E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Primary Ciliary Dyskinesia |
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E.1.1.1 | Medical condition in easily understood language |
Primary Ciliary Dyskinesia |
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E.1.1.2 | Therapeutic area | Diseases [C] - Respiratory Tract Diseases [C08] |
MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 20.0 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10069713 |
E.1.2 | Term | Primary ciliary dyskinesia |
E.1.2 | System Organ Class | 10010331 - Congenital, familial and genetic disorders |
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E.1.3 | Condition being studied is a rare disease | Yes |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
To evaluate the safety and efficacy of treatment with VX-371, administered with and without 4.2% hypertonic saline (HS) in subjects with primary ciliary dyskinesia (PCD) who are ≥12 years of age.
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E.2.2 | Secondary objectives of the trial |
To evaluate the effect of VX-371 on quality of life (QOL) in subjects with PCD |
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
Subjects who meet all of the following inclusion criteria will be eligible. 1. Subject (or subject’s legally appointed and authorized representative) will sign and date an informed consent form (ICF) and, where appropriate, assent form. 2. Willing and able to comply with scheduled visits, treatment plan, study restrictions laboratory tests, contraceptive guidelines, and other study procedures. 3. Willing and able to use the nebulization device as directed by the instructions for use. 4. Confirmed diagnosis of PCD based on the following: A. Subjects ≥12 to <18 years of age must meet 2 or more of the following PCD clinical criteria: ● Unexplained neonatal respiratory distress (at term birth) with need for respiratory support with CPAP and/or oxygen for >24 hours ● Any organ laterality defect confirmed by chest imaging – situs inversustotalis, situs ambiguous, or heterotaxy ● Daily, year-round wet or productive cough starting in first year of life or bronchiectasis on chest imaging ● Daily, year-round nasal congestion starting in first year of life or pansinusitis on sinus imaging B. Subjects ≥18 years of age must have bronchiectasis on chest imaging C. All subjects must ALSO have at least one of the following confirmatory tests: ● For patients with no laterality defect, nNO level during plateau <77 nL/min on 2 occasions, >2 weeks apart, with CF excluded by sweat chloride or genetic testing ● For patients with a laterality defect, nNO level during plateau <77 nL/min on at least 1 occasion ● Diagnostic ciliary ultrastructural defect on transmission electron micrograph ● Two loss of function and/or known mutations in a single PCD-associated gene. 5. Subjects with percent predicted FEV1 of ≥40 to <90 percentage points adjusted for age, sex, and height according to the Global Lung Initiative (GLI) at the Screening Visit, taken 4 hours or more after last dose of short-acting bronchodilators (β-agonists and/or anticholinergics) 6. Non-smoker for the past 90 days prior to the Screening Visit and less than a 5 pack-year lifetime history of smoking, and willing to not smoke while enrolled in the study. 7. Stable regimen of medications and chest physiotherapy for the 28 days prior to Day 1, and no anticipated need for changes during the study period (other than stopping inhaled HS). 8. If currently using daily inhaled HS, must be able to discontinue its use for the duration of the study. 9. If taking daily chronic or chronic cycling antibiotics, has been on a consistent regimen for at least 4 months prior to the Screening Visit. The cycling regimen of antibiotics can be either intermittent monotherapy (e.g., 28 days on/28 days off) or continuous alternating therapy (e.g., 28-day cycles of two antibiotics). 10. Clinically stable (as deemed by the investigator) for at least 14 days prior to the Screening Visit with no evidence of significant new or acute respiratory exacerbations, excluding symptoms of allergic (perennial or seasonal) or non-allergic rhinitis. 11. Female subjects of childbearing potential must have a negative serum pregnancy test at the Screening Visit. Females of childbearing potential must have a negative urine pregnancy test at the Day 1 and Day 57 visits before receiving the first dose of study drug in each Treatment Period, respectively. Subjects of childbearing potential and who are sexually active must meet the contraception requirements outlined in Section 11.6.5.1. |
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E.4 | Principal exclusion criteria |
Subjects who meet any of the following exclusion criteria will not be eligible. 1. Diagnosis of CF, including at least 1 of the following: a. Documented sweat chloride test ≥60 mM by quantitative pilocarpine iontophoresis or b. Abnormal nasal transepithelial potential difference (NPD) test or c. 2 CF-causing genetic mutations in the CFTR gene 2. Subjects with only 1 mutation in the CFTR gene and a sweat chloride test ≥60 mM by quantitative pilocarpine iontophoresis. 3. History of any organ transplantation or lung resection or chest wall surgery of such severity that it has an impact on pulmonary function. 4. Significant congenital heart defects, other than a laterality defect, at the discretion of the investigator. 5. Diagnosis of Cri du chat syndrome (chromosome 5p deletion syndrome). 6. Inability to withhold short-acting bronchodilator use for 4 hours prior to clinic visit. 7. History of any illness or any clinical condition that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug(s) to the subject. This may include, but is not limited to history of clinically significant and uncontrolled adrenal, neurologic, gastrointestinal, renal, hepatic, cardiovascular (including hyper/hypotension and tachy/bradycardia), psychological, pulmonary (other than PCD), metabolic, endocrine, or hematological disorder or disease, or scoliosis of such severity that it impacts pulmonary function or any other major disorder or disease, in the opinion of the investigator. 8. Used diuretics (including amiloride) or renin-angiotensin antihypertensive drugs (e.g., spironolactone, angiotensin converting enzyme [ACE] and/or neural endopeptidase (NEP)-inhibitors, or angiotensin receptor blockers [ARBs]) or trimethoprim or drospirenone in the 28 days before Day 1 or anticipate need for these medications during the study. 9. Had symptoms of acute upper or lower respiratory tract infection or had an acute pulmonary exacerbation requiring treatment or was treated with systemic antibiotics for ear or sinus disease within 14 days before Day 1 (topical otic antibiotics allowed). 10. History of significant intolerance to inhaled HS, or intolerance to the single dose of HS at the Screening Visit, as determined by the investigator. 11. History of drug or alcohol abuse, in the opinion of the investigator. 12. Known hypersensitivity to the study drug or amiloride. 13. Pregnant and/or nursing females. 14. Any clinically significant laboratory abnormalities at the Screening Visit as judged by the investigator, or any of the following: a. Plasma or serum potassium > central laboratory vendor upper limit of normal (ULN) b. Abnormal renal function, defined as creatinine clearance rate <60 mL/min using the Bedside Schwartz equation (for subjects 12 to17 years of age) or <50 mL/min using the Cockcroft-Gault equation (for subjects ≥18 years of age). c. Abnormal liver function, defined as ≥3 × ULN for alanine transaminase (ALT), or aspartate transaminase (AST), or >2 x ULN for total bilirubin, unless accounted for by Gilbert’s syndrome (benign indirect hyperbilirubinemia) d. Hemoglobin concentration <10.0 g/dL 15. Unwilling or unable to follow the contraception guidelines as outlined in Section 11.6.5.1. 16. History of at least two sputum or throat swab cultures yielding B. cepacia complex or M. abscessus or M. avium within the previous 2 years. 17. Has had surgery within 3 months of Day 1 that required general anesthesia and hospitalization. 18. Has previously participated in an investigational study involving administration of any investigational compound or use of an investigational device within 28 days prior to the Screening Visit (Note: Participation in a past or concurrent observational study is acceptable). 19. Has any surgical or medical condition which in the judgment of the investigator might interfere with the absorption, distribution, metabolism, or excretion of the study drug or with safety evaluations. 20. Is unable to maintain a stable dosage regimen of any concomitant medication throughout the duration of the study. 21. Has any other condition or circumstances that, in the opinion of the investigator, should disqualify this subject for this study. 22. The subject or a close relative of the subject is the investigator or a sub-investigator, research assistant, pharmacist, study coordinator, or other staff directly involved in the conduct of the study. |
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E.5 End points |
E.5.1 | Primary end point(s) |
-Results of safety and tolerability assessments of adverse events (AEs), clinical laboratory values (urine, serum and plasma chemistry, and hematology), 12-lead electrocardiograms (ECGs), spirometry, vital signs, and pulse oximetry. -Absolute change in percent predicted FEV1, from study baseline after 28 days of treatment. |
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E.5.1.1 | Timepoint(s) of evaluation of this end point |
For TP1 it will be evaluated at day 28 and for TP2 it will be evaluated at day 85 --> both compared to study baseline |
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E.5.2 | Secondary end point(s) |
-Change in QOL score as measured by the PCD Quality of Life Questionnaire (QOL-PCD) and the St. George’s Respiratory Questionnaire (SGRQ) after 28 days of treatment. |
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E.5.2.1 | Timepoint(s) of evaluation of this end point |
For TP1 it will be evaluated at day 28 and for TP2 it will be evaluated at day 85 --> both compared to study baseline |
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | No |
E.6.3 | Therapy | No |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | Yes |
E.6.6 | Pharmacokinetic | Yes |
E.6.7 | Pharmacodynamic | Yes |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | Yes |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | No |
E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | Yes |
E.7.3 | Therapeutic confirmatory (Phase III) | No |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | Yes |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | Yes |
E.8.1.5 | Parallel group | No |
E.8.1.6 | Cross over | Yes |
E.8.1.7 | Other | No |
E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | Yes |
E.8.2.3 | Other | No |
E.8.2.4 | Number of treatment arms in the trial | 4 |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 3 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 11 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | No |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
Belgium |
Canada |
Denmark |
Germany |
Italy |
Netherlands |
Poland |
Sweden |
United Kingdom |
United States |
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E.8.7 | Trial has a data monitoring committee | Yes |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 2 |
E.8.9.1 | In the Member State concerned months | 1 |
E.8.9.1 | In the Member State concerned days | 0 |
E.8.9.2 | In all countries concerned by the trial years | 2 |
E.8.9.2 | In all countries concerned by the trial months | 3 |
E.8.9.2 | In all countries concerned by the trial days | 0 |