E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Age-related macular degeneration (AMD) |
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E.1.1.1 | Medical condition in easily understood language |
Neovascular age-related macular degeneration (also called wet AMD) |
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E.1.1.2 | Therapeutic area | Body processes [G] - Ocular Physiological Phenomena [G14] |
MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 14.0 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10025409 |
E.1.2 | Term | Macular degeneration |
E.1.2 | System Organ Class | 10015919 - Eye disorders |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
Primary Objectives:
• To assess the effect of pazopanib eye drops on central retinal thickness
• To evaluate the effect of pazopanib eye drops on visual acuity
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E.2.2 | Secondary objectives of the trial |
Secondary Objectives:
• To assess the effect of pazopanib eye drops on central retinal lesion thickness and retinal morphology
• To evaluate the safety and tolerability of pazopanib eye drops
• To determine steady-state plasma concentrations with topical ocular administration
Exploratory Objectives:
• To explore the relationship between plasma concentrations and the effect of pazopanib eyes drops on the reduction of retinal edema and improvements in visual acuity |
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
Subjects eligible for enrolment in the study must meet all of the following criteria:
1. Consent: Subject understands the procedures, agrees to participate in the study (including participation in the CFH Y402H pharmacogenetic research), and has signed and dated the informed consent form prior to the initiation of any study-related activities. If the subject is unable to read the consent form due to visual impairment then the consent must be read to the subject verbatim by the person administering the consent, a family member, or legally acceptable representative. (Note: Consent by legally acceptable representative is allowed where this is in accordance with local laws, regulations, and ethics committee policy.)
2. Age-related macular degeneration: For each subject enrolled in the study, only one eye (study eye) will be treated, and eligibility criteria apply to the study eye. All of the following characteristics are required and must be confirmed by the central reading center:
• CNV caused by AMD that extends under the geometric center of the foveal avascular zone
• Center subfield thickness (inclusive of subretinal fluid) > 320 microns on OCT [SPECTRALIS (Heidelberg)]
• Total lesion area 12 disc areas on fluorescein angiography, where the lesion complex includes CNV, blood, blocked fluorescence not from blood, and serous detachment of the retinal pigment epithelium
• CNV comprises 50% of lesion area
• classic CNV comprises < 50% of the lesion area
• fibrosis comprises ≤ 25% of lesion area
• if no evidence of classic CNV, then presumed to have recent disease progression based on deterioration ( 5 letter decrease in vision or evidence of growth of a CNV lesion on fluorescein angiography ) within the last 3 months or evidence of hemorrhage from CNV
3. Visual acuity: Best-corrected visual acuity score by electronic ETDRS in the study eye of between 25 and 73 letters (approximately equivalent to Snellen VA of 20/320 to 20/32) at screening
4. Gender and age: Subject is a male or female adult 50 years of age or older.
5. Non-childbearing potential: Female subject is of non-childbearing potential defined as being physiologically incapable of becoming pregnant. This includes any female who is post-menopausal (12 months of spontaneous amenorrhea) or who is surgically post-menopausal (via documented hysterectomy or bilateral tubal ligation). In questionable cases of postmenopausal status, a blood sample with simultaneous follicle stimulating hormone (FSH) >40 MIU/mL and estradiol <40 pg/mL (<140 pmol/L) [or equivalent values based on local laboratory criteria] is confirmatory. Refer to the SPM for more information.
6. Study Compliance: Subject is able and willing to comply with the study requirements and is able and willing to attend all scheduled visits.
7. Liver function tests: Subject has liver chemistry values that are within normal limits or clinically insignificant as evidenced by serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <2xULN; alkaline phosphatase and bilirubin <1.5xULN (isolated bilirubin >1.5xULN is acceptable, if bilirubin is fractionated and direct bilirubin is < 35%).
8. QT interval: Subject has a QTcF value < 450 msec, or < 480 msec for subjects with Bundle Branch Block. [Note: subjects with paced rhythms may be considered pending discussion with the medical monitor.]
Specific information regarding warnings, precautions, contraindications, adverse events, and other pertinent information on the GSK investigational product or other study treatment that may impact subject eligibility is provided in the Investigator Brochure for Ophthalmic Indications [UM2007/0007/04, 2010].
Deviations from inclusion criteria are not allowed because they can potentially jeopardize the scientific integrity of the study, regulatory acceptability or subject safety. Therefore, adherence to the criteria as specified in the protocol is essential. |
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E.4 | Principal exclusion criteria |
Subjects meeting any of the following criteria must not be enrolled in the study:
Study Eye:
1. Additional eye disease in the study eye that could compromise best-corrected visual acuity (e.g. glaucoma with documented visual field loss, clinically significant diabetic retinopathy, ischemic optic neuropathy, infection or retinitis pigmentosa)
2. CNV in the study eye due to other causes unrelated to age-related macular degeneration
3. Presence of retinal angiomatous proliferation (RAP) in the study eye, as determined by the investigator (confirmation by indocyanine green angiography is not required)
4. Geographic atrophy involving the center of the fovea in the study eye
5. Anterior segment and vitreous abnormalities in the study eye that would preclude adequate observation of the fundus for photographs, fluorescein angiography and spectral-domain OCT
6. Vitreous, subretinal or retinal hemorrhage in the study eye that is unrelated to AMD
7. Presence of an RPE tear in the study eye
8. Aphakia or total absence of the posterior capsule (Yttrium aluminum garnet (YAG) capsulotomy permitted) in the study eye
9. History of vitrectomy in the study eye
10. Intraocular surgery in the study eye within 3 months prior to treatment
11. Any previous treatment in the study eye for neovascular AMD, approved or investigational
Fellow Eye:
12. Current intravitreal anti-VEGF therapy in the fellow eye
13. Best-corrected visual acuity score by electronic ETDRS < 56 letters in the fellow eye at screening
Concurrent Conditions or Concomitant Medications:
14. Subject has uncontrolled glaucoma (intraocular pressure > 25 mmHg) despite treatment with anti-glaucoma medication.
15. A known, positive test for Hepatitis B surface antigen or Hepatitis C antibody within 3 months of screening
16. Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones)
17. Active bleeding disorder or a history of hemoptysis, cerebral or clinically significant gastrointestinal hemorrhage within 6 months of screening
18. Significant uncontrolled or unstable cardiovascular, nervous system, pulmonary, renal, endocrine, or gastrointestinal disease for example:
• Uncontrolled diabetes mellitus, with hemoglobin A1c (HbA1c) > 10%
• Myocardial infarction or stroke within 6 months of screening
• Major surgery within 3 months of screening
• Clinically relevant thyroid disease
19. Uncontrolled hypertension:
Systolic blood pressure > 160 mmHg
Diastolic blood pressure > 100 mmHg
Note: Initiation or adjustment of antihypertensive medications is permitted prior to study entry provided the referenced criteria are met (See Section 4.4.3).
20. Subject has a history within the past 2 years of alcohol or substance abuse, or psychiatric disorder likely to confound the efficacy or safety assessments.
21. Known HIV infection
22. Within 6 months prior to the Screening Visit, use of any systemically administered anti angiogenic agent (e.g., bevacizumab, sunitinib, cetuximab, sorafenib, pazopanib), approved or investigational
23. Within 6 months prior to the Screening Visit, use of medications known to be toxic to the retina, lens or optic nerve (e.g. desferoximine, chloroquine/hydrochloroquine, chlorpromazine, phenothiazines, tamoxifen, and ethambutol)
24. Use of systemic steroids (>10 mg prednisone or equivalent/day) within 14 days of the start of treatment
25. Use of prohibited medications within the restricted timeframe relative to the start of study medication (See Section 5.5.2)
26. Use of an investigational drug within 30 days of screening
27. History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation
28. A condition or situation, which, in the opinion of the investigator, may result in significant risk to the patient, confound the study results or interfere significantly with participation. |
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E.5 End points |
E.5.1 | Primary end point(s) |
• Change from baseline in central retinal thickness over time, as measured by OCT, and change from baseline in BCVA over time, as measured by the number of letters determined by EVA, with the changes after 28 days of treatment (Week 4 [Day 29] Visit) being the primary focus |
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E.5.1.1 | Timepoint(s) of evaluation of this end point |
Screening (days -8- to -2 before baseline) to Day 29. |
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E.5.2 | Secondary end point(s) |
OCT endpoints:
• Change from baseline in central retinal lesion thickness over time
• Change in intraretinal (IR) or subretinal (SR) fluid, intraretinal cysts, or serous retinal pigment epithelial detachment (PED) over time
Visual acuity endpoints:
• Visual acuity response over time (proportion of subjects with BCVA of various 5-letter thresholds gained or lost from baseline; proportion of subjects whose BCVA did not decline from baseline)
Fluorescein angiographic and fundus photographic endpoints:
• Change from baseline in the area of CNV
• Change from baseline in the area of the CNV lesion complex (i.e., CNV, blood, PED, and fibrosis)
Rescue endpoints:
• Proportion of patients who receive rescue treatment
• Time to rescue injection
Safety endpoints:
• Non-serious adverse events (AEs) and serious adverse events (SAEs) (both ocular and non-ocular AEs)
• Ocular assessments on general ophthalmic examination
• Vital signs
• Laboratory analytes including hematology and clinical chemistries
• Urinalysis
Pharmacokinetic endpoint:
• Plasma pazopanib concentrations
Exploratory endpoints:
• Pharmacokinetic endpoint: Response as related to plasma pazopanib concentration
• Pharmacogenetic endpoint: Response as related to the status of genetic polymorphisms including the CFH Y402H polymorphism |
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E.5.2.1 | Timepoint(s) of evaluation of this end point |
Screening (days -8- to -2 before baseline) to Day 29. |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | No |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | Yes |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | No |
E.8.1.1 | Randomised | No |
E.8.1.2 | Open | Yes |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | No |
E.8.2.3 | Other | No |
E.8.2.4 | Number of treatment arms in the trial | 1 |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 3 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 5 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | No |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
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E.8.7 | Trial has a data monitoring committee | No |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 0 |
E.8.9.1 | In the Member State concerned months | 2 |
E.8.9.1 | In the Member State concerned days | 14 |
E.8.9.2 | In all countries concerned by the trial years | 0 |
E.8.9.2 | In all countries concerned by the trial months | 2 |
E.8.9.2 | In all countries concerned by the trial days | 14 |