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Clinical trials for children

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

  • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).


    The EU Clinical Trials Register currently displays   43876   clinical trials with a EudraCT protocol, of which   7294   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    Search Tips: Under advanced search you can use filters for Country, Age Group, Gender, Trial Phase, Trial Status, Date Range, Rare Diseases and Orphan Designation. For these items you should use the filters and not add them to your search terms in the text field.
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    4,033 result(s) found for: children. Displaying page 1 of 202.
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    EudraCT Number: 2008-001071-30 Sponsor Protocol Number: V1 Start Date*: 2010-01-21
    Sponsor Name:Medical University Vienna- Dept. of Pediatric Hemostaselology
    Full Title: Aspirin Resistance in Children after Interventional Cardiac Catheterization: The ARC Study
    Medical condition: children after interventional cardiac catheterization.
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-000606-11 Sponsor Protocol Number: 5502071979 Start Date*: Information not available in EudraCT
    Sponsor Name:Region Ostergotland
    Full Title: Melatonin compared to sleep deprivation for sleep EEG recordings in children: impact on epileptiform discharges and sleep, contributing factors on the results and the influence on children's and pa...
    Medical condition: suspected epilepsy
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-001735-37 Sponsor Protocol Number: FL-CR001 Start Date*: 2006-02-16
    Sponsor Name:FERRING ARZNEIMITTEL Ges.m.b.h. CEE AUSTRIA
    Full Title: AN OPEN LABEL STUDY OF ORAL DESMOPRESSIN IN CHILDREN AGED 5 TO 15 YEARS WITH PRIMARY NOCTURAL ENURESIS
    Medical condition: Primary noctural enuresis
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2020-001769-35 Sponsor Protocol Number: OYS042020. Start Date*: Information not available in EudraCT
    Sponsor Name:Oulu University Hopsital
    Full Title: Preventing urinary tract infections in infants and young children with probiotic E. coli Nissle: FinNiss- trial
    Medical condition: Urinary tract infection
    Disease:
    Population Age: Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000379-96 Sponsor Protocol Number: INnaloxonePed-1 Start Date*: 2017-05-05
    Sponsor Name:Karolinska University Hospital
    Full Title: Pharmacokinetic and pharmacodynamic aspects in children after intranasal administration of the opioid antagonist naloxone
    Medical condition: Pharmacokinetic profile after nasal naloxone administration in Children. In second part study reversal of sedation after opioid use
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-004958-34 Sponsor Protocol Number: UNOLE0457 Start Date*: 2015-01-30
    Sponsor Name:University of Leicester
    Full Title: Midazolam Measurement and Modelling using Matrix Samplers
    Medical condition: Not applicable
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-002094-55 Sponsor Protocol Number: 1861 Start Date*: 2019-09-09
    Sponsor Name:Universitair Ziekenhuis Brussel, Belgium
    Full Title: Safety and feasibility of S-Caine patch use in children under the age of three
    Medical condition: children under the age of three that are in possession of a central catheter and under permanent monitoring (healthy, or any condition)
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006736-22 Sponsor Protocol Number: NAF 03.4.05.033 Start Date*: 2007-02-14
    Sponsor Name:Netherlands Asthma Foundation (NAF) [...]
    1. Netherlands Asthma Foundation (NAF)
    2. Stichting astma bestrijding
    Full Title: An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation, and early lung function measurements
    Medical condition: children with recurrent respiratory symptoms)
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Not Authorised)
    Trial results: (No results available)
    EudraCT Number: 2013-002273-22 Sponsor Protocol Number: 1/2013 Start Date*: 2013-07-24
    Sponsor Name:Azienda Ospedaliera L. Sacco - Clinica Pediatrica
    Full Title: Efficacy of Pidotimod in the prevention of respiratory infections in healthy children: a randomized, double blind, placebo controlled study.
    Medical condition: respiratory infections in children.
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2016-002601-19 Sponsor Protocol Number: OND-URG Start Date*: 2019-09-16
    Sponsor Name:Basque Health Service
    Full Title: Effectiviness and safety of the administration of ondansetron versus placebo for the treatment of vomit in children with mild and moderate dehydration: randomized clinical trial
    Medical condition: Vomiting
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001817-40 Sponsor Protocol Number: NAF 3.4.05.003 Start Date*: 2007-05-10
    Sponsor Name:Netherlands Asthma Foundation (NAF) [...]
    1. Netherlands Asthma Foundation (NAF)
    2. Stichting astma bestrijding
    Full Title: An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation
    Medical condition: young children with recurrent respiratory symptoms
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001938-96 Sponsor Protocol Number: PGLIT2016 Start Date*: 2016-12-22
    Sponsor Name:Helsinki University Central Hospital
    Full Title: Treatment of Giardia lamblia infections in children: randomized open-labeled trial comparing rectal metronidazole with oral tinidazole
    Medical condition: Symptomatic Giardia lamblia infections in children
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: FI (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002925-29 Sponsor Protocol Number: 200605 Start Date*: 2005-09-20
    Sponsor Name:University Childrens Hospital
    Full Title: Irinotecan singele drug treatment for children with refractory or relapsed hepatoblastoma
    Medical condition: Refractory or recurrent hepatoblastoma
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2010-022655-29 Sponsor Protocol Number: RATE-trial Start Date*: 2011-05-30
    Sponsor Name:Erasmus MC
    Full Title: Randomised open label cross-over study into the efficacy of RApamycin in children with Tuberous sclerosis complex with intractable Epilepsy (RATE-trial)
    Medical condition: Epilepsy in children with Tuberous Sclerosis Complex
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-005016-93 Sponsor Protocol Number: Start Date*: 2005-04-01
    Sponsor Name:Vrinnevi Hospital
    Full Title: Oral immunoglobulin - a novel treatment of children with Crohn´s disease
    Medical condition: Children with the chronic inflammatory bowel Crohn´s disease in an active phase
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-006717-32 Sponsor Protocol Number: 554 Start Date*: 2007-01-31
    Sponsor Name:Stefan Lundeberg
    Full Title: Pharmacokinetic study of the opioid ketobemidone in children and adolescens after intravenous administration
    Medical condition: Pain treatment with opioids in children
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2006-002175-40 Sponsor Protocol Number: no number Start Date*: 2008-12-17
    Sponsor Name:
    Full Title: Effect of Botulinum Toxin A Injections and Specific Intensive Rehabilitation Therapy in Children with Hemiparetic Cerebral Palsy on Upper Limb Functions and Skills
    Medical condition: Study design: a factorial design with four study groups in which btA alone, intensive rehabilitation therapy aimed at improving bimanual skills alone, a combination of these two and continuing the ...
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002323-28 Sponsor Protocol Number: prop01 Start Date*: 2016-06-28
    Sponsor Name:Universitair Ziekenhuis Brussel
    Full Title: Blood concentration and pharmacokinetic analysis of propofol following administration of single induction dose in small children
    Medical condition: Children scheduled for elective surgery
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-023976-16 Sponsor Protocol Number: Matab2 Start Date*: 2010-02-08
    Sponsor Name:University of Antwerp
    Full Title: Maternal antibodies against pertussis in neonates .
    Medical condition: Pertussis disease is reported in very young children who have not yet been (fully) vaccinated and did not receive sufficient maternal antibodies. Augmenting maternal antibody titers by administerin...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-023844-34 Sponsor Protocol Number: ParCS Start Date*: 2011-06-30
    Sponsor Name:Sint Maartenskliniek
    Full Title: Effectiveness and safety of parecoxib in children undergoing scoliosis surgery compared to placebo: a double-blinded randomised controlled trial
    Medical condition: Postoperative pain in children after scoliosis surgergy (spinal fusion). The morphine consumption on the first two postoperative days will be assessed. Children: <18 years old, ASA I or II
    Disease: Version SOC Term Classification Code Term Level
    12.1 10039727 Scoliosis surgery PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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