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Clinical trials for Opioid

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    593 result(s) found for: Opioid. Displaying page 6 of 30.
    «« First « Previous 2  3  4  5  6  7  8  9  10  Next» Last»»
    EudraCT Number: 2010-022991-29 Sponsor Protocol Number: SMR/0211OBD-1033 Start Date*: 2011-02-01
    Sponsor Name:Sucampo Pharma Americas, Inc.
    Full Title: A Multicenter, Randomized, Placebo-controlled, Double-blinded Study of the Efficacy and Safety of Lubiprostone in Patients with Opioid-induced Bowel Dysfunction
    Medical condition: Opioid-induced Bowel Dysfunction
    Disease: Version SOC Term Classification Code Term Level
    14.0 10017947 - Gastrointestinal disorders 10061247 Intestinal functional disorder PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) BE (Completed) SE (Completed) CZ (Completed)
    Trial results: View results
    EudraCT Number: 2008-005181-31 Sponsor Protocol Number: A4091003 Start Date*: 2009-04-29
    Sponsor Name:Pfizer Inc., 235 East 42nd Street, New York, NY 10017
    Full Title: PHASE II RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTICENTER EFFICACY AND SAFETY STUDY OF TANEZUMAB AS ADD-ON THERAPY TO OPIOID MEDICATION IN PATIENTS WITH PAIN DUE TO BONE METASTASES
    Medical condition: PAIN DUE TO BONE METASTASES
    Disease: Version SOC Term Classification Code Term Level
    9.1 10049038 Metastatic bone pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) LV (Completed) SK (Completed) FR (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2006-002414-35 Sponsor Protocol Number: 3200A3-200-WW Start Date*: 2006-11-02
    Sponsor Name:Wyeth Research Division of Wyeth Pharmaceuticals Inc.
    Full Title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects with Chronic Non-Malignant Pain.
    Medical condition: Opioid induced bowel dysfunction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) DE (Completed) NL (Completed) DK (Completed) GB (Completed) SE (Completed)
    Trial results: View results
    EudraCT Number: 2006-005403-34 Sponsor Protocol Number: CP045/06/FCNS Start Date*: 2007-02-01
    Sponsor Name:Archimedes Development Ltd
    Full Title: An open-label study investigating long-term safety and tolerability of Nasalfent (Fentanyl Citrate Nasal Spray) in the treatment of breakthrough cancer pain (BTCP) in subjects taking regular opioid...
    Medical condition: The treatment of Breakthrough Cancer Pain (BTCP) in subjects taking regular opioid therapy.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10058019 Cancer pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) NL (Completed) DE (Completed) CZ (Completed) ES (Ongoing) FR (Completed) IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-005922-62 Sponsor Protocol Number: OXN2501 Start Date*: 2008-05-22
    Sponsor Name:Mundipharma Research GmbH & Co. KG
    Full Title: An exploratory, randomised, active-controlled, double-blind, double-dummy, parallel group pilot study to determine the ability of oxycodone/naloxone prolonged release tablets (OXN) to reduce the nu...
    Medical condition: Opioid induced constipation
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021175 Iatrogenic constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) CZ (Completed) HU (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2006-005234-21 Sponsor Protocol Number: P04843 Start Date*: 2007-11-28
    Sponsor Name:Schering-Plough Research Institute
    Full Title: A Randomized Acceptability and Safety Study of the Transfer From Subutex to Suboxone in Opioid-Dependent Subjects.
    Medical condition: Opioid dependance
    Disease: Version SOC Term Classification Code Term Level
    9.1 10013663 Drug dependence LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) GB (Completed) SE (Completed) PT (Completed) DK (Completed) LT (Completed) SI (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2017-002078-38 Sponsor Protocol Number: SU/2016/6033 Start Date*: 2017-12-06
    Sponsor Name:University Hospitals Bristol NHS Foundation Trust
    Full Title: Effectiveness, cost effectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: A placebo controlled randomised controlled trial with blind...
    Medical condition: Post surgery pain management
    Disease: Version SOC Term Classification Code Term Level
    20.0 10042613 - Surgical and medical procedures 10036237 Post operative analgesia LLT
    20.0 10042613 - Surgical and medical procedures 10056350 Pain management PT
    20.0 100000004863 10036286 Post-operative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-003343-35 Sponsor Protocol Number: CR-TFB-2014/502 Start Date*: 2014-10-01
    Sponsor Name:Thomas Fichtner Bendtsen
    Full Title: The effect of saphenous nerve and obturator nerve block combined with systemic high dose glucocorticoid versus local infiltration analgesia combined with a systemic high dose glucocorticoid on opi...
    Medical condition: The medical condition to be examined in this study is the first postoperative period after total knee replacement with a view to pain management.
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004865 10038286 Regional nerve block LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-002237-11 Sponsor Protocol Number: ARC Start Date*: 2012-12-17
    Sponsor Name:King's College London [...]
    1. King's College London
    2. South London and Maudsley NHS Foundation Trust
    Full Title: Effectiveness of Adaptive Opioid Agonist Maintenance Pharmacotherapy and Behavioural Therapy for Opioid Use Disorder.
    Medical condition: Opiate dependency disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-005028-10 Sponsor Protocol Number: FARM7PER7 Start Date*: 2008-10-14
    Sponsor Name:Universita' di Firenze; Dipartimento di Farmacologia Preclinica e Clinica
    Full Title: Methadone dose adjustments, plasma R-methadone levels and therapeutic outcome of opioid addiction
    Medical condition: Heroin dependence
    Disease: Version SOC Term Classification Code Term Level
    9.1 10029205 Nervous system disorders SOC
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-004706-18 Sponsor Protocol Number: 269864 Start Date*: 2018-05-07
    Sponsor Name:Akershus University Hospital
    Full Title: Long acting naltrexone for opioid addiction: the importance of mental, physical and societal factors for sustained abstinence and recovery (NaltRec)
    Medical condition: Opioid addiction
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-002292-27 Sponsor Protocol Number: NonOnco2008 Start Date*: 2008-06-23
    Sponsor Name:OSPEDALE POLICLINICO S. MATTEO
    Full Title: Long term opioid administration in no-oncologic chronic pain: open label, prospective study on efficacy, safety and pharmacokinetic factors
    Medical condition: chronic pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-002273-12 Sponsor Protocol Number: Onco2008 Start Date*: 2008-06-23
    Sponsor Name:OSPEDALE POLICLINICO S. MATTEO
    Full Title: Long term opioid administration in oncologic chronic pain: open label, prospective study on efficacy, safety and pharmacogenetic factors.
    Medical condition: oncologic chronic pain
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-002148-17 Sponsor Protocol Number: ORKA Start Date*: 2016-08-24
    Sponsor Name:LUMC
    Full Title: Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers – the ORKA trial
    Medical condition: Respiratory depression
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004855 10069144 Acute respiratory insufficiency LLT
    19.0 100000004855 10038701 Respiratory insufficiency LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-014892-31 Sponsor Protocol Number: MAIVECMOPAIN Start Date*: 2009-11-10
    Sponsor Name:ErasmusMC - Sophia
    Full Title: Morphine intravenous vs. Paracetamol intravenous in children on ECMO
    Medical condition: Patients treated with Extra Corporal Membrane Oxygenation (ECMO) receive morphine as standardised analgesic drug. Morphine is associated with several side effects. In these patients a non-opioid dr...
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-004274-10 Sponsor Protocol Number: Etoric-TE-1 Start Date*: 2008-06-16
    Sponsor Name:Freistaat Bayern
    Full Title: Analgesic efficacy and safety of etoricoxib in ear nose throat surgery
    Medical condition: The aim of this study is to test the analgesic efficacy and safety of etoricoxib (90 mg or 120 mg qd. perioperatively) for post-operative pain relief in tonsillectomy patients.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10044006 Tonsillectomy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-007877-22 Sponsor Protocol Number: 2007IC013H Start Date*: 2008-07-10
    Sponsor Name:Royal Brompton & Harefield NHS Trust
    Full Title: A prospective blinded randomised placebo controlled trial investigating whether oxycodone modified release reduces parenteral opioid use following intermediate thoracic surgery
    Medical condition: The management of acute pain after intermediate thoracic surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10066714 Acute pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-003256-29 Sponsor Protocol Number: MNX2008 Start Date*: 2009-06-17
    Sponsor Name:Charité – Universitätsmedizin Berlin
    Full Title: Effect of Methylnaltrexone on Postoperative Analgesic Demands
    Medical condition: Pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2013-005201-31 Sponsor Protocol Number: INNalox-1 Start Date*: 2015-03-31
    Sponsor Name:Karolinska University Hospital
    Full Title: Pharmacokinetic profile and pharmacodynamic effects after intranasal naloxone administration in volunteers and pediatric patients.
    Medical condition: Sedation after opioid administration Pharmacokinetic profile after naloxone administered intranasally
    Disease:
    Population Age: Infants and toddlers, Children, Under 18, Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2012-000130-19 Sponsor Protocol Number: PHANOS2012 Start Date*: 2012-08-30
    Sponsor Name:Medizinische Universität Graz, Univ. Klinik für Anästhesiologie und Intensivmedizin, Abt. Anästhesie und Intensivmedizin
    Full Title: PHANOS (PHysostigmine-enHAnced Opioid analgeSia) study
    Medical condition: Postoperative pain
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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