E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
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MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 9.1 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10028228 |
E.1.2 | Term | Multiple myeloma |
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E.1.3 | Condition being studied is a rare disease | Yes |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
1. To determine the safety and tolerability of SRT501 (5.0 g), with or without concurrent bortezomib administration, when administered once daily in 21 day cycles, in male and female subjects with Multiple Myeloma. 2. To define objective response (ORR, CR, PR, MR, SD) and time to progression (TTP) of SRT501 in male and female subjects with Multiple Myeloma. 3. To define objective response (ORR, CR, PR, MR, SD) and time to progression (TTP) of SRT501 and bortezomib administered concurrently in male and female subjects with Multiple Myeloma. |
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E.2.2 | Secondary objectives of the trial | |
E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
1. Subject must be male or female ≥ 18 years at the time of signing Informed Consent. 2. Subject was previously diagnosed with Multiple Myeloma and has failed at least one prior treatment regimen for the disease. 3. Subject must have measurable disease. 4. Subjects must have relapsed or relapsed/refractory disease as defined in Appendix 4. 5. Subject must have a life expectancy of greater than 6 months. 6. Subject has an ECOG Performance status of 0 to 2 (Appendix 2). 7. Subject has no prior history of HIV-1, HIV-2, Hepatitis B or C infection. 8. Subject has a normal 12 lead ECG or an ECG with an abnormality considered to be clinically insignificant. 9. Subject has the ability to communicate with the investigative site staff in a manner sufficient to carry out all protocol procedures as described. 10. Subject must be able to adhere to the study visit schedule and other protocol requirements. 11. Subject must understand and voluntarily sign an informed consent document. 12. All subjects of reproductive potential must agree prior to study entry to use adequate contraception (hormonal or double barrier method of birth control; abstinence) for the duration of the study dosing and at least 12 weeks after completion of study drug. 13. Adequate end organ function, defined as the following: • Total bilirubin < 2 x ULN, unless attributable to Gilbert’s disease • ALT (SGPT) and AST (SGOT) < 2.5 x ULN • Creatinine < 2.0 x ULN • ANC > 0.5 x 109/L • Platelets > 20,000 cells/mm3 |
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E.4 | Principal exclusion criteria |
1. Intolerance to resveratrol, SRT501 or bortezomib or significant allergy to either compound, boron or mannitol or significant prior toxicity with either agent that would preclude the safe use of that agent. Prior therapy with either compound is permitted. 2. Subjects with other active malignancy, with the exception of basal cell or squamous cell carcinoma of the skin. 3. An uncontrolled intercurrent illness including, but not limited to, recent (≤ 6 months), ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, acute diffuse infiltrative pulmonary or pericardial disease, or psychiatric illness/social situations that would limit compliance with study requirements. 4. Subject with a history of or current gastro-intestinal diseases influencing drug absorption, with the exception of an appendectomy. 5. Women who are breast-feeding, pregnant, expect to become pregnant during the course of the study, or are sexually active in a heterosexual relationship and are not using a medically acceptable double barrier method birth control. Confirmation that the subject is not pregnant must be established by a negative serum β-hCG pregnancy test result obtained during the Screening period. Pregnancy testing is not required for post-menopausal or surgically sterilized women. Women relying solely on oral contraceptives for birth control are excluded. 6. Subjects who have had chemotherapy or radiotherapy within 4 weeks prior to signing Informed Consent or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier. 7. Subjects who are on any concurrent medications that may exhibit anti-neoplastic therapy, with the exception of < 10 mg of prednisone or equivalent as indicated for other medical conditions, or up to 100 mg of hydrocortisone as premedication for administration of certain medications or blood products. 8. Subjects currently taking any investigational therapies and/or dietary supplements containing resveratrol. 9. Subjects with peripheral neuropathy of Grade 2 or greater. 10. Subjects with uncontrolled bleeding. 11. Subjects with evidence of mucosal or internal bleeding and/or platelet refractory (i.e., unable to maintain a platelet count ≥ 20,000 cells/mm3). 12. Subjects with a hemoglobin < 8.0 g/dL. Transfusions and/or EPO treatment are permitted in subjects who are potentially excluded by this criteria. 13. Any condition, including laboratory abnormalities, that in the opinion of the Investigator, would preclude treatment. |
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E.5 End points |
E.5.1 | Primary end point(s) |
1. To determine the safety and tolerability of SRT501 (5.0 g), with or without concurrent bortezomib administration, when administered once daily in 21 day cycles, in male and female subjects with Multiple Myeloma. 2. To define objective response (ORR, CR, PR, MR, SD) and time to progression (TTP) of SRT501 in male and female subjects with Multiple Myeloma. 3. To define objective response (ORR, CR, PR, MR, SD) and time to progression (TTP) of SRT501 and bortezomib administered concurrently in male and female subjects with Multiple Myeloma. |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | No |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | No |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | No |
E.8.1.1 | Randomised | No |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | No |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 5 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 7 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | No |
E.8.6.2 | Trial being conducted completely outside of the EEA | Information not present in EudraCT |
E.8.7 | Trial has a data monitoring committee | No |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
| |
E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 1 |
E.8.9.1 | In the Member State concerned months | 2 |
E.8.9.1 | In the Member State concerned days | 0 |
E.8.9.2 | In all countries concerned by the trial years | 1 |
E.8.9.2 | In all countries concerned by the trial months | 2 |
E.8.9.2 | In all countries concerned by the trial days | 0 |