E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
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MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 9.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10002556 |
E.1.2 | Term | Ankylosing spondylitis |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
•To compare the efficacy of ARRY-371797 (200 mg q12h and 400 mg q24h) versus placebo in patients with active ankylosing spondylitis (AS). •To evaluate the safety of ARRY-371797 in patients with active AS.
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E.2.2 | Secondary objectives of the trial |
•To evaluate the exposure of ARRY-371797 and a metabolite (AR00333953) in plasma after the administration of ARRY-371797. •To evaluate the effect of two dose regimens of ARRY-371797 versus placebo on measures of disease activity. •To evaluate the pharmacodynamic effects of two dose regimens of ARRY-371797 on circulating levels of exploratory markers of disease activity
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
1. Has provided written informed consent and is willing to comply with scheduled visits, treatment plans, laboratory tests, and other trial procedures; 2. Is at least 18 years of age; 3. Diagnosed with ankylosing spondylitis according to the Modified New York Criteria (1984); 4. Total Back Pain Score measured by 10-point numerical rating scale (NRS) ≥ 4 at Screening and at Baseline; 5. Clinically active axial disease characterized by a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score ≥ 4 at Screening and at Baseline despite concurrent treatment with conventional therapy (e.g., NSAIDs, glucocorticoids or DMARDs); 6. Inadequate response to at least 2 weeks of continuous treatment with NSAIDs, or unable to receive ≥ 2 full weeks of continuous treatment with NSAIDs because of intolerance; 7.If previously treated with a biological agent must NOT have failed due to lack of efficacy, and has completed the following washouts (calculated from first dose of Study Drug): a. Within 4 weeks of first dose of Study Drug: etanercept (Enbrel®), anakinra (Kineret®); b. Within 8 weeks of first dose of Study Drug: infliximab (Remicade®), adalimumab (Humira®); 8. Has completed a 4-week washout period (calculated from first dose of Study Drug), if treated with any of the following therapies: a. Any experimental therapy (within or outside a clinical trial setting); b. Intramuscular or intravenous corticosteroids; c. Other—herbal medications; immunization with any live virus vaccination (e.g., FluMist®). 9. Patients may continue on stable background therapy for AS (doses should be stable for at least 4 weeks prior to the first dose of Study Drug) only if it is included in the following list: a. Non-investigational NSAIDs and/or COX-2 inhibitors; b. DMARDs—methotrexate (≤ 25 mg/week), sulfasalazine (≤ 3 gm/day), leflunomide (≤ 20 mg/day); c. Hydroxychloroquine (≤ 400 mg/day); d. Low-dose oral corticosteroids (≤ 10 mg prednisone or equivalent per day); e. Opioid analgesics (≤ 30 mg oral morphine or equivalent per day); f. Acetaminophen (paracetamol) ≤ 4000 mg/day (4 g/day); g. Aspirin if taken for non-arthritic reasons (≤ 325 mg/day). 10. If female participant, has met either criterion “a” or “b” below: a. Is of non-childbearing potential (amenorrheic for at least 2 years, or had a hysterectomy and/or bilateral oophorectomy at least 8 weeks prior to screening); • All other female patients (including those with tubal ligation) will be considered of childbearing potential. b. Is of childbearing potential and willing to use the acceptable methods of contraception and abide by the timelines of each method. 11. If male participant, must be willing to use the acceptable methods of contraception and abide by the timelines.
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E.4 | Principal exclusion criteria |
1. Diagnosis of any other active or uncontrolled inflammatory or non-inflammatory articular disease that may interfere with disease activity assessments; 2. Previously treated with IV immunoglobulins within 6 months of first dose of Study Drug; 3. History of: a. Significant renal, hepatic, hematological, gastrointestinal, endocrine, pulmonary, neurological or dermatological disease; b. Significant cardiac disease, myocardial infarction within 6 months of screening, unstable angina, congestive heart failure (New York Heart Association [NYHA] Class III-IV), known arrhythmias of ventricular etiology, unexplained syncope or syncope/seizures related to arrhythmia; c. Serious infection (defined as requiring parenteral antibiotics or hospitalization) within 6 months of first dose of Study Drug; d. Active tuberculosis or history of tuberculosis without documented curative treatment and/or positive tuberculin reaction to PPD (Purified Protein Derivative) without known vaccination with the Bacillus Calmette - Guerin vaccine (BCG). Prior history of BCG with positive reaction to PPD will require follow-up negative chest X-ray; e. Significant trauma or major surgery within 8 weeks of first dose of Study Drug; f. Alcohol abuse with less than 12 months of sobriety, or any drug abuse within 3 years of first dose of Study Drug; g. Cancer unless in complete curative remission for ≥ 5 years, excluding patients with adequately treated or excised nonmetastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ; h. Participation in another clinical trial within 4 weeks of Screening. 4. Presenting with any of the following: a. Severe psychological illness or any condition which will interfere with the patient’s ability to understand and/or comply with the requirements of the study; b. Any condition possibly affecting oral drug absorption (e.g., gastrectomy, malabsorption, Crohn’s disease or clinically significant diabetic gastroenteropathy); c. A documented body temperature ≥ 37.5˚C (99.5 ˚F) at Screening and Baseline (e.g., pre-dose on Day 1); d. An infection with human immunodeficiency virus (HIV) or hepatitis B or C; e. Any clinically significant active infection including herpes lesions; f. A confirmed mean of the screening triplicate QTc interval > 450 ms by Fridericia’s formula as calculated by the site. g. Total fusion of the spine 5. Evidence of organ dysfunction or hematopoietic disorder based on any of the following assessments at Screening: a. Hgb ≤ 10 g/dL or Hct ≤ 32%; b. Absolute WBC count ≤ 3.0 × 109/L (3000/mm3); c. Neutrophil count ≤ 1.2 × 109/L (1200/mm3); d. Platelet count ≤ 100 × 109/L (100,000/mm3); e. AST (aspartate aminotransaminase) or ALT (alanine aminotransaminase) ≥ 1.2 × upper limit of normal (ULN); f. Total bilirubin ≥ 1.5 × ULN; g. Alkaline phosphatase ≥ 1.5 × ULN; h. Albumin ≤ 3.5 g/dL (35 g/L); i. Serum creatinine ≥ 1.2 × ULN; j. Thyroid-stimulating hormone (TSH) ≥ 1.2 × ULN unless clinically euthyroid and receiving a stable dose of thryroxine. 6. Patients requiring prohibited concomitant medications including moderate or strong CYP3A inhibitors, CYP3A inducers and Biologic Response Modifiers (BRMs) while on study; 7. Pregnant or breastfeeding patients.
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E.5 End points |
E.5.1 | Primary end point(s) |
The primary endpoint will be ASAS 20 response at Week 12 |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | Yes |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | Yes |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | Yes |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | Yes |
E.8.1.5 | Parallel group | Yes |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | Yes |
E.8.1.7.1 | Other trial design description |
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E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | Yes |
E.8.2.3 | Other | No |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 12 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | Information not present in EudraCT |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
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E.8.7 | Trial has a data monitoring committee | No |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 1 |
E.8.9.1 | In the Member State concerned months | |
E.8.9.1 | In the Member State concerned days | |
E.8.9.2 | In all countries concerned by the trial years | 1 |