Applicable in all centres and concerned mainly: - Deletion of urinary proteinuria test; blood biochemistry testing was maintained to ensure detection of abnormality in renal dysfunction. - Reduce to one measurement, instead of three, of sitting blood pressure, considered as reliable enough in blood pressure assessment. - Change to one month before the selection of the patient, the planned period of 3 months without compression and for non-authorized pharmacological treatment. - Deletion of the detailed mention regarding Ankle Brachial Pressure Index for assessment of peripheral arterial occlusive disease. - Clarification of the definition and wording of following non-selection criteria: “on going deep or superficial vein thrombosis” and “Evidence of cancer”. - Precision regarding non-compliance (protocol deviation). - Deletion of the question 8a in CIVIQ-20 in accordance with Pr Launois (author of CIVIQ-20). Only the question 8b was taken in account for the questionnaire analysis for the study. Indeed, question 8a was restrictive to car use which was not common in all countries.