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Clinical trials for Knee Arthroplasty

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    The EU Clinical Trials Register currently displays   44347   clinical trials with a EudraCT protocol, of which   7375   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    101 result(s) found for: Knee Arthroplasty. Displaying page 2 of 6.
    « Previous 1  2  3  4  5  6  Next»
    EudraCT Number: 2011-003556-39 Sponsor Protocol Number: DARINA Start Date*: 2012-06-05
    Sponsor Name:Martini Hospital Groningen
    Full Title: A randomized pilot study comparing the safety of DAbigatran and RIvaroxaban versus NAdroparin in the prevention of venous thromboembolism after knee arthroplasty surgery. DARINA
    Medical condition: After total knee arthroplasty (TKA) surgery, patients are at risk to develop venous thromboembolism (VTE). Two novel agents, dabigatran and rivaroxaban, recently gained market authorisation for pre...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003408-21 Sponsor Protocol Number: THO-IM_02-CT Start Date*: 2015-12-09
    Sponsor Name:Thrombotargets Europe
    Full Title: A Phase II/III, randomized, controlled, single blind study to evaluate the haemostatic efficacy and safety of topically applied TT-173 in patients undergoing knee arthroplasty
    Medical condition: Haemostatic effect in patients undergoing knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004865 10060663 Surgical hemostasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-000180-32 Sponsor Protocol Number: 761 Start Date*: 2017-02-10
    Sponsor Name:Sint Maartenskliniek Nijmegen
    Full Title: Pharmacokinetic Profile of Ropivacaine after Periarticular Local Infiltration Analgesia for Primary Total Knee Arthroplasty Without the use of a Tourniquet.
    Medical condition: patients receiving primary total knee replacement
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-001836-72 Sponsor Protocol Number: ISIS416858-CS3 Start Date*: 2013-01-11
    Sponsor Name:Isis Pharmaceuticals, Inc.
    Full Title: An Open-label, Randomized, Active Comparator-Controlled, Adaptive Parallel-group Phase 2 Study to Assess the Safety and Efficacy of Multiple Doses of ISIS 416858 Administered Subcutaneously to Pati...
    Medical condition: Prophylaxis of venous thromboembolism (VTE) in patients undergoing total knee arthroplasty (TKA)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004865 10049909 Venous thromboembolism prophylaxis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LV (Completed) BG (Completed)
    Trial results: View results
    EudraCT Number: 2005-000694-22 Sponsor Protocol Number: ACA-Germ-04-5 Start Date*: 2005-11-17
    Sponsor Name:Prof. Dr.Christian Werner
    Full Title: „Levobupivacaine for postoperative pain control in patients with knee arthroplasty – a comparison with ropivacaine“
    Medical condition: patients undergoing total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000071-24 Sponsor Protocol Number: TRANEXTIME Start Date*: 2016-03-10
    Sponsor Name:Consorci Mar Parc de Salut de Barcelona (Parc de Salut MAR)
    Full Title: TIME OF ADMINISTRATION OF TRANEXAMIC ACID TO PREVENT BLEEDING IN TOTAL KNEE ARTHROPLASTY
    Medical condition: Total knee arthroplasty bleeding
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-001232-59 Sponsor Protocol Number: AGO/2019/002 Start Date*: 2020-01-29
    Sponsor Name:Ghent University Hospital
    Full Title: Safety and Efficacy of Patient Controlled Analgesia using the Sublingual Sufentanil Tablet System (SSTS) in a fast track rehabilitation program after Total Knee Arthroplasty.
    Medical condition: Total Knee Arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    21.1 10042613 - Surgical and medical procedures 10036276 Postoperative analgesia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2022-001252-41 Sponsor Protocol Number: NA Start Date*: 2022-07-08
    Sponsor Name:CHU de Liège
    Full Title: Preventing postoperative anaemia in total knee arthroplasty and impact of intravenous iron supplementation on postoperative functional recovery : a randomized clinical trial
    Medical condition: Total Knee Arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-002438-35 Sponsor Protocol Number: 860 Start Date*: 2019-09-16
    Sponsor Name:Radboudumc [...]
    1. Radboudumc
    2. Sint Maartenskliniek
    Full Title: Multiple doses versus single dose of cefazolin to prevent periprosthetic joint infection after revision arthroplasty: a multicenter open-label, randomized clinical trial.
    Medical condition: Prevention of periprosthetic joint infection on patients undergoing revision surgery of the hip or knee.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10057129 Revision of total knee arthroplasty LLT
    20.0 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    20.0 10042613 - Surgical and medical procedures 10049924 Infection prophylaxis PT
    20.0 10042613 - Surgical and medical procedures 10064736 Antibiotic prophylaxis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-003695-31 Sponsor Protocol Number: FIB Start Date*: 2017-12-04
    Sponsor Name:Ziekenhuis Oost-Limburg
    Full Title: Fascia iliaca block for analgesia in unilateral direct anterior approach total hip arthroplasty
    Medical condition: Total hip arthroplasty through minimal invasive muscle sparing surgery technique
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10020096 Hip arthroplasty PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-002439-10 Sponsor Protocol Number: PAKA-33601-AS117013 Start Date*: 2013-10-23
    Sponsor Name:University of Warwick [...]
    1. University of Warwick
    2. University Hospitals Coventry & Warwickshire NHS Trust
    Full Title: Perioperative Analgesia for Knee Arthroplasty: A prospective randomised controlled trial
    Medical condition: Osteoarthritis of the knee is a common problem; it causes inability to walk without pain and a reduction in activity levels. Total knee replacements are performed for relief of this disabilitating ...
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001008-13 Sponsor Protocol Number: 497 Start Date*: 2013-09-18
    Sponsor Name:Sint Maartenskliniek
    Full Title: Fast-track rehabilitation protocol for Total Knee Arthroplasty: A Randomized Controlled Trial comparing Local Infiltration Analgesia with Femoral Nerve Block
    Medical condition: patients requiring total knee arthroplasty for non-inflammatory osteoarthritis of the knee
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2012-004046-15 Sponsor Protocol Number: TKA4 Start Date*: 2013-07-03
    Sponsor Name:ORtopædkirurgisk Forskningsenhed, Aarhus Universitetshospital
    Full Title: A 4-way randomized double-blinded migration (RSA), bone density (DXA), and biomarker study assessing adaptive bone changes and implant fixation and longevity of the new Regenerex Porous Titanium Ti...
    Medical condition: Osteoarthritis in the knee treated with cementless total knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004859 10023476 Knee osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-000082-23 Sponsor Protocol Number: 2016-001-M Start Date*: 2016-03-11
    Sponsor Name:Reinier de Graaf Groep
    Full Title: Median Local Anaesthetic Dose (MLAD) of intrathecal Bupivacaine in total knee arthroplasty
    Medical condition: Spinal anaesthesia during total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-001618-13 Sponsor Protocol Number: R475-OA-1816 Start Date*: 2018-11-28
    Sponsor Name:Regeneron Pharmaceuticals, Inc.
    Full Title: Study to Evaluate Arthroplasty Specimens in the Phase 3 Fasinumab Program for Osteoarthritis of the Knee and Hip
    Medical condition: Pain due to osteoarthritis of the knee or hip
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004859 10023476 Knee osteoarthritis LLT
    20.0 100000004859 10020108 Hips osteoarthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2022-000857-10 Sponsor Protocol Number: NA Start Date*: 2022-05-16
    Sponsor Name:CHU de Liège
    Full Title: Isobaric versus hyperbaric intrathecal bupivacaine: influence of baricity on blood pression variation during elective total knee arthroplasty: a randomized clinical trial.
    Medical condition: Total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-022701-17 Sponsor Protocol Number: 1709801154 Start Date*: 2015-11-17
    Sponsor Name:Isala
    Full Title: Reduction of surgical-site infection in hip and knee arthroplasty: the influence of perioperative mupirocin nasal ointment and chlorhexidine soap in a double-blind, randomized, multicentre, placebo...
    Medical condition: osteoarthritis of hip and knee, prevention of surgical site infections after arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-011492-73 Sponsor Protocol Number: 13.09 Start Date*: 2009-09-28
    Sponsor Name:Swindon and Marlborough NHS Foundation Trust
    Full Title: Analysis of Blood Loss With the Use of Fibrin Sealant in Total Knee Replacement Surgery – A Randomised Controlled Study
    Medical condition: Blood loss in total knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-003010-93 Sponsor Protocol Number: 620 Start Date*: 2014-10-15
    Sponsor Name:Sint Maartenskliniek
    Full Title: Pharmacokinetic Profile of Ropivacaïne after Periarticular Local Infiltration Analgesia for Primary Total Knee Arthroplasty
    Medical condition: patients receiving primary total knee replacement
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2006-001808-37 Sponsor Protocol Number: 612163 Start Date*: 2006-09-13
    Sponsor Name:Royal Devon and Exeter NHS Foundation Trust
    Full Title: A randomised controlled trial of fentanyl versus morphine following lower limb arthroplasty
    Medical condition: Patients with significant pain following hip or knee arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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