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Clinical trials for Physiological effect

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    409 result(s) found for: Physiological effect. Displaying page 2 of 21.
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    EudraCT Number: 2016-000532-17 Sponsor Protocol Number: Methylnaltrexone2016 Start Date*: 2016-06-09
    Sponsor Name:K.U. Leuven
    Full Title: Effect of methylnaltrexone on intragastric pressure, the occurrence of transient lower esophageal sphincter relaxations and reflux events in healthy subjects: a double-blind, placebo-controlled, ra...
    Medical condition: Impaired gastric accommodation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2014-000602-36 Sponsor Protocol Number: CRH2014 Start Date*: 2014-03-21
    Sponsor Name:KUleuven
    Full Title: The effect of corticotrophin-releasing hormone (CRH) on esophageal sensitivity in healthy volunteers: a randomized, single-blind, placebo-controlled study
    Medical condition: Changed esophageal sensitivity induced by CRH
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-004978-95 Sponsor Protocol Number: VildaMMC Start Date*: 2014-03-12
    Sponsor Name:KULeuven
    Full Title: the influence of a DPP-4 inhibitor, vildaglitpin, on hunger and the migrating motor complex in healthy volunteers
    Medical condition: healthy volunteers no medical condition, drug will be studied because they are known to influence gastric motility
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-006981-40 Sponsor Protocol Number: hypertension2006-006981-40 Start Date*: 2007-05-03
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust jointly with University of Cambridge
    Full Title: Does the underlying haemodynamic abnormality determine response to antihypertensive therapy in patients with hypertension?
    Medical condition: Essential hypertension
    Disease: Version SOC Term Classification Code Term Level
    9.1 10004254 Benign essential hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) EE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-000625-27 Sponsor Protocol Number: EAC01 Start Date*: 2021-06-11
    Sponsor Name:Oulu Functional NeuroImaging, MRC/MIPT, Oulu University Hospital
    Full Title: Augmenting glymphatic function with electroacoustic treatment.
    Medical condition: Investigated people are healthy adults.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000517-31 Sponsor Protocol Number: ANST_2014_KET Start Date*: 2014-06-10
    Sponsor Name:Leiden University Medical Center
    Full Title: Effect of perioperative ketamine on postoperative outcome – a randomized placebo-controlled trial
    Medical condition: Postoperative cognitive state
    Disease: Version SOC Term Classification Code Term Level
    17.0 10022117 - Injury, poisoning and procedural complications 10049987 Confusion postoperative PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-004852-52 Sponsor Protocol Number: OPHT-141117 Start Date*: 2018-04-17
    Sponsor Name:Medical University of Vienna, Department of Clinical Pharmacology
    Full Title: The effect of Tetrahydrocannabinol on ocular hemodynamics in healthy subjects
    Medical condition: The study will be carried out in healthy subjects.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-003409-86 Sponsor Protocol Number: Methnalox2012 Start Date*: 2012-10-09
    Sponsor Name:KULeuven
    Full Title: The effect of naloxone and methylnaltrexone on oesophageal sensitivity in healthy volunteers: a randomized, double-blind placebo controlled study.
    Medical condition: Altered oesophageal sensitivity
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-003912-23 Sponsor Protocol Number: ADX10059-202 Start Date*: 2006-10-26
    Sponsor Name:Addex Pharmaceuticals SA
    Full Title: A Phase IIa, double-blind, placebo-controlled, randomised, parallel-group study, to investigate the safety, tolerability and anxiolytic effect of the mGluR5 negative allosteric modulator ADX10059 i...
    Medical condition: Dental anxiety
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-004811-21 Sponsor Protocol Number: s53584 Start Date*: 2011-11-07
    Sponsor Name:UZLeuven
    Full Title: The effect of Sildenafil citrate (Viagra ®) on stomach motility, gastric emptying and food intake in healthy volunteers
    Medical condition: study is conducted on healthy volunteers, no medical condition is investigated
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2013-000026-57 Sponsor Protocol Number: Gra-sensv1 Start Date*: 2013-07-19
    Sponsor Name:Karolinska Institutet
    Full Title: Effect of granisetron on facial skin sensitivity in healthy volunteers
    Medical condition: Healthy and pain-free volunteers > 20 years of age, both sexes
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2013-004939-73 Sponsor Protocol Number: LINACLOTIDEPLACEBO Start Date*: 2014-05-13
    Sponsor Name:KULEUVEN
    Full Title: A RANDOMISED, PLACEBO-CONTROLLED, CROSSOVER STUDY TO EVALUATE THE EFFECT OF LINACLOTIDE ON COLONIC MOTILITY ASSESSED WITH INTRALUMINAL COLONIC MANOMETRY IN HEALTHY SUBJECTS
    Medical condition: COLONIC MOTILITY WILL BE STUDIED IN HEALTHY SUBJECTS
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003513-41 Sponsor Protocol Number: 15072011 Start Date*: 2011-10-27
    Sponsor Name:Danish Headache Center
    Full Title: A study of the farmacokinetic effect of telmisartan on the serum concentration of verapamil and the prophylactic effect of verapamil on clusterheadache.
    Medical condition: Horton's Headache
    Disease: Version SOC Term Classification Code Term Level
    14.1 10029205 - Nervous system disorders 10020397 Horton's headache LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-005452-26 Sponsor Protocol Number: SMR-2728 Start Date*: 2015-11-19
    Sponsor Name:OptiNose AS
    Full Title: A randomized, placebo controlled, double-blind, double-dummy, 3-period cross-over study in adult patients with autism spectrum disorders evaluating cognitive response, eye-gaze, and heart rate vari...
    Medical condition: Autism spectrum disorder
    Disease: Version SOC Term Classification Code Term Level
    17.1 10037175 - Psychiatric disorders 10063844 Autism spectrum disorder PT
    Population Age: Adults Gender: Male
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000037-36 Sponsor Protocol Number: KLF/K/010710 Start Date*: Information not available in EudraCT
    Sponsor Name:MCM Klosterfrau GmbH & Co. KG
    Full Title: Open label clinical trial to investigate the physiological effects on sleep of Nervenruh Baldrian Forte 600 in patients with primary insomnia
    Medical condition: Primary (psychophysiologic) insomnia
    Disease: Version SOC Term Classification Code Term Level
    13.1 10037175 - Psychiatric disorders 10036701 Primary insomnia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: View results
    EudraCT Number: 2012-003600-12 Sponsor Protocol Number: 12001 Start Date*: 2012-10-29
    Sponsor Name:Sportmedisch expertisecentrum
    Full Title: The effect of cold air on the airways of elite skaters and the protective role of the OMRON
    Medical condition: Exericise induced bronchoconstriction
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-003514-40 Sponsor Protocol Number: TromsøEndo-2013-1 Start Date*: 2013-09-17
    Sponsor Name:University Hospital of North Norway
    Full Title: The effect of vitamin D supplementation on cardiovascular risk factors in subjects with low serum 25-hydroxyvitamin D levels
    Medical condition: subjects with serum 25-hydroxyvitamin D < 35 nmol/L will be included and the effect of vitamin D supplementation versus placebo tested regarding cardiovascular risk factors
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000867-18 Sponsor Protocol Number: Codeine_I Start Date*: 2016-03-25
    Sponsor Name:KU Leuven
    Full Title: THE EFFECT OF CODEINE ON GASTRIC MOTILITY AS MEASURED WITH AN INTRAGASTRIC BALLOON
    Medical condition: gastroparesis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2013-004332-29 Sponsor Protocol Number: food_intake Start Date*: 2013-12-18
    Sponsor Name:UZLeuven
    Full Title: The influence of erythromycin and bitter administration on ad libitum food intake in healthy volunteers and patients
    Medical condition: The effect of erythromycin administration on voluntary food intake will be tested in healthy volunteers, obese patients and patients with unexplained weight loss
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-017193-20 Sponsor Protocol Number: S51994 Start Date*: 2010-01-28
    Sponsor Name:UZLeuven
    Full Title: Effect of naloxone and methylnaltrexone on satiety, gastric sensitivity, and accommodation to food in healthy volunteers.
    Medical condition: healthy volunteers none; this is a physiological study to investigate the influence of opioid antagonism on gastric sensorimotor function
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
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    Note, where multi-state trials are shown in search results, selecting "Full Trial details" will download full information for each of the member states/countries involved in the trial.
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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