E.1 Medical condition or disease under investigation |
E.1.1 | Medical condition(s) being investigated |
Respiratory syncytial virus infection |
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E.1.1.1 | Medical condition in easily understood language |
Respiratory syncytial virus infection is caused by RSV, which causes respiratory tract infections in people of all ages. |
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E.1.1.2 | Therapeutic area | Diseases [C] - Virus Diseases [C02] |
MedDRA Classification |
E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10035732 |
E.1.2 | Term | Pneumonia respiratory syncytial viral |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10038718 |
E.1.2 | Term | Respiratory syncytial virus bronchiolitis |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10069811 |
E.1.2 | Term | Respiratory syncytial virus bronchitis |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | PT |
E.1.2 | Classification code | 10061603 |
E.1.2 | Term | Respiratory syncytial virus infection |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10035692 |
E.1.2 | Term | Pneumonia due to respiratory syncytial virus |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10067384 |
E.1.2 | Term | Respiratory syncytial virus pneumonitis |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10052200 |
E.1.2 | Term | Respiratory syncytial virus infection NOS |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.2 Medical condition or disease under investigation |
E.1.2 | Version | 21.1 |
E.1.2 | Level | LLT |
E.1.2 | Classification code | 10066741 |
E.1.2 | Term | Respiratory syncytial virus infection recurrent |
E.1.2 | System Organ Class | 10021881 - Infections and infestations |
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E.1.3 | Condition being studied is a rare disease | No |
E.2 Objective of the trial |
E.2.1 | Main objective of the trial |
• To demonstrate the NI of the humoral immune response in healthy participants 50-59 YOA compared to OA (≥60 YOA) for the RSV-A strain after RSVPreF3 OA investigational vaccine administration. • To demonstrate the NI of the humoral immune response in healthy participants 50-59 YOA compared to OA (≥60 YOA) for the RSV-B strain after RSVPreF3 OA investigational vaccine administration. • To demonstrate the NI of the humoral immune response in participants 50-59 YOA at increased risk of RSV-LRTD compared to OA (≥60 YOA) for the RSV-A strain after RSVPreF3 OA investigational vaccine administration. • To demonstrate the NI of the humoral immune response in participants 50-59 YOA at increased risk of RSV-LRTD compared to OA (≥60 YOA) for the RSV-B strain after RSVPreF3 OA investigational vaccine administration.
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E.2.2 | Secondary objectives of the trial |
Safety: • To evaluate the safety and reactogenicity after the RSVPreF3 OA investigational vaccine administration. Immunogenicity: • To evaluate the humoral immune response to the RSVPreF3 OA investigational vaccine until 12 months post-study intervention administration. • To evaluate the cell-mediated immunity (CMI) response after RSVPreF3 OA investigational vaccine administration until 12 months post-study intervention administration. |
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E.2.3 | Trial contains a sub-study | No |
E.3 | Principal inclusion criteria |
• Participants who, in the opinion of the investigator, can and will comply with the requirements of the protocol • Written or witnessed informed consent obtained from the participant prior to performance of any study-specific procedure.
1. Specific inclusion criteria for all participants in Cohort 1 (Adults HA-RSV Group, Adults HA-Placebo Group, Adults AIR-RSV Group & Adults AIR-Placebo Group) • A male or female participant 50-59 YOA at the time of the study intervention administration. • Female participants of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as hysterectomy, bilateral oophorectomy, bilateral salpingectomy or post-menopause. • Female participants of childbearing potential may be enrolled in the study, if the participant: - has practiced adequate contraception from 1 month prior to study intervention administration until study end for this study, and - has a negative pregnancy test on the day of study intervention administration.
Specific inclusion criteria for participants in the Adults-HA Sub-cohort • Healthy participants as established by medical history and clinical examination before entering into the study. • Participants with chronic stable medical conditions with or without specific treatment, such as hypertension, hypercholesterolemia, or hypothyroidism, and who are not at increased risk for RSV-LRTD , are allowed to participate in this study if considered by the investigator as medically stable (no changes in the treatment or disease severity in the past 3 months).
Specific inclusion criteria for participants in the Adults-AIR Sub cohort Participants should be diagnosed with at least 1 of the following medical conditions and have a stable condition (no changes in the treatment or disease severity in the past 3 months): • Chronic pulmonary disease resulting in activity restricting symptoms or use of long-term medication • Chronic cardiovascular disease • Diabetes mellitus: types 1 and 2 • Other diseases at increased risk for RSV-LRTD disease - Chronic kidney disease - Chronic liver disease
2. Specific inclusion criteria for Cohort 2 (OA-RSV Group) • A male or female participant ≥60 YOA at the time of the study intervention administration. • Participants with chronic stable medical conditions with or without specific treatment, such as diabetes, hypertension or cardiac disease are allowed to participate in this study if considered by the investigator as medically stable (no changes in the treatment or disease severity in the past 3 months). • Participants living in the general community or in an assisted-living facility that provides minimal assistance, such that the participant is primarily responsible for self-care and activities of daily living. |
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E.4 | Principal exclusion criteria |
Medical conditions • Any confirmed or suspected immunosuppressive or immunodeficient condition resulting from disease or immunosuppressive/cytotoxic therapy , based on medical history and physical examination (no laboratory testing required). • History of any reaction or hypersensitivity likely to be exacerbated by any component of the study intervention. • Hypersensitivity to latex. • Unstable chronic illness. • Any history of dementia or any medical condition that moderately or severely impairs cognition. • Recurrent or uncontrolled neurological disorders or seizures. Participants with medically controlled active or chronic neurological diseases can be enrolled in the study as per investigator assessment, provided that their condition will allow them to comply with the requirements of the protocol. Study participants may decide to assign a caregiver to help them complete the study procedures. • Significant underlying illness that in the opinion of the investigator would be expected to prevent completion of the study. • Any medical condition that in the judgment of the investigator would make intramuscular injection unsafe. Prior/Concomitant therapy • Use of any investigational or non-registered product (drug, vaccine, or medical device) other than the study intervention during the period beginning 30 days before the dose of study intervention (Day -29 to Day 1), or planned use during the study period (up to Visit 4, Month 12). • Planned or actual administration of a vaccine not foreseen by the study protocol in the period starting 30 days before and ending 30 days after the dose of study intervention administration, with the exception of inactivated and subunit influenza vaccines or COVID-19 vaccines (fully licensed or with EUA) which can be administered up to 14 days before or from 14 days after the study intervention administration. Note: In case an emergency mass vaccination for an unforeseen public health threat is recommended and/or organized by the public health authorities, outside the routine immunization program, the time period described above can be reduced if necessary for that vaccine provided it is used according to the local governmental recommendations and that the Sponsor is notified accordingly. • Previous vaccination with an RSV vaccine, including investigational RSV vaccines. • Chronic administration of immune-modifying drugs (defined as more than 14 consecutive days in total) and/or administration of long-acting immune modifying treatments or planned administration at any time up to the end of the study. - Up to 3 months prior to the study intervention administration: o For corticosteroids, this will mean prednisone ≥20 mg/day, or equivalent. Inhaled and topical steroids are allowed. o Administration of immunoglobulins and/or any blood products or plasma derivatives. - Up to 6 months prior to study intervention administration: long-acting immune modifying drugs including among others immunotherapy (e.g., TNF-inhibitors), monoclonal antibodies, antitumoral medication. Prior/Concurrent clinical study experience • Concurrently participating in another clinical study, at any time during the study period, in which the participant has been or will be exposed to an investigational or a non-investigational vaccine/product (drug or invasive medical device).
Other exclusions Other exclusions for all participants • History of chronic alcohol consumption and/or drug abuse as deemed by the investigator to render the potential participant unable/unlikely to provide accurate safety reports or comply with study procedures. • Bedridden participants. • Planned move during the study period that will prohibit participating in the study until study end. • Participation of any study personnel or their immediate dependents, family, or household members.
Other exclusions for Cohort 1 • Pregnant or lactating female. • Female planning to become pregnant or planning to discontinue contraceptive precautions. |
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E.5 End points |
E.5.1 | Primary end point(s) |
1. RSV-A neutralization titers expressed as group geometric mean titer (GMT) ratio in healthy participants compared to OA 2. RSV-A neutralization titers expressed as group seroresponse rate (SRR) difference in healthy participants compared to OA 3. RSV-B neutralization titers expressed as group GMT ratio in healthy participants compared to OA 4. RSV-B neutralization titers expressed as group SRR difference in healthy participants compared to OA 5. RSV-A neutralization titers expressed as group GMT ratio in participants at increased risk of RSV-LRTD compared to OA 6. RSV-A neutralization titers expressed as group SRR difference in participants at increased risk of RSV-LRTD compared to OA 7. RSV-B neutralization titers expressed as group GMT ratio in participants at increased risk of RSV-LRTD compared to OA 8. RSV-B neutralization titers expressed as group SRR difference in participants at increased risk of RSV-LRTD compared to OA |
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E.5.1.1 | Timepoint(s) of evaluation of this end point |
1, 3, 5, 7. 1 month after the RSVPreF3 OA investigational vaccine administration (Day 31) 2, 4, 6, 8. 1 month after the RSVPreF3 OA investigational vaccine administration (Day 31) compared to baseline (Day 1) |
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E.5.2 | Secondary end point(s) |
1. Percentage of participants reporting each solicited administration site event (pain, redness and swelling) 2. Percentage of participants reporting each solicited systemic event (fever, headache, muscle pain, joint pain, tiredness) 3. Percentage of participants reporting unsolicited adverse events (AEs) 4. Percentage of participants reporting any serious adverse events (SAEs) 5. Percentage of participants reporting any potential immune mediated diseases (pIMDs) 6. Percentage of participants reporting SAEs related to study intervention administration 7. Percentage of participants reporting pIMDs related to study intervention administration 8. Percentage of participants reporting any fatal SAEs 9. RSV-A neutralization titers expressed as GMT 10. RSV-B neutralization titers expressed as GMT 11. Frequency of RSVPreF3-specific cluster of differentiation (CD)4+ T cells expressing at least 2 activation markers 12. Frequency of RSVPreF3-specific CD8+ T cells expressing at least 2 activation markers |
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E.5.2.1 | Timepoint(s) of evaluation of this end point |
1, 2. Within 4 days after study intervention administered on Day 1 3. Within 30 days after study intervention administered at Day 1 4, 5. After study intervention administration (Day 1) up to Month 6 6, 7, 8. After study intervention administration (Day 1) up to study end (Month 12) 9, 10, 11, 12. At pre-study intervention administration, 1 month, 6 months and at 12 months after study intervention administration
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E.6 and E.7 Scope of the trial |
E.6 | Scope of the trial |
E.6.1 | Diagnosis | No |
E.6.2 | Prophylaxis | Yes |
E.6.3 | Therapy | No |
E.6.4 | Safety | Yes |
E.6.5 | Efficacy | No |
E.6.6 | Pharmacokinetic | No |
E.6.7 | Pharmacodynamic | No |
E.6.8 | Bioequivalence | No |
E.6.9 | Dose response | No |
E.6.10 | Pharmacogenetic | No |
E.6.11 | Pharmacogenomic | No |
E.6.12 | Pharmacoeconomic | No |
E.6.13 | Others | Yes |
E.6.13.1 | Other scope of the trial description |
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E.7 | Trial type and phase |
E.7.1 | Human pharmacology (Phase I) | No |
E.7.1.1 | First administration to humans | No |
E.7.1.2 | Bioequivalence study | No |
E.7.1.3 | Other | No |
E.7.1.3.1 | Other trial type description | |
E.7.2 | Therapeutic exploratory (Phase II) | No |
E.7.3 | Therapeutic confirmatory (Phase III) | Yes |
E.7.4 | Therapeutic use (Phase IV) | No |
E.8 Design of the trial |
E.8.1 | Controlled | Yes |
E.8.1.1 | Randomised | Yes |
E.8.1.2 | Open | No |
E.8.1.3 | Single blind | No |
E.8.1.4 | Double blind | No |
E.8.1.5 | Parallel group | Yes |
E.8.1.6 | Cross over | No |
E.8.1.7 | Other | Yes |
E.8.1.7.1 | Other trial design description |
Observer-blind for Cohort 1 (Day1-Day 31), and single-blind afterwards, and open-label for Cohort 2 |
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E.8.2 | Comparator of controlled trial |
E.8.2.1 | Other medicinal product(s) | No |
E.8.2.2 | Placebo | Yes |
E.8.2.3 | Other | No |
E.8.2.4 | Number of treatment arms in the trial | 5 |
E.8.3 |
The trial involves single site in the Member State concerned
| No |
E.8.4 | The trial involves multiple sites in the Member State concerned | Yes |
E.8.4.1 | Number of sites anticipated in Member State concerned | 9 |
E.8.5 | The trial involves multiple Member States | Yes |
E.8.5.1 | Number of sites anticipated in the EEA | 27 |
E.8.6 Trial involving sites outside the EEA |
E.8.6.1 | Trial being conducted both within and outside the EEA | Yes |
E.8.6.2 | Trial being conducted completely outside of the EEA | No |
E.8.6.3 | If E.8.6.1 or E.8.6.2 are Yes, specify the regions in which trial sites are planned |
Argentina |
Canada |
Germany |
Japan |
Netherlands |
Poland |
Spain |
United States |
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E.8.7 | Trial has a data monitoring committee | No |
E.8.8 |
Definition of the end of the trial and justification where it is not the last
visit of the last subject undergoing the trial
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EoS: LSLV (Visit 4 at Month 12) or Date of the last testing/reading released of the Human Biological Samples, related to primary and secondary endpoints, whichever occurs later. EoS must be achieved no later than 8 months after LSLV. EoS cannot be before LSLV. |
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E.8.9 Initial estimate of the duration of the trial |
E.8.9.1 | In the Member State concerned years | 1 |
E.8.9.1 | In the Member State concerned months | 2 |
E.8.9.1 | In the Member State concerned days | 15 |
E.8.9.2 | In all countries concerned by the trial years | 1 |
E.8.9.2 | In all countries concerned by the trial months | 3 |
E.8.9.2 | In all countries concerned by the trial days | 17 |