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Clinical trials for Vascular endothelium

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    32 result(s) found for: Vascular endothelium. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2009-011723-31 Sponsor Protocol Number: VPA-study Start Date*: 2009-12-09
    Sponsor Name:Västra Götalandsregionen
    Full Title: Effects of valproic acid on fibrinolysis in man
    Medical condition: This is a healthy volunteer trial. The intended indication for the product is to investigate if upregulation of the tPA-gene by valproic acid results in increased tPA-release from endothelium in f...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10016603 Fibrinolysis LLT
    Population Age: Adults Gender: Male
    Trial protocol: SE (Restarted)
    Trial results: (No results available)
    EudraCT Number: 2008-005759-21 Sponsor Protocol Number: Start Date*: 2011-04-21
    Sponsor Name:University of Oxford
    Full Title: Can atorvastatin improve vascular function in women with a history preeclampsia? A Randomised, double-blinded, placebo-controlled crossover trial of atorvastatin in women with a history of preeclam...
    Medical condition: Cardiovascular disease in women with a history of preeclampsia
    Disease: Version SOC Term Classification Code Term Level
    13.1 10047065 - Vascular disorders 10047063 Vascular disorder peripheral LLT
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-005227-42 Sponsor Protocol Number: PM1108357 Start Date*: 2007-08-30
    Sponsor Name:GlaxoSmithKline Research & Development Ltd
    Full Title: A double-blind, placebo-controlled, parallel study to evaluate the effects of GW-856553 on endothelial function/ vascular compliance in subjects with dyslipidaemia.
    Medical condition: GW-856553 is under development as a potential anti-atherosclerosis agent for reduction of major cardiovascular events in high risk patient populations
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-004529-57 Sponsor Protocol Number: 06/AM/108 Start Date*: 2008-09-08
    Sponsor Name:Greenpark Healthcare Trust
    Full Title: Vascular Pleiotrophic Effects of Bisphosphonates in Post Menopausal Women with Osteoporosis: Cellular Mechanisms and Functional Consequences
    Medical condition: osteoporosis cardiovascular disease
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-016600-23 Sponsor Protocol Number: 05102009 Start Date*: 2010-07-09
    Sponsor Name:Hull and East Yorkshire Hospitals NHS Trust
    Full Title: A double blind, randomised, placebo controlled trial to study the clinical effectiveness of Angiotensin Converting Enzyme (ACE) inhibitors, ramipril,in patients with intermittent claudication
    Medical condition: Intermittent Claudication
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-017537-21 Sponsor Protocol Number: PHT/2009/36 Start Date*: 2010-03-02
    Sponsor Name:Portsmouth Hospitals NHS Trust
    Full Title: Oral thiamine (Vitamin B1) supplementation in subjects with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled crossover trial assessing biophysical markers of endothelial fun...
    Medical condition: Type 2 diabetes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-000133-39 Sponsor Protocol Number: 2019-02-07 Start Date*: 2019-05-08
    Sponsor Name:Academic Medical Center
    Full Title: A proof-of-concept study to evaluate 99mTechnetium radiolabeled Fucoidan as a diagnostic modality for thrombosis
    Medical condition: Deep vein thrombosis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002334-36 Sponsor Protocol Number: 2018/350/HP Start Date*: 2021-12-02
    Sponsor Name:CHU de Rouen
    Full Title: VASCULAR AND RENAL IMPACT OF ENDOTHELIN-1 RECEPTOR BLOCKADE IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION
    Medical condition: Resistant arterial hypertension
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038359 - Renal and urinary disorders 10038466 Renal hypertension and related conditions HLT
    20.0 100000004866 10038465 Renal hypertensions HLT
    21.1 10038359 - Renal and urinary disorders 10038464 Renal hypertension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2008-003972-23 Sponsor Protocol Number: hcc1 Start Date*: 2009-01-09
    Sponsor Name:LUMC
    Full Title: Hepatocellular carcinoma: vascular abnormalities prior to, during and following systemic anti-cancer treatment
    Medical condition: The primary objective of this study is to determine the efficacy of the combination of everolimus and capecitabine in a group of patients with metastatic or locally advanced HCC. In addition, to in...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019828 Hepatocellular carcinoma non-resectable LLT
    9.1 10019829 Hepatocellular carcinoma recurrent LLT
    9.1 10008452 Chemotherapy multiple agents systemic LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-000655-36 Sponsor Protocol Number: 80684 Start Date*: 2023-04-06
    Sponsor Name:Amsterdam UMC
    Full Title: Evaluation of GeranylGeranylAcetone in heart failure with preserved ejection fraction
    Medical condition: Heart Failure with preserved ejection fraction.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004950-27 Sponsor Protocol Number: VAL-02 Start Date*: 2014-02-06
    Sponsor Name:Sahlgrenska universitetssjukhuset
    Full Title: Effect of valproic acid on fibrinolysis in humans with atherosclerosis
    Medical condition: Atherosclerosis
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004866 10003601 Atherosclerosis LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-002766-73 Sponsor Protocol Number: PHT/2014/44 Start Date*: 2015-10-26
    Sponsor Name:Portsmouth Hospitals NHS Trust
    Full Title: The effect of oral Vitamin D supplementation on endothelial function, vascular inflammation, oxidative stress and insulin sensitivity in patients with impaired fasting glucose: A randomised, double...
    Medical condition: Impaired fasting glycaemia
    Disease: Version SOC Term Classification Code Term Level
    18.0 10027433 - Metabolism and nutrition disorders 10046242 Unspecified vitamin D deficiency LLT
    18.0 10027433 - Metabolism and nutrition disorders 10056997 Impaired fasting glucose PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-017676-24 Sponsor Protocol Number: CSPP100ADE07T Start Date*: 2010-02-26
    Sponsor Name:University Hospital Erlangen
    Full Title: Randomized, double blind, active-controlled, parallel study to analyse effects of the combination of aliskiren and valsartan on the vascular structure and function of retinal vessels
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    12.1 10020772 Hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2012-002278-30 Sponsor Protocol Number: CRC2012LINA Start Date*: 2012-08-13
    Sponsor Name:University Hospital Erlangen
    Full Title: Effects of Linagliptin on Renal Endothelium Function in Patients with Type 2 Diabetes.
    Medical condition: Diabetes mellitus
    Disease: Version SOC Term Classification Code Term Level
    14.1 10027433 - Metabolism and nutrition disorders 10012613 Diabetes mellitus non-insulin-dependent LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2021-002893-20 Sponsor Protocol Number: 2021/0188/HP Start Date*: 2021-12-03
    Sponsor Name:CHU de Rouen
    Full Title: Impact of dapagliflozin on vascular function in chronic kidney disease patients
    Medical condition: chronic kidney disease patients
    Disease: Version SOC Term Classification Code Term Level
    23.1 10038359 - Renal and urinary disorders 10064848 Chronic kidney disease PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-000320-40 Sponsor Protocol Number: SLx-2101-07-05 Start Date*: 2007-06-14
    Sponsor Name:Surface Logix, Inc.
    Full Title: A pilot Phase IIa randomised, double blind, placebo-controlled, crossover study to examine the safety, tolerability and pharmacodynamic effects on blood pressure of repeat oral doses of SLx-2101 5,...
    Medical condition: Hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020772 Hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-004243-74 Sponsor Protocol Number: CPRC2018/EVATRAN-GIRERD/JL Start Date*: 2020-06-02
    Sponsor Name:Centre Hospitalier Régional Universitaire de Nancy
    Full Title: A randomized crossover clinical trial regarding the blockage of the mineralocorticoid receptor using Eplerenone on the evolution of arterial stiffness in kidney patients one year after transplant: ...
    Medical condition: Patients with a kidney transplantation for more than one year and on cyclosporine
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10047065 Vascular disorders SOC
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-006787-25 Sponsor Protocol Number: 16122021 Start Date*: 2022-07-06
    Sponsor Name:Rigshospitalet The Heart Center
    Full Title: Effects of DAPAgliflozin on cardiopulmonary exercise capacity and hemodynamics in Pulmonary Arterial Hypertension: A double blind randomized trial
    Medical condition: Pulmonary arterial hypertension Chronic thromboembolic pulmonary hypertension
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10064911 Pulmonary arterial hypertension PT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10065150 Associated with pulmonary arterial hypertension LLT
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10065151 Idiopathic pulmonary arterial hypertension LLT
    24.1 10010331 - Congenital, familial and genetic disorders 10085244 Heritable pulmonary arterial hypertension PT
    21.0 10038738 - Respiratory, thoracic and mediastinal disorders 10068740 CTEPH LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2008-006644-19 Sponsor Protocol Number: CRISTAL Start Date*: 2009-01-29
    Sponsor Name:AZIENDA OSPEDALIERA SAN GERARDO DI MONZA
    Full Title: Evaluation of inflammatory immune parameters predicting cardiovascular risk in HIV-1-infected antiretroviral therapy naive patients treated with atazanavir/ritonavir versus lopinavir/ritonavir base...
    Medical condition: HIV infection
    Disease: Version SOC Term Classification Code Term Level
    9.1 10020161 HIV infection LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002107-15 Sponsor Protocol Number: Kirby-MARCH Start Date*: 2011-12-16
    Sponsor Name:Kirby Institute, University of New South Wa
    Full Title: Maraviroc Switch collaborative study A randomised, open-label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for either nucleoside or nucleotide analogue reverse transcr...
    Medical condition: Chronic HIV-1 infection
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021881 - Infections and infestations 10008919 Chronic HIV infection LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Completed) GB (Completed) DE (Completed) ES (Completed) PL (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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