E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Patient with chronic lymphocytic leukemia (CLL) requiring therapy with a high risk factor such as 17p deletion or refractoriness to fludarabine .
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MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 9.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10008976 |
E.1.2 | Term | Chronic lymphocytic leukemia |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 9.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10008978 |
E.1.2 | Term | Chronic lymphocytic leukemia refractory |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
Assessment of the efficacy of the study treatment in the study population in terms of: – Response rate
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E.2.2 | Secondary objectives of the trial |
Progression-free survival, defined as time from study entry until diagnosis of PD or death of any cause • Failure-free survival, defined as time from study entry until initiation of next treatment, diagnosis of PD or death of any cause. • Overall survival, defined as time from study entry until death. • Acquisition of further data to expand the data base on the toxicity of the study treatment. • Assessment of the efficacy of the study treatment in biological risk groups. • Assessment of response in terms of MRD.
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
The following criteria are to be checked at the time of study entry. The patient may only be included if all of the following statements are true: 1. The patient has CLL requiring treatment (Binet C or A/B with “active disease” according to the NCI criteria). 2.One or both of the following is true: • The patient's disease is refractory to any previous fludarabine-containing regimen, defined as no CR or PR according to NCI criteria, or progression within 6 months after any fludarabine-containing regime. (N.B.: Within the framework of this trial, the term “fludarabine-refractory” is synonymous to a refractory status to any established purine analogue (i.e. pentostatin, cladribine). It also encompasses bendamustine, as this drug molecule contains both an alkylating and a purine analogue moiety. Acc. to experimental findings and clinical experience, its mechanism of action differs distinctly from that of a pure alkylator). • 17p deletion is present (irrespective of whether previously treated or untreated). 3. The patient is at least 18 years of age. 4. The patient's performance status is 0, 1 or 2 on the WHO/ECOG scale. 5. Any previous chemotherapy and/or immunotherapy ended at least four weeks before the first study treatment with alemtuzumab. 6. The patient has recovered from all previous chemotherapy and/or immunotherapy. 7. For fertile men and for women of childbearing potential: Adequate contraception (oral contraceptives, intrauterine device or barrier method in conjunction with spermicidal jelly). 8. The patient has given written informed consent to participate in the study.
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E.4 | Principal exclusion criteria |
The following criteria are to be checked at the time of study entry. The patient must be excluded if any one (or more) of the following statements is true: 1. The patient has received more than five different prior therapeutic regimens. 2.Any major organ dysfunction is present (e.g. unstable angina pectoris, NYHA III/IV heart insufficiency, significant coronary stenoses, uncontrolled diabetes mellitus, uncontrolled hypertension, pulmonary disease with hypoxemia, renal failure). 3. Any of the following laboratory values are found at the screening visit to be >2x the upper limit of the normal range: serum creatinine, serum bilirubin, ASAT, ALAT. 4. Any active infection is present. 5. B-PLL or Richter transformation is diagnosed or suspected (symptoms or cytology). 6. There is involvement of the central nervous system. 7. The patient is known to be positive for human immunodeficiency virus (HIV). 8. CMV viremia is present, as demonstrated by pp65 EA or CMV-DNA. 9. The patient has previously been treated with alemtuzumab. (Exception: alemtuzumab used in a “non-therapeutic” context, i.e. administered as part of a conditioning regimen prior to SCT). 10. The patient has received autologous or allogeneic SCT within the past six months. 11. The patient is receiving long-term systemic treatment with corticosteroids or has received such treatment in the four weeks before first treatment with alemtuzumab. 12. Any additional active malignancy is present. 13. The patient has ever had an anaphylactic response to humanized antibodies. 14. For female patients: The patient is pregnant or lactating. 15. The patient has a history of drug or alcohol abuse that might lead to inability to comply with the protocol.
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E.5 End points |
E.5.1 | Primary end point(s) |
The objective response rate (ORR = number of patients with CR or PR / number of evaluable subjects) according to the NCI working-group criteria.
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | Yes |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | No |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | No |
E.8.1.1 | Randomised | No |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | No |
E.8.3 |
The trial involves single site in the Member State concerned
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E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 26 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 47 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | No |
E.8.6.2 | Trial being conducted completely outside of the EEA | Information not present in EudraCT |
E.8.7 | Trial has a data monitoring committee | Yes |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 8 |
E.8.9.1 | In the Member State concerned months | 0 |
E.8.9.1 | In the Member State concerned days | 0 |
E.8.9.2 | In all countries concerned by the trial years | 8 |
E.8.9.2 | In all countries concerned by the trial months | 0 |
E.8.9.2 | In all countries concerned by the trial days | 0 |