After 1.5 years of patient recruitment the scientific steering committee of the study evaluated the study and drew the conclusion that the study had to be terminated prematurely. This was based solely on futility, i.e. the committee could not see it possible to recruit sufficient number of patients in order to reach the goal of the study within a reasonable time frame. Further, an evaluation of involvement of other countries was done, but it was considered not possible to obtain the same local financial support as achieved in Scandinavia, and therefore, such an alternative was rejected. The discussion within the steering committee furthermore clarified that the reasons for futility was different among countries and regions. In Norway, a huge proportion of patients had already been converted to everolimus, whereas this situation was different in Denmark and Sweden. On the other hand, several patients in Denmark had actually declined participation, simply as they (presumably were pleased with their current medication and) did not wish to risk being converted. Due to the decision of prematurely terminate the study, all patients were taken in for a final study visit.