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Clinical trials for Nervous System Diseases

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44393   clinical trials with a EudraCT protocol, of which   7405   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    2,629 result(s) found for: Nervous System Diseases. Displaying page 27 of 132.
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    EudraCT Number: 2020-005073-28 Sponsor Protocol Number: ParKMetil/001 Start Date*: 2021-12-28
    Sponsor Name:Universidad Rey Juan Carlos
    Full Title: Double-blind, randomized, crossover design for evaluation of efficacy and safety of methylphenidate in cognition in patients with Parkinson's disease using electrophysiological measures
    Medical condition: Cognition
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2020-005542-42 Sponsor Protocol Number: 2020/11 Start Date*: 2021-03-11
    Sponsor Name:Region Västerbotten
    Full Title: Intrathecal contrast-enhanced MRI for investigation of cerebrospinal fluid transportation
    Medical condition: Cerebrospinal fluid circulation disorder seen in clinically suspected idiopathic normal pressure hydrocephalus
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-004606-18 Sponsor Protocol Number: WASH-OUT Start Date*: 2018-06-19
    Sponsor Name:UNIVERSITÀ CAMPUS BIO-MEDICO DI ROMA
    Full Title: Terapia di disassuefazione con metilprednisolone e diazepam ev in pazienti affetti da cefalea cronica con uso eccessivo di sintomatici
    Medical condition: Emicrania Cronica e Cefalea da Iperuso di Farmaci
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004852 10066636 Chronic migraine LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000562-21 Sponsor Protocol Number: PI-001 Start Date*: 2015-01-07
    Sponsor Name:VU University Medical Center
    Full Title: Amyloid-PET as a diagnostic marker in daily practice.
    Medical condition: Unselected patient population subjects visiting the memory clinic of the VUmc Alzheimer center.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004846-28 Sponsor Protocol Number: NL60118.058.17 Start Date*: 2018-11-20
    Sponsor Name:Leiden University Medical Center
    Full Title: Efficacy of Sodium Oxybate to promote sleep in the ICU: A randomized controlled trial
    Medical condition: Sleep disturbance
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-000142-18 Sponsor Protocol Number: 1.0 Start Date*: 2018-05-09
    Sponsor Name:Turku University Hospital
    Full Title: Feasibility and pharmacodynamics of subcutaneously given combination of dexmedetomidine and ketamine infusion in ALS patients receiving palliative care
    Medical condition: Amyotrophic lateral sclerosis (ALS)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10036704 Primary lateral sclerosis LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001184-39 Sponsor Protocol Number: FBPASL5-01 Start Date*: 2015-09-17
    Sponsor Name:ASL 5 SPEZZINO
    Full Title: Assessing Florbetaben PET Patterns in MCI Patients for an Improved Prediction of Conversion to AD
    Medical condition: Mild Cognitive Impairment
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10009843 Cognitive deterioration LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001673-40 Sponsor Protocol Number: 2015/96 Start Date*: 2015-06-29
    Sponsor Name:Oslo University Hospital
    Full Title: INTRATHECAL CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING
    Medical condition: Cerebrospinal fluid circulation disorder seen in the following clinical disease states: Communicating hydrocephalus, idiopathic intracranial hypertension, idiopathic intracranial hypotension, intra...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-002566-13 Sponsor Protocol Number: NEXT-MS Start Date*: 2019-12-19
    Sponsor Name:Amsterdam University Medical Center
    Full Title: Personalized extended interval dosing of natalizumab in relapsing remitting multiple sclerosis
    Medical condition: Relapsing remitting multiple sclerosis
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10070425 Multiple sclerosis exacerbation LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-001285-11 Sponsor Protocol Number: P20.XXX Start Date*: 2021-01-12
    Sponsor Name:Leiden University Medical Center
    Full Title: A Randomized, open label, Non-inferiority trial on the efficacy of Lacosamide versus Duloxetine in Patients with Chemotherapy-induced Polyneuropathy – A strategy trial
    Medical condition: Chemotherapy-induced polyneuropathy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-006687-25 Sponsor Protocol Number: 79665 Start Date*: 2022-07-21
    Sponsor Name:Leiden University Medical Centre
    Full Title: Repeated corticosteroid injections around the Greater Occipital Nerve (GON) as prophylactic treatment in chronic cluster headache
    Medical condition: Chronic Cluster headache
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-004008-46 Sponsor Protocol Number: FFA-LGS Start Date*: 2016-01-07
    Sponsor Name:UZ Leuven
    Full Title: Add-on fenfluramine in Lennox Gastaut epilepsy
    Medical condition: Lennox Gastaut Epilepsy
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2015-002096-14 Sponsor Protocol Number: MF115 Start Date*: 2015-08-28
    Sponsor Name:Sahlgrenska University Hospital
    Full Title: Examine whether treatment with methylphenidate facilitates work rehabilitation for persons with long-term pain and mental fatigue after traumatic brain injury.
    Medical condition: Long-term pain and mental fatigue after traumatic brain injury and work rehabilitation.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-002481-32 Sponsor Protocol Number: InflamAD Start Date*: 2023-04-11
    Sponsor Name:Amsterdam UMC VUmc
    Full Title: Imaging inflammation in Alzheimer's Disease
    Medical condition: Amyloid-beta positive individuals across the Alzheimer's disease continuum and amyloid-beta negative individuals without cognitive complaints
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-003598-41 Sponsor Protocol Number: FRDA-GLP1-2014 Start Date*: 2014-10-02
    Sponsor Name:CUB - Hôpital Erasme
    Full Title: Pilot study of incretin analogs as new therapeutics for Friedreich's Ataxia.
    Medical condition: Friedreich's Ataxia
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003905-25 Sponsor Protocol Number: HAC2018-001 Start Date*: 2019-06-27
    Sponsor Name:H.A.C. Pharma
    Full Title: Evaluation of efficacy and tolerance of fludrocortisone (Flucortac) in the treatment of neurogenic orthostatic hypotension
    Medical condition: Neurogenic Orthostatic Hypotension (NOH)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10047065 - Vascular disorders 10031127 Orthostatic hypotension PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2014-000219-15 Sponsor Protocol Number: 13-10 Start Date*: 2014-11-27
    Sponsor Name:VU Medical Center
    Full Title: Amyloid pathology in cognitively normal elderly subjects
    Medical condition: Cognitively healthy elderly, aged 60-100 years old.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2018-004466-34 Sponsor Protocol Number: 18-07 Start Date*: 2019-05-16
    Sponsor Name:Amsterdam UMC VUmc
    Full Title: Tau PET imaging in cognitively normal elderly subjects: A twin approach
    Medical condition: Cognitively healthy elderly, aged 60-100 years old.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2020-002511-22 Sponsor Protocol Number: 20-05 Start Date*: 2023-06-08
    Sponsor Name:Amsterdam UMC VUmc
    Full Title: Synaptic density and tau pathology in Alzheimer's disease
    Medical condition: Amyloid-beta positive individuals across the Alzheimer's disease continuum
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-002180-33 Sponsor Protocol Number: SMderpept Start Date*: 2016-11-16
    Sponsor Name:Centrum Neurologii Krzysztof Selmaj
    Full Title: Multiple sclerosis therapy with transdermal myelin peptide stimulation.
    Medical condition: relapsing-remitting multiple sclerosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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