The originally submitted trial protocol (Version 1.0, dated 21 Oct 2014) was updated in response to objections made by the IEC. This updated version was submitted to the Competent Authority as substantial Amendment 1: • Inclusion criterion 1 and 3 were modified (extension of stable metformin therapy from 3 to 6 months and removal of the restriction that T2DM could have been diagnosed only within 3 months prior to screening) • Withdrawal criteria 5 and 6 were added to be able to withdraw subjects with severe hypoglycaemia or any other severe complication during the clamp procedure • Due to safety objections subjects were not released immediately after the clamp but kept for another 4 hours post-clamp for stabilization and control of blood glucose values.