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Clinical trials for Surgery

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44344   clinical trials with a EudraCT protocol, of which   7373   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    5,833 result(s) found for: Surgery. Displaying page 3 of 292.
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    EudraCT Number: 2007-002223-32 Sponsor Protocol Number: E2007-0507 Start Date*: Information not available in EudraCT
    Sponsor Name:Charité Universitaetsmedizin
    Full Title: A multicentre, double-blind, randomised placebo-controlled trial of sodium bicarbonate to prevent acute kidney injury in patients undergoing cardiopulmonary bypass surgery.
    Medical condition: Cardiac surgical patients in whom the use of cardiopulmonary bypass is planned and having at least one ore more of the following risk factors for post-operative acute kidney injury • Age ≥ 70 years...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) IE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-003944-23 Sponsor Protocol Number: UFK-HEF 5 Start Date*: 2005-04-20
    Sponsor Name:Medical University of Vienna
    Full Title: Acetyl salicylic acid in the treatment of patients with positive margins after surgery for cervical dysplasia grade II-III: A phase II trial
    Medical condition: Cervical intraepithelial neoplasia grade II/III with positive margin after surgery
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2018-001485-42 Sponsor Protocol Number: NL65290.091.18 Start Date*: 2018-06-14
    Sponsor Name:Radboudumc
    Full Title: RECOVER study: the effect of low- versus normal pressure pneumoperitoneum during laparoscopic colorectal surgery on the early quality of recovery with perioperative care according to the enhanced r...
    Medical condition: Laparoscopic colorectal surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002208-14 Sponsor Protocol Number: Protocol v.1.2 30/08/04 Start Date*: 2005-02-21
    Sponsor Name:Cardiff and Vale NHS Trust
    Full Title: Duration of Amiodarone therapy required for new post cardiac surgery atrial fibrillation.
    Medical condition: Atrial fibrillation following cardiac surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2016-002016-40 Sponsor Protocol Number: ABR-57785 Start Date*: 2017-03-01
    Sponsor Name:Radboudumc
    Full Title: Neuroinflammation in cognitive decline post-cardiac surgery: the FOCUS study
    Medical condition: Neuroinflammation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2014-004313-82 Sponsor Protocol Number: 30-09-2014 Start Date*: 2015-02-03
    Sponsor Name:Anaesthesia and Operative Services, Kuopio University Hospital
    Full Title: Efficacy and safety of epidural oxycodone
    Medical condition: Acute postoperative pain after gynaecologic surgery.
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FI (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-000791-15 Sponsor Protocol Number: 1308015 Start Date*: 2013-08-08
    Sponsor Name:CHU de Saint-Etienne
    Full Title: Evaluation of postoperative administration of tranexamic acid on reducing blood loss after hip prothesis surgery.
    Medical condition: surgery for hip prosthesis or for hip prosthesis replacement
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004865 10044088 Total hip replacement LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2009-014414-98 Sponsor Protocol Number: 58185 Start Date*: 2009-10-29
    Sponsor Name:Department of Orthopaedic Surgery University Hospital Linköping
    Full Title: The impact of local bisphosphonate treatment on prosthetic fixation
    Medical condition: Osteoarthritis of the hip joint treated with total hip replacement
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-009986-32 Sponsor Protocol Number: OZR-2008-12 Start Date*: 2009-06-30
    Sponsor Name:Rotterdam Eye Hospital
    Full Title: Continuation of platelet inhibiting drugs in eyelid surgery. A randomized, double-masked, placebo-controlled clinical trial.
    Medical condition: Patients, using platelet inhibiting drugs, due for eyelid surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2010-018321-20 Sponsor Protocol Number: LIDOTAP Start Date*: 2015-11-04
    Sponsor Name:
    Full Title: Transversus abdominis plane block, intravenous lignocaine or placebo for postoperative analgesia after open prostate surgery: a randomized controlled trial
    Medical condition: Prostate surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003154-32 Sponsor Protocol Number: N/A Start Date*: 2017-09-18
    Sponsor Name:University of Leeds
    Full Title: SPAARK: Study of Peri-Articular Anaesthetic for Replacement of the Knee. The clinical and cost effectiveness of peri-articular liposomal bupivacaine compared with bupivacaine hydrochloride alone fo...
    Medical condition: Local anaesthetic for patients undergoing knee replacement surgery for arthritis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2020-005985-33 Sponsor Protocol Number: 402-C-319 Start Date*: 2020-12-16
    Sponsor Name:Pacira Pharmaceuticals, Inc.
    Full Title: A Multicenter Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postsurgical Analgesia in Pediatric Subjects Aged 6 to Less Than 17 Years
    Medical condition: Postsurgical pain
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2013-005473-52 Sponsor Protocol Number: 40964 Start Date*: 2014-04-24
    Sponsor Name:Hospital of South West Jutland
    Full Title: Prevention of bleeding and edema in bi-maxillary orthognathic surgery; the effectiveness of tranexamic acid on intraoperative bleeding in orthognathic surgery
    Medical condition: Surgical bleeding during bi-maxillary orthognathic surgery
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10051536 Intraoperative bleeding LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2021-003172-13 Sponsor Protocol Number: MERCURI Start Date*: 2021-10-14
    Sponsor Name:Amsterdam UMC
    Full Title: The renal and metabolic outcomes after sodium-glucose cotransporter 2 inhibitor in cardiac surgery – an open-label phase IV randomized controlled trial
    Medical condition: Cardiac surgery-associated acute kidney injury
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004857 10080266 Stage 1 acute kidney injury LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001693-15 Sponsor Protocol Number: IPPCollapse-II Start Date*: 2016-08-08
    Sponsor Name:INSTITUTO DE INVESTIGACIÓN SANITARIA LA FE
    Full Title: Individualized Pneumoperitoneum Pressure in Colorectal laparoscopic surgery versus standard therapy (IPPCollapse II)
    Medical condition: Pneumoperitoneum Pressure in Colorectal laparoscopic surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2019-001478-27 Sponsor Protocol Number: IRFMN-GCC-7813 Start Date*: 2019-09-11
    Sponsor Name:Associazione Chirurghi Ospedalieri Italiani
    Full Title: Prophylactic surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC CO2) versus standard surgery in gastric carcinoma at high risk of peritoneal carcinomatosis. Short and long-term outcomes....
    Medical condition: Patients with gastric carcinoma at high risk of developing peritoneal carcinomatosis, suitable to radical surgery.
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004864 10007350 Carcinoma gastric LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-004295-22 Sponsor Protocol Number: NL59645.098.16 Start Date*: 2017-04-10
    Sponsor Name:Hagaziekenhuis
    Full Title: Treatment of thromBocytopenia with EltRombopag or Intravenous Immune Globulin (IVIG) Before and DurING Invasive Procedures in Patients with Immune ThrombocytoPenia.
    Medical condition: Immune thrombocytopenia patients with low platelets and in need of surgery.
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004851 10023095 ITP LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001373-33 Sponsor Protocol Number: 2016-3 Start Date*: 2017-02-17
    Sponsor Name:Region Ostergotland
    Full Title: Clinical Study Protocol An open phase IV,RCT, evaluating patient controlled sedation, in three different dosages of propofol in healthy subjects undergoing elective gynaecological out-patient su...
    Medical condition: Gynecological outpatient surgery
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004612-31 Sponsor Protocol Number: BI3023_2002 Start Date*: 2008-05-29
    Sponsor Name:CSL Behring GmbH
    Full Title: Efficacy and safety of Haemocomplettan® P in patients experiencing acute bleeding while undergoing aortic replacement surgery
    Medical condition: Acute bleeding while undergoing aortic replacement surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10061651 Aortic surgery LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003293-93 Sponsor Protocol Number: 14072011 Start Date*: 2011-09-23
    Sponsor Name:Sint Antonius Ziekenhuis
    Full Title: Cyp3A4 metabolism before and after surgery induced weight loss in morbidly obese patients, using midazolam as a model drug
    Medical condition: Morbid obesity
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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