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    Summary
    EudraCT Number:2007-001162-32
    Sponsor's Protocol Code Number:CAMMS 324
    National Competent Authority:France - ANSM
    Clinical Trial Type:EEA CTA
    Trial Status:Completed
    Date on which this record was first entered in the EudraCT database:2008-01-08
    Trial results View results
    Index
    A. PROTOCOL INFORMATION
    B. SPONSOR INFORMATION
    C. APPLICANT IDENTIFICATION
    D. IMP IDENTIFICATION
    D.8 INFORMATION ON PLACEBO
    E. GENERAL INFORMATION ON THE TRIAL
    F. POPULATION OF TRIAL SUBJECTS
    G. INVESTIGATOR NETWORKS TO BE INVOLVED IN THE TRIAL
    N. REVIEW BY THE COMPETENT AUTHORITY OR ETHICS COMMITTEE IN THE COUNTRY CONCERNED
    P. END OF TRIAL
    Expand All   Collapse All
    A. Protocol Information
    A.1Member State ConcernedFrance - ANSM
    A.2EudraCT number2007-001162-32
    A.3Full title of the trial
    A Phase 3 Randomized, Rater- and Dose-Blinded Study Comparing Two Annual Cycles of Intravenous Low- and High-Dose Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif®) in Patients with Relapsing-Remitting Multiple Scleroris Who Have Relapsed On Therapy
    A.3.2Name or abbreviated title of the trial where available
    CARE MS-II
    A.4.1Sponsor's protocol code numberCAMMS 324
    A.5.1ISRCTN (International Standard Randomised Controlled Trial) Numbernot available
    A.7Trial is part of a Paediatric Investigation Plan Information not present in EudraCT
    A.8EMA Decision number of Paediatric Investigation Plan
    B. Sponsor Information
    B.Sponsor: 1
    B.1.1Name of SponsorGenzyme Corporation
    B.1.3.4CountryUnited States
    B.3.1 and B.3.2Status of the sponsorCommercial
    B.4 Source(s) of Monetary or Material Support for the clinical trial:
    B.4.1Name of organisation providing support
    B.4.2Country
    B.5 Contact point designated by the sponsor for further information on the trial
    B.5.1Name of organisation
    B.5.2Functional name of contact point
    D. IMP Identification
    D.IMP: 1
    D.1.2 and D.1.3IMP RoleTest
    D.2 Status of the IMP to be used in the clinical trial
    D.2.1IMP to be used in the trial has a marketing authorisation Yes
    D.2.1.1.1Trade name MabCampath ®
    D.2.1.1.2Name of the Marketing Authorisation holderGenzyme Europe B.V.
    D.2.1.2Country which granted the Marketing AuthorisationEuropean Union
    D.2.5The IMP has been designated in this indication as an orphan drug in the Community No
    D.2.5.1Orphan drug designation number
    D.3 Description of the IMP
    D.3.1Product nameAlemtuzumab
    D.3.4Pharmaceutical form Solution for infusion
    D.3.4.1Specific paediatric formulation Information not present in EudraCT
    D.3.7Routes of administration for this IMPIntravenous use
    D.3.8 to D.3.10 IMP Identification Details (Active Substances)
    D.3.8INN - Proposed INNAlemtuzumab
    D.3.10 Strength
    D.3.10.1Concentration unit mg/ml milligram(s)/millilitre
    D.3.10.2Concentration typeequal
    D.3.10.3Concentration number10
    D.3.11 The IMP contains an:
    D.3.11.1Active substance of chemical origin No
    D.3.11.2Active substance of biological/ biotechnological origin (other than Advanced Therapy IMP (ATIMP) Yes
    The IMP is a:
    D.3.11.3Advanced Therapy IMP (ATIMP) Information not present in EudraCT
    D.3.11.3.1Somatic cell therapy medicinal product No
    D.3.11.3.2Gene therapy medical product No
    D.3.11.3.3Tissue Engineered Product Information not present in EudraCT
    D.3.11.3.4Combination ATIMP (i.e. one involving a medical device) Information not present in EudraCT
    D.3.11.3.5Committee on Advanced therapies (CAT) has issued a classification for this product Information not present in EudraCT
    D.3.11.4Combination product that includes a device, but does not involve an Advanced Therapy Information not present in EudraCT
    D.3.11.5Radiopharmaceutical medicinal product No
    D.3.11.6Immunological medicinal product (such as vaccine, allergen, immune serum) No
    D.3.11.7Plasma derived medicinal product No
    D.3.11.8Extractive medicinal product No
    D.3.11.9Recombinant medicinal product Information not present in EudraCT
    D.3.11.10Medicinal product containing genetically modified organisms No
    D.3.11.11Herbal medicinal product No
    D.3.11.12Homeopathic medicinal product No
    D.3.11.13Another type of medicinal product Yes
    D.3.11.13.1Other medicinal product typeHumanised Monoclonal Antibody
    D.IMP: 2
    D.1.2 and D.1.3IMP RoleComparator
    D.2 Status of the IMP to be used in the clinical trial
    D.2.1IMP to be used in the trial has a marketing authorisation Yes
    D.2.1.1.1Trade name Rebif
    D.2.1.1.2Name of the Marketing Authorisation holderSerono Europe Limited
    D.2.1.2Country which granted the Marketing AuthorisationEuropean Union
    D.2.5The IMP has been designated in this indication as an orphan drug in the Community No
    D.2.5.1Orphan drug designation number
    D.3 Description of the IMP
    D.3.4Pharmaceutical form Solution for injection
    D.3.4.1Specific paediatric formulation Information not present in EudraCT
    D.3.7Routes of administration for this IMPSubcutaneous use
    D.3.8 to D.3.10 IMP Identification Details (Active Substances)
    D.3.8INN - Proposed INNINTERFERON BETA-1A
    D.3.10 Strength
    D.3.10.1Concentration unit µg microgram(s)
    D.3.10.2Concentration typeequal
    D.3.10.3Concentration number44
    D.3.11 The IMP contains an:
    D.3.11.1Active substance of chemical origin No
    D.3.11.2Active substance of biological/ biotechnological origin (other than Advanced Therapy IMP (ATIMP) Yes
    The IMP is a:
    D.3.11.3Advanced Therapy IMP (ATIMP) Information not present in EudraCT
    D.3.11.3.1Somatic cell therapy medicinal product No
    D.3.11.3.2Gene therapy medical product No
    D.3.11.3.3Tissue Engineered Product Information not present in EudraCT
    D.3.11.3.4Combination ATIMP (i.e. one involving a medical device) Information not present in EudraCT
    D.3.11.3.5Committee on Advanced therapies (CAT) has issued a classification for this product Information not present in EudraCT
    D.3.11.4Combination product that includes a device, but does not involve an Advanced Therapy Information not present in EudraCT
    D.3.11.5Radiopharmaceutical medicinal product No
    D.3.11.6Immunological medicinal product (such as vaccine, allergen, immune serum) No
    D.3.11.7Plasma derived medicinal product No
    D.3.11.8Extractive medicinal product No
    D.3.11.9Recombinant medicinal product Information not present in EudraCT
    D.3.11.10Medicinal product containing genetically modified organisms No
    D.3.11.11Herbal medicinal product No
    D.3.11.12Homeopathic medicinal product No
    D.3.11.13Another type of medicinal product Yes
    D.3.11.13.1Other medicinal product typeglycoprotein (produced in Chinese Hamster Ovary Cells (CHO-K1))
    D.8 Information on Placebo
    E. General Information on the Trial
    E.1 Medical condition or disease under investigation
    E.1.1Medical condition(s) being investigated
    Relapsing Remitting Multiple Sclerosis
    MedDRA Classification
    E.1.2 Medical condition or disease under investigation
    E.1.2Version 9.1
    E.1.2Level LLT
    E.1.2Classification code 10063399
    E.1.2Term Relapsing-remitting multiple sclerosis
    E.1.3Condition being studied is a rare disease No
    E.2 Objective of the trial
    E.2.1Main objective of the trial
    The main objectives of study CAMMS324 is to compare the safety and efficacy of 2 annual cycles of either low- (12 mg/day) or high-dose (24 mg/day) intravenous (IV) alemtuzumab to 3-times weekly subcutaneous (SC) interferon beta-1a (Rebif) in patients with active relpasing-remitting multiple sclerosis (RRMS) who have experienced at least 1 relapse while on disease-modifying drug therapy for > 6 months.
    E.2.2Secondary objectives of the trial
    Secondary objectives of the CAMMS324 trial are:
    - Proportion of patients who are relapse free at Year 2
    - Change from baseline in EDSS
    - Acquisition of disability as measured by change from baseline in MSFC
    - Percent change from baseline in MRI-T2-hyperintense lesion volume at Year 2
    E.2.3Trial contains a sub-study Yes
    E.2.3.1Full title, date and version of each sub-study and their related objectives
    Four sub-studies are included in this protocol (same protocol version number and date) which will be conducted at selected centres on a subpopulation of patients:
    - Laboratory substudy. Additional testing for the following parameters: expanded hematology, expanded thyroid function monitoring, expanded lymphocyte phenotyping, peripheral blood mononuclear cell (PBMC)
    - Semen substudy. Semen analysis of sperm count and motility. If agglutination is present, subsequent testing for anti-sperm antibodies.
    - Expanded imaging substudy. Additional MTR (to measure abnormalities in normal-appearing white matter, which may be indicative of demyelination associated with the effects of MS) and/or MRS (thought to be a marker for axonal preservation and thus a useful counterpoint to MTR measurement of demyelination) and/or DWI (measuring diffusion of water in tissues, which can be adapted to reveal the state of white matter including demylenating MS lesions)
    - Pharmacokinetic substudy. PK samples drawn in two sub-cohorts (dense or sparse collection)
    E.3Principal inclusion criteria
    • Signed, informed consent form
    • Age 18 to 50 years old (inclusive) as of signing informed consent form (ICF)
    • Diagnosis of MS per update of McDonald criteria
    • Onset of MS symptoms (as determined by a neurologist) within 5 years prior to screening
    • EDSS score 0.0 to 5.0 (inclusive)
    • >/= 2 MS attacks (first episode or relpases) occurring in the 2 years prior to screening, with >/= 1 attack prior to screening, with objective neurological signs confirmed by a physician
    • >/= 6 months continous treatment with beta interferon or glatiramer acetate during the past 5 years prior to screening
    • >/= 1 MS attack (replase) during treatment with interferon beta or glatiramer acetate after being on that therapy for at least 6 months; relapses that occur within 6 months of initiating treatment with interferon beta or glatiramer acetate do not qualify as a relapse during treatment
    • MRI scanning demonstrating white matter lesions attributable to MS and meeting at least one of the following criteria, as determined by the treating neurologist
    - >/= 9 TS lesions at least 3 mm in any axis
    - a gadolinium-enhancing lesion at least 3 mm in any axis plus >/= 1 brain T2 lesions
    - a spinal cord lesion consistent with MS plus >/= 1 brain T2 lesions
    E.4Principal exclusion criteria
    •Previous treatment with alemtuzumab or any other investigational drug for MS
    • Previous treatment with mitoxantrone or natalizumab
    • Exposure to azathioprine, cladiribine, cyclophosphamide, cyclosporine A, methotrexate, or any other immunosuppressive agent other than systemic corticosteroid treatment
    • Received treatment with a monoclonal antibody for any reason
    • Has any progressive form of MS
    • History of malignancy (except for basal cell skin carcinoma if disease-free for >/=5 years)
    • Any disability acquired from trauma or another illness that, in the opinion of the Investigator, could interfere with evaluation of disability due to MS
    • Previous hypersensitivity reaction to other immunoglobulin product
    • Known allergy or intolerance to interferon beta, human albumin, or mannitol
    • Intolerance of pulsed corticosteroids, especially a history of steroid psychosis
    • Inability to self-administer SC injections or receive SC injections from caregiver
    • Inability to undergo MRI with gadolinium administration
    • Documented CD4+ cell count <490/mm3 within the past year
    • Documented CD8+ cell count <200/mm3 within the past year
    • Seropositivity for human immunodeficiency virus (HIV)
    • Significant autoimmune disease (eg, immune cytopenias, rheumatoid arthritis, systemic lupus erythematosus, other connective tissue disorders; vasculitis; inflammatory bowel disease; severe psoriasis)
    • Presence of anti-TSH receptor antibodies
    • Active infection, eg, deep-tissue infection, that the Investigator considers sufficiently serious to preclude study participation
    • Latent tuberculosis unless effective anti-tuberculosis therapy has been completed, or active tuberculosis. More specific guidance on tuberculosis testing and patient eligibility is provided in the Study Operations Manual (SOM)
    • Infection with hepatitis B virus or hepatitis C virus
    • Of childbearing potential with a positive serum pregnancy test
    • Unwilling to agree to use a reliable and acceptable contraceptive method throughout the study period (fertile patients only); reliable and effective contraceptive method(s) include: condoms (male or female) with or without a spermicidal agent, diaphragm with spermicide or cervical cap, intrauterine device [IUD], or hormonal-based contraception
    • Major psychiatric disorder that is not adequately controlled by treatment
    • Epileptic seizures that are not adequately controlled by treatment
    • Major systemic disease or other illness that would, in the opinion of the Investigator, compromise patient safety or interfere with the interpretation of study results
    • Current participation in another clinical study or previous participation in CAMMS 323
    • Medical, psychiatric, cognitive, or other conditions that, in the Investigator’s opinion, compromise the patient's ability to understand the patient information, to give informed consent, to comply with the trial protocol, or to complete the study
    • Confirmed platelet count <130,000/uL at Screening or documented at < 100,000/uL within the past year on a sample without platelet clumping
    • Prior history of invasive fungal infections
    • History of untreated cervical dysplasia or intraepithelial neoplasia (CIN)
    • Seropositive for Trypanosoma cruzi of Human T-lymphotropic virus type I or type II (HTLV-I/II) (testing in endemic regions only). Guidance on region-specific testing recomemndations and patient eligibility is provided in the SOM
    • Any other illness or infection (latent or active) that, in the Investigator's opinion, could be execerbated by alemtuzumab treatment
    • Any hepatic or renal function value grade 2 or higher at Screening with the exception of hyperbilirubinemia due to Gilbert's syndrome.
    E.5 End points
    E.5.1Primary end point(s)
    The study will be considered to have met its efficacy objectives if a statistically significant treatment effect of either alemtuzumab dose level over SC interferon beta-1a is demonstrated in either or both of the co-primary efficacy endpoints: time to SAD and relapse rate.
    E.6 and E.7 Scope of the trial
    E.6Scope of the trial
    E.6.1Diagnosis No
    E.6.2Prophylaxis No
    E.6.3Therapy Yes
    E.6.4Safety Yes
    E.6.5Efficacy Yes
    E.6.6Pharmacokinetic Yes
    E.6.7Pharmacodynamic No
    E.6.8Bioequivalence No
    E.6.9Dose response No
    E.6.10Pharmacogenetic No
    E.6.11Pharmacogenomic No
    E.6.12Pharmacoeconomic Yes
    E.6.13Others No
    E.7Trial type and phase
    E.7.1Human pharmacology (Phase I) No
    E.7.1.1First administration to humans No
    E.7.1.2Bioequivalence study No
    E.7.1.3Other No
    E.7.1.3.1Other trial type description
    E.7.2Therapeutic exploratory (Phase II) No
    E.7.3Therapeutic confirmatory (Phase III) Yes
    E.7.4Therapeutic use (Phase IV) No
    E.8 Design of the trial
    E.8.1Controlled Yes
    E.8.1.1Randomised Yes
    E.8.1.2Open Yes
    E.8.1.3Single blind No
    E.8.1.4Double blind No
    E.8.1.5Parallel group Yes
    E.8.1.6Cross over No
    E.8.1.7Other No
    E.8.2 Comparator of controlled trial
    E.8.2.1Other medicinal product(s) Yes
    E.8.2.2Placebo No
    E.8.2.3Other No
    E.8.3 The trial involves single site in the Member State concerned No
    E.8.4 The trial involves multiple sites in the Member State concerned Yes
    E.8.4.1Number of sites anticipated in Member State concerned9
    E.8.5The trial involves multiple Member States Yes
    E.8.5.1Number of sites anticipated in the EEA41
    E.8.6 Trial involving sites outside the EEA
    E.8.6.1Trial being conducted both within and outside the EEA Yes
    E.8.6.2Trial being conducted completely outside of the EEA Information not present in EudraCT
    E.8.6.3If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned
    E.8.7Trial has a data monitoring committee Yes
    E.8.8 Definition of the end of the trial and justification where it is not the last visit of the last subject undergoing the trial
    End of trial = 2 years from the date the last patient is randomised to treatment. All patients will be invited to participate in a separate extention protocol to provide long-term follow up, including safety monitoring for at least 3 years following their last alemtuzumab treatment
    E.8.9 Initial estimate of the duration of the trial
    E.8.9.1In the Member State concerned years3
    E.8.9.1In the Member State concerned months
    E.8.9.1In the Member State concerned days
    E.8.9.2In all countries concerned by the trial years3
    F. Population of Trial Subjects
    F.1 Age Range
    F.1.1Trial has subjects under 18 No
    F.1.1.1In Utero Information not present in EudraCT
    F.1.1.2Preterm newborn infants (up to gestational age < 37 weeks) Information not present in EudraCT
    F.1.1.3Newborns (0-27 days) Information not present in EudraCT
    F.1.1.4Infants and toddlers (28 days-23 months) Information not present in EudraCT
    F.1.1.5Children (2-11years) Information not present in EudraCT
    F.1.1.6Adolescents (12-17 years) Information not present in EudraCT
    F.1.2Adults (18-64 years) Yes
    F.1.3Elderly (>=65 years) No
    F.2 Gender
    F.2.1Female Yes
    F.2.2Male Yes
    F.3 Group of trial subjects
    F.3.1Healthy volunteers No
    F.3.2Patients Yes
    F.3.3Specific vulnerable populations Yes
    F.3.3.1Women of childbearing potential not using contraception No
    F.3.3.2Women of child-bearing potential using contraception Yes
    F.3.3.3Pregnant women No
    F.3.3.4Nursing women No
    F.3.3.5Emergency situation No
    F.3.3.6Subjects incapable of giving consent personally No
    F.3.3.7Others No
    F.4 Planned number of subjects to be included
    F.4.1In the member state50
    F.4.2 For a multinational trial
    F.4.2.1In the EEA 329
    F.4.2.2In the whole clinical trial 1200
    F.5 Plans for treatment or care after the subject has ended the participation in the trial (if it is different from the expected normal treatment of that condition)
    Treatment post-study will be normal standard of care for RRMS. However, patients will be invited to participate in a separate extention protocol to provide long-term follow-up, including safety monitoring for at least 3 years following their last alemtuzumab treatment after the present study ends.
    G. Investigator Networks to be involved in the Trial
    N. Review by the Competent Authority or Ethics Committee in the country concerned
    N.Competent Authority Decision Authorised
    N.Date of Competent Authority Decision2008-04-11
    N.Ethics Committee Opinion of the trial applicationFavourable
    N.Ethics Committee Opinion: Reason(s) for unfavourable opinion
    N.Date of Ethics Committee Opinion2008-02-19
    P. End of Trial
    P.End of Trial StatusCompleted
    P.Date of the global end of the trial2011-09-15
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