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Clinical trials for Toothpaste

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44364   clinical trials with a EudraCT protocol, of which   7388   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    10 result(s) found for: Toothpaste. Displaying page 1 of 1.
    EudraCT Number: 2020-000213-33 Sponsor Protocol Number: 14012020 Start Date*: 2020-04-21
    Sponsor Name:Department of Dentistry and Oral Health
    Full Title: Fluoride in saliva during and after use of high-fluoride toothpaste
    Medical condition: Not applicable. A physiological phenomena is explored.
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004848 10053349 Pharmacokinetic study LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2009-015914-23 Sponsor Protocol Number: T3450515 Start Date*: 2009-12-24
    Sponsor Name:GlaxoSmithKline Consumer Healthcare (GSKCH)
    Full Title: Clinical efficacy of an experimental toothpaste
    Medical condition: Gingivitis
    Disease: Version SOC Term Classification Code Term Level
    12.0 10018292 Gingivitis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2017-002402-13 Sponsor Protocol Number: R04684 Start Date*: 2018-02-02
    Sponsor Name:Manchester University NHS Foundation Trust
    Full Title: A Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose FLuoride toothpaste in preventing and treating dEntal Caries in high-risk older adulTs (REFLECT...
    Medical condition: Dental caries in high-risk older adults
    Disease: Version SOC Term Classification Code Term Level
    20.0 10017947 - Gastrointestinal disorders 10012318 Dental caries PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-002248-34 Sponsor Protocol Number: FInCH Start Date*: 2018-02-20
    Sponsor Name:King's College London
    Full Title: FInCH Study: A randomised feasibility study comparing fluoride interventions to prevent dental decay in older people in care homes.
    Medical condition: Prevention of dental decay in older people in care homes
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10011947 Decay dental LLT
    20.1 100000004856 10048297 Dental decay LLT
    20.1 100000004856 10044027 Tooth decay LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2013-002418-11 Sponsor Protocol Number: RH01913 Start Date*: 2013-08-12
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A study to evaluate the effect of a 67% Sodium Bicarbonate containing toothpaste on Chlorhexidine Digluconate tooth staining
    Medical condition: Tooth discolouration (a labelled undesirable effect of Corsodyl 0.2% mouthwash)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10044032 Tooth discolouration PT
    14.1 10021881 - Infections and infestations 10018292 Gingivitis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: Removed from public view
    EudraCT Number: 2008-002982-30 Sponsor Protocol Number: AGO/2008/004 Start Date*: 2008-10-09
    Sponsor Name:University Hospital Ghent
    Full Title: A Prospective, randomized, clinical study on the effects of CPP-ACP paste on plaque, gingivitis and initial caries lesion development in orthodontic patients - part 2
    Medical condition: Plaque and the initial development of caries and gingivitis in orthodontic patients.
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002366-38 Sponsor Protocol Number: P305 R-EF02 Start Date*: 2004-11-16
    Sponsor Name:GABA GmbH
    Full Title: Fluoride uptake and remineralisation of incipient carious lesions following the application of fluoride fluids with different fluoride concentrations
    Medical condition: caries lesions
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-008594-58 Sponsor Protocol Number: GASAS-0809X Start Date*: 2009-07-24
    Sponsor Name:GABA International AG
    Full Title: In situ mineral change and fluoride retention of sound and demineralized enamel in high cariogenic milieus following the single application of a 1.25%- fluoride or a placebo gel.
    Medical condition: Remineralization, fluoride uptake, and lesion depth of sound and demineralized, plaque-covered enamel after the application of elmex gel will be tested in situ in comparison to a placebo gel.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-010725-39 Sponsor Protocol Number: 56493 Start Date*: 2009-07-23
    Sponsor Name:The University of Manchester [...]
    1. The University of Manchester
    2. Belfast Health and Social Care Trust
    Full Title: A randomised controlled trial to measure the effects and costs of a dental caries prevention regime for young children attending primary care dental services
    Medical condition: Dental Caries
    Disease: Version SOC Term Classification Code Term Level
    14.1 10017947 - Gastrointestinal disorders 10012318 Dental caries PT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-000990-39 Sponsor Protocol Number: V00109 DI 301 Start Date*: 2008-05-22
    Sponsor Name:PIERRE FABRE MEDICAMENT
    Full Title: Reduction of the gingival inflammation by V0109 DI. Randomised, parallel groups, double blind study, V0109 DI versus placebo, in patients presenting gingivitis.
    Medical condition: Reduction of the gingival inflammation by V0109 DI.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012325 Dental and periodontal infections and inflammations HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: EE (Completed) LV (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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