E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Complicated intra-abdominal Infections |
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MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 8.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10056570 |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
Primary objective is to compare the safety and efficacy of intravenous moxifloxacin 400 mg administered once daily with those of intravenous ertapenem 1 g once a day in adult subjects with cIAI that require surgery and parenteral antibiotic therapy
The primary efficacy variable for this trial is the clinical response 21 to 28 days after the completion of study drug therapy (Test of Cure visit). |
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E.2.2 | Secondary objectives of the trial |
Secondary efficacy parameters are: • Clinical and bacteriological response on treatment Day 5 +/- 1. • Clinical and bacteriological response at the End-of-Therapy (EOT). • Bacteriological response at the TOC visit (21 28 days after EOT). • Clinical response at the TOC visit in subjects with a bacteriologically documented intra abdominal infection. • Mortality attributable to intra abdominal infections at the time of the TOC visit (21 to 28 days after EOT). • Duration of hospitalization (total days). • Duration of hospitalization postoperatively (days).
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E.2.3 | Trial contains a sub-study | Information not present in EudraCT |
E.3 | Principal inclusion criteria |
Subjects must meet all the following inclusion criteria: 1. Hospitalized men or women >/= 18 years of age. 2. Expected duration of treatment with intravenous antibiotics anticipated to be >/= 5 full days but not exceeding 14 days. 3. Ability to provide documented and signed written informed consent. 4. Confirmed or suspected intra abdominal infection defined as follows: . For a confirmed intra abdominal infection, a surgical procedure (laparotomy or laparoscopy) must have been performed within 24 hours prior to enrollment and reveal at least one of the following: • Gross peritoneal inflammation with purulent exudates (ie, peritonitis). • Intra abdominal abscess. • Macroscopic intestinal perforation with localized or diffuse peritonitis. . Subjects enrolled on the basis of a suspected intra abdominal infection must have: 1. Radiological evidence [abdominal plain films, computed tomography (CT), magnetic resonance imaging (MRI) or ultrasound] of gastrointestinal perforation or intra-abdominal abscess and 2. The following signs and symptoms: • Symptoms referable to the abdominal cavity (eg, anorexia, nausea, vomiting or pain), lasting for at least 24 hours. • Tenderness (with or without rebound), involuntary guarding, absent or diminished bowel sounds, or abdominal wall rigidity. • At least two of the following SIRS criteria (23): . Temperature > 38.0°C rectal or tympanic membrane, or temperature < 36.0°C rectal or tympanic. . Heart rate > 90/min. . Respiratory rate > 20/min. . WBC >12,000 cells/mm3 or < 4,000 cells/ mm3. and 3. The subject must be scheduled for a surgical procedure (laparotomy or laparoscopy) within 24 hours of enrollment of the study.
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E.4 | Principal exclusion criteria |
1) Known hypersensitivity to quinolones, and/or to carbapenems and/or to any other type of beta lactam antibiotic drugs (eg, penicillins or cephalosporins), or any of the excipients. 2) Women who are pregnant or lactating or in whom pregnancy cannot be excluded (Note: a urine pregnancy test has to be performed for all women of childbearing potential before inclusion into the study). 3) History of tendon disease/disorder related to quinolone treatment. 4) Known congenital or documented acquired QT prolongation; uncorrected hypokalemia; clinically relevant bradycardia; clinically relevant heart failure with reduced left ventricular ejection fraction; previous history of symptomatic arrhythmias. 5) Concomitant use of any of the following drugs, reported to increase the QT interval: antiarrhythmics class IA (eg, quinidine, hydroquinidine, disopyramide) or antiarrhythmics class III (eg, amiodarone, sotalol, dofetilide, ibutilide), neuroleptics (eg, phenothiazines, pimozide, sertindole, haloperidol, sultopride), tricyclic antidepressive agents, certain antimicrobials (sparfloxacin, erythromycin IV, pentamidine, antimalarials, particularly halofantrine), certain antihistaminics (terfenadine, astemizole, mizolastine), and others (cisapride, vincamine IV, bepridil, diphemanil). 6) Known severe end stage liver disease (Child Pugh C, see Appendix 10.2). 7) Creatinine clearance </= 30 mL/min/1.73 m2 (the Cockroft-Gault formula for calculating creatinine clearance is given in Appendix 10.5). 8) Systemic antibacterial therapy administered for more than 24 hours within 7 days of enrollment. 9) Need for systemic antibacterial therapy with agents other than those described in the study protocol (Note: prophylactic anti-fungal therapy is accepted). 10) Indwelling peritoneal catheter. 11) Pre existing ascites and presumed spontaneous bacterial peritonitis. 12) Perforation of the stomach or duodenum, if the duration of perforation is less than 24 hours or if operated on within 24 hours of perforation. 13) perforation of the small bowel (excluding the duodenum) or large bowel, if the duration of perforation is less than 12 hours or if operated on within 12 hours of perforation. 14) All pancreatic processes including pancreatic sepsis, peri-pancreatic sepsis, or an intra abdominal infection secondary to pancreatitis. 15) Liver and splenic abscess. 16) Transmural bowel ischemia or necrosis without perforation or established peritonitis or abscess. 17) Acute and gangrenous cholecystitis without perforation. 18) Acute cholangitis. 19) Early acute, suppurative, or gangrenous non-perforated appendicitis. 20) Subjects requiring antibiotic irrigations of the abdominal cavity or surgical wound. 21) Treatment with "open abdomen" or marsupialization, or multiple planned re laparotomies. 22) Infections originating from the female genital tract. 23) Peri-nephric infections. 24) Evidence of sepsis with shock requiring the administration of vasopressors for more than 4 consecutive hours. 25) Known rapidly fatal underlying disease (death expected within 6 months). 26) Neutropenia (neutrophil count < 1,000/µL) caused by immunosuppressive therapy or malignancy. 27) Receiving chronic treatment with known immunosuppressant therapy (including chronic treatment with > 15 mg/day of systemic prednisone or equivalent). 28) Subjects known to have AIDS (CD4 count < 200/µL) or HIV seropositives who are receiving HAART (Note: HIV positive subjects may be included. HIV testing is not required for this study protocol). 29) Subjects with a malignant or pre malignant hematological condition, including Hodgkin’s disease and non-Hodgkin lymphoma (subjects with solid tumor can be included in the study). 30) Subjects with a Body Mass Index >/= 45 kg/m2. 31) Previous enrollment in this study. 32) Participation in any clinical investigational drug study within the previous 4 weeks.
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E.5 End points |
E.5.1 | Primary end point(s) |
The primary efficacy variable for this trial is the clinical response 21 to 28 days after the completion of study drug therapy (Test of Cure visit). |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | Yes |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | No |
E.6.7 | Pharmacodynamic | No |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | Information not present in EudraCT |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | No |
E.7.3 | Therapeutic confirmatory (Phase III) | Yes |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | Yes |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | Yes |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | Yes |
E.8.1.7.1 | Other trial design description |
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E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | Yes |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | No |
E.8.3 |
The trial involves single site in the Member State concerned
| Information not present in EudraCT |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | Information not present in EudraCT |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
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E.8.7 | Trial has a data monitoring committee | Information not present in EudraCT |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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End of Trial is defined as Clean Database |
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | |
E.8.9.1 | In the Member State concerned months | |
E.8.9.1 | In the Member State concerned days | |
E.8.9.2 | In all countries concerned by the trial years | 2 |