E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Asthma: Subjects with chronic inflammatory disorder of the airways characterized by recurrent episodes of wheezing, breathlessness, chest tightness, and coughing resulting from abnormal airflow obstruction and constriction |
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MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 12.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10003553 |
E.1.2 | Term | Asthma |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
The primary objective is to determine if AMG 827 is effective compared to placebo as measured by change in Asthma Control Questionnaire (ACQ) composite scores from baseline to week 12 |
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E.2.2 | Secondary objectives of the trial |
Evaluate the efficacy of AMG 827 as measured by: • Pre- and post-bronchodilator FEV1 (forced expiratory volume in 1 second), • AM and PM peak expiratory flow rate (PEFR), • Use of rescue short-acting β-agonist, • Daily symptoms (aggregate/night and individual symptoms; and symptom-free days) • Asthma quality life of questionnaire (AQLQ). Evaluate the pharmacokinetics of AMG 827 |
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E.2.3 | Trial contains a sub-study | Yes |
E.2.3.1 | Full title, date and version of each sub-study and their related objectives |
Pharmacokinetic Sampling Sub-study Biomarker Development Sub-study Pharmacogenetic Sub-study Sputum Sub-study |
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E.3 | Principal inclusion criteria |
- Men or women 18 to 65 years of age at the time of screening - Percent of predicted FEV1 ≥ 50% and ≤ 80% at screening and baseline visits - At least 12% reversibility over pre-bronchodilator FEV1 with SABA inhalation (up to 8 puffs) or nebulized equivalent (up to 2 treatments with 2.5 mg albuterol), demonstrated in the office during screening - Inhaled corticosteroid (ICS) ≥ 200 and ≤ 1000 μg/day fluticasone or equivalent. Stable ICS dose for ≥ 30 days before screening and must have used ICS for at least the last 3 consecutive months before screening. The ICS dose is expected to remain the same from screening through the end of study. - Ongoing asthma symptoms with ACQ composite score ≥ 1.5 points at screening and baseline - If receiving allergen immunotherapy, a stable dose for > 3 months before screening and anticipated to remain stable for the duration of the study - Nonsmoker or ex-smoker with < 10 pack-years (eg, 1 pack per day for 10 years) who stopped ≥ 1 year ago - Subject has a negative purified protein derivative (tuberculin) skin test within 6 weeks prior to randomization and has not been exposed to a person with active tuberculosis within 6 months of screening. Subjects with a known positive tuberculin skin test are allowed if: • They have completed treatment with appropriate chemoprophylaxis, or • They have a history of Bacillus Calmette-Guerin vaccination with a negative Quantiferon test - Subject or subject’s legally acceptable representative has provided informed consent, before any study specific procedure |
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E.4 | Principal exclusion criteria |
- Acute asthma exacerbation requiring emergency room treatment or hospitalization within 2 months of screening or any exacerbation between screening and baseline - Respiratory infection within 4 weeks of screening visit or 1 week of baseline visit - Any evidence of active infection at screening, during the run-in period or at the baseline visit requiring systemic antibiotics - History of endotracheal intubation for asthma-related exacerbation within 3 years of screening - History of chronic obstructive pulmonary disease or other chronic pulmonary condition other than asthma - Current diagnosis of sleep apnea with ongoing symptoms or requiring continuous positive airway pressure - History of aspirin-sensitive asthma - Any uncontrolled or clinically significant systemic disease (eg, uncontrolled diabetes, liver disease) - Any finding on the screening ECG that in the opinion of the investigator requires further cardiovascular evaluation - Poorly controlled hypertension defined as resting blood pressure > 150/90 mmHg (assessed on 2 separate occasions during the screening period) - Malignancy (other than resected cutaneous basal or cutaneous squamous cell carcinoma, or treated in situ cervical cancer considered cured) within 5 years of screening visit (if a malignancy occurred > 5 years ago, subject is eligible with documentation of disease-free state since treatment) - Known to have tested positive for hepatitis B virus surface antigen, hepatitis C virus antibody or human immunodeficiency virus |
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E.5 End points |
E.5.1 | Primary end point(s) |
Change in ACQ composite scores from baseline to week 12 |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | No |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | No |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | Yes |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | Yes |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | Yes |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | Yes |
E.8.2.3 | Other | No |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 3 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 31 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | Information not present in EudraCT |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
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E.8.7 | Trial has a data monitoring committee | No |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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The last clinical planned event for protocol-specified assessments supporting all planned analyses of the study |
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 1 |
E.8.9.1 | In the Member State concerned months | 6 |
E.8.9.1 | In the Member State concerned days | 0 |
E.8.9.2 | In all countries concerned by the trial years | 1 |
E.8.9.2 | In all countries concerned by the trial months | 6 |
E.8.9.2 | In all countries concerned by the trial days | 0 |