term pregnancy. Patient undergoing elective cesarean delivery. Ephedrine and phenylephrine are vasopressors used to maintain maternal blood pressure close to normal values during spin...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-004858-25 Sponsor Protocol Number: RF01 Start Date*: 2007-02-16
    Sponsor Name:Royal Free Hampstead NHS Trust
    Full Title: Study to compare maternal cardiovascular stability with different phenylephrine dosing regimens used to maintain baseline systolic blood pressure following a spinal anaesthetic for elective caesare...
    Medical condition: We are studying healthy pregnant women undergoing planned caesarean section under spinal anaesthesia. We are investigating ways of reducing hypotension due to spinal anaesthesia by comparing 3 diff...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-001839-13 Sponsor Protocol Number: AGO/2016/006 Start Date*: 2016-06-07
    Sponsor Name:Ghent University Hospital
    Full Title: Influence of a bolus administration of ephedrine and phenylephrine on spinal oxygen saturation, measured with NIRS.
    Medical condition: Hypotension during surgery Paraplegia and/or paraparesis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2020-000573-25 Sponsor Protocol Number: 1.1 Start Date*: 2020-03-20
    Sponsor Name:Aarhus University Hospital
    Full Title: Evaluation of patients after cardiac surgery: Novel ultrasound parameters for quantification of renal perfusion & analysis of phenylephrines’ effect on invasive haemodynamics and echocardiographic ...
    Medical condition: Hypotension
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2018-003687-31 Sponsor Protocol Number: AGO/2018/005 Start Date*: 2019-01-31
    Sponsor Name:Ghent University Hospital
    Full Title: Influence of continuous administration of phenylephrine versus dobutamine on spinal oxygen saturation, measured with near-infrared spectroscopy (NIRS).
    Medical condition: spinal vasculature spinal oxygen saturation muscle oxygen saturation cerebral oxygen saturation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2018-002339-23 Sponsor Protocol Number: MydriasisbeiMydrane Start Date*: 2019-10-24
    Sponsor Name:Medical University Graz, Department of Ophtalmology
    Full Title: Prospective intraindividual comparison of the mydriasis of a standardized intracameral anaesthetics with the topical preoperative drop application in the uncomplicated cataract surgery
    Medical condition: patients who need a cataract surgery in both eyes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-001023-32 Sponsor Protocol Number: RACE_01 Start Date*: 2022-09-14
    Sponsor Name:Medical University of Vienna
    Full Title: The effect of epinephrine, norepinephrine and phenylephrine on intraoperative hemodynamic performance - a prospective double-blinded, randomized clinical trial
    Medical condition: Patients > 45 years of age at-risk for cardiovascular complications undergoing moderate- to high-risk major open abdominal surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-013543-11 Sponsor Protocol Number: 2009057 Start Date*: 2009-10-19
    Sponsor Name:James Cook University Hospital
    Full Title: A comparison of nausea with two routine ways of managing low blood pressure after delivery of the baby during spinal anaesthesia for Caesarean section.
    Medical condition: We are investigating nausea associated with hypotension caused by spinal anaesthesia in healthy women undergoing elective Caesarean section. NICE recommend phenylephrine in this population. The aim...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-004309-27 Sponsor Protocol Number: P04579 Start Date*: 2005-12-28
    Sponsor Name:Schering Plough Research Institute
    Full Title: Cross-Over Study of the Decongestant Effect of Phenylephrine Compared With Placebo and Pseudoephedrine as Active Control in SAR Subjects Exposed to Pollen in the Vienna Challenge Chamber
    Medical condition: Seasonal Allergic Rhinitis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2019-000965-19 Sponsor Protocol Number: 2019/374 Start Date*: 2019-08-26
    Sponsor Name:Helse Fonna
    Full Title: “Haemodynamic stability during induction of general anesthesia with propofol and remifentanil: A randomized, controlled, double-blind study comparing equipotent prophylactic doses of ephedrine, phe...
    Medical condition: Ephedrine, phenylephrine and norepinephrine are vasopressors used during anesthesia to treat hypotension. These agents raise blood pressure, but may have different effects on circulation as measure...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003064-36 Sponsor Protocol Number: DEF_Version_1.2 Start Date*: 2015-11-10
    Sponsor Name:Vienna Institute for Research in Ocular Surgery
    Full Title: Impact of selective alpha 1A receptor antagonists on the pupil size after instillation of tropicamide 0.5% and phenylephrine 10%
    Medical condition: Impact of selective alpha 1A receptor antagonists on the pupil size after instillation of tropicamide 0.5% and phenylephrine 10%
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-002385-23 Sponsor Protocol Number: AFT-MXCF-03 Start Date*: 2015-11-10
    Sponsor Name:AFT Pharmaceuticals Ltd
    Full Title: A phase 3 randomised, double blind, multiple dose, parallel group efficacy study of different doses of phenylephrine hydrochloride combined with paracetamol and/or ibuprofen in participants with na...
    Medical condition: nasal congestion
    Disease: Version SOC Term Classification Code Term Level
    18.0 10038738 - Respiratory, thoracic and mediastinal disorders 10028735 Nasal congestion PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-006103-35 Sponsor Protocol Number: SJ-271 Start Date*: 2012-01-30
    Sponsor Name:Næstved hospital
    Full Title: The Oxygenation of the Brain DUring elective Caesarean section. A comparison of ephedrine versus phenylephrine
    Medical condition: Elective ceasarean section
    Disease: Version SOC Term Classification Code Term Level
    14.1 10036585 - Pregnancy, puerperium and perinatal conditions 10036565 Pregnancy normal LLT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-005617-13 Sponsor Protocol Number: MVDV122013 Start Date*: 2014-05-27
    Sponsor Name:University Hospitals Leuven
    Full Title: Determination of the equivalent dose of phenylephrine and Akrinor in the prevention of post-spinal hypotension during Cesarean section.
    Medical condition: post-spinal hypotension
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10007532 Cardiac complications of anesthesia or other sedation in labor and delivery LLT
    Population Age: Adults Gender: Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2004-002734-19 Sponsor Protocol Number: 2004066 Start Date*: 2005-08-23
    Sponsor Name:South Tees Acute Hospitals NHS Trust
    Full Title: Do the drugs that are normally used to treat low blood pressure during Caesarean section affect spread of spinal anaesthesia?
    Medical condition: We plan to study women having elective, low-risk, Caesarean sections under spinal anaesthesia. Hypotension is very frequent with spinal anaesthesia in this patient population and it usually require...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-003182-34 Sponsor Protocol Number: 2018-10 Start Date*: 2018-10-18
    Sponsor Name:CHR d'ORLEANS
    Full Title: Randomized, double-blind, controlled clinical trial for comparison of continuous phenylephrine versus norepinephrine infusion for maintenance of hemodynamic stability during cesarean section under...
    Medical condition: hypotension during caesarean section under spinal anesthesia
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-003470-88 Sponsor Protocol Number: 11-195 Start Date*: 2012-07-30
    Sponsor Name:University Medical Center Utrecht, The Netherlands
    Full Title: Phenylephrine versus EPhedrine on cerebral Perfusion during carotid EndarteRectomy: PEPPER study
    Medical condition: Hypotension during carotid endarterectomy
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10062300 Procedural hypotension PT
    14.1 10042613 - Surgical and medical procedures 10007692 Carotid endarterectomy PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-000292-33 Sponsor Protocol Number: HGC_SAR_1_13 Start Date*: 2013-11-07
    Sponsor Name:Laura Sararols Ramsay
    Full Title: Comparative study of the mydriatic effect of Mydriasert vs the use of topical instillation of phenylephrine (10%) and tropicamide (1%) before catarcat surgery.
    Medical condition: Cataract surgery
    Disease: Version SOC Term Classification Code Term Level
    16.0 100000004853 10039960 Senile cataract LLT
    16.0 10042613 - Surgical and medical procedures 10063797 Cataract operation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2012-005576-33 Sponsor Protocol Number: LT2380-PII-09/12 Start Date*: 2013-09-03
    Sponsor Name:Laboratoires Théa
    Full Title: Efficacy and safety assessment of intracameral T2380 (Fixed combination of lidocaïne, phenylephrine and tropicamide) to obtain mydriasis in patients with small pupils for cataract surgery by phacoe...
    Medical condition: The primary aim of this study is to evaluate mydriasis obtained with T2380 (Fixed combination of lidocaïne, phenylephrine and tropicamide) in patients with small pupils
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-003926-11 Sponsor Protocol Number: MVDV 07/2007 Start Date*: 2007-10-03
    Sponsor Name:University Hospitals Leuven
    Full Title: Low dose of ephedrine versus phenylephrine in the prevention of arterial hypotension after low dosed CSE for elective C-section : is there a difference in umbilical blood gas values ?
    Medical condition: combined spinal-epidural analgesia during C-section
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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