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Clinical trials for Caffeine

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    81 result(s) found for: Caffeine. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2005-000408-16 Sponsor Protocol Number: HS-PM-013 Start Date*: 2005-04-05
    Sponsor Name:Karolinska University Hospital, Huddinge
    Full Title: Caffeine-mediated modulation of human experimental pain models
    Medical condition: Healthy human volunteer subjects
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-005568-24 Sponsor Protocol Number: NL47657-044-14 Start Date*: 2014-05-28
    Sponsor Name:Medisch Spectrum Twente
    Full Title: The reduction of Apneas in Preterm Infants: Low-Flow versus Caffeine
    Medical condition: Apnea Of Prematurity
    Disease:
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-003274-32 Sponsor Protocol Number: 2015/233 Start Date*: 2016-07-13
    Sponsor Name:Dra Maria Luz Couce [...]
    1. Dra Maria Luz Couce
    2. Dr. José Luis Fernández Trisac
    Full Title: Effect of caffeine citrate in acute bronchiolitis symptoms of apnea in neonates and infants during the first three months of life
    Medical condition: Children under 3 years with acute RSV bronchiolitis which present breaks apnea
    Disease:
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-003513-33 Sponsor Protocol Number: 21069 Start Date*: 2020-05-20
    Sponsor Name:Bayer HealthCare LLC
    Full Title: A Randomized, Double-Blind, Single-Dose, Parallel, Placebo-Controlled Trial to Determine the Dose of Caffeine in a Fixed Dose Combination Tablet of Naproxen Sodium and Caffeine to Effectively Allev...
    Medical condition: Pain, Postoperative
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10054711 Postoperative pain LLT
    20.0 10042613 - Surgical and medical procedures 10061812 Dental operation PT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2006-001902-10 Sponsor Protocol Number: 2006/168 Start Date*: 2006-05-31
    Sponsor Name:Kirurgisk Forskningsafsnit, Herning Sygehus
    Full Title: Effects of caffeine on people suffering from intermittens claudication. Three double blinded, placebo-controlled cross-over studies and a follow-up study.
    Medical condition: Intermittens claudication, peripheral arterial disease (PAD) Atherosclerotic disease of the lower extremities
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003626-91 Sponsor Protocol Number: CAFSP01 Start Date*: 2019-04-09
    Sponsor Name:AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
    Full Title: CAFFEINE TREATMENT IN DELIVERY ROOM FOR VERY PRETERM INFANTS : A FEASIBILITY STUDY
    Medical condition: 25+0-29+6 gestational age preterm infants at risk of respiratory distress syndrome with no need of mechanical ventilation in delivery room.
    Disease: Version SOC Term Classification Code Term Level
    21.0 100000004868 10021734 Infant premature LLT
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2022-003202-77 Sponsor Protocol Number: NEOKOFF22 Start Date*: 2023-04-04
    Sponsor Name:
    Full Title: The effect of additional pre-extubational loading dose of caffeine-citrate
    Medical condition: Extubation failure and bronchopulmonary dysplasia
    Disease: Version SOC Term Classification Code Term Level
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10002973 Apnea neonatal LLT
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10071132 Primary apnea of premature newborns LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10077322 Infantile apnea LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10077325 Infantile obstructive apnea LLT
    20.0 10038738 - Respiratory, thoracic and mediastinal disorders 10077328 Infantile central apnea LLT
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10028975 Neonatal respiratory failure PT
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10006475 Bronchopulmonary dysplasia PT
    20.0 100000004868 10076729 Very preterm infant LLT
    23.1 100000004868 10084217 Extremely preterm (less than 28 weeks) LLT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: HU (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2004-003619-22 Sponsor Protocol Number: A2370327 Start Date*: 2004-11-26
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A placebo-controlled study to investigate the efficacy of a combination analgesic treatment compared to its individual components in primary dysmenorrhoea.
    Medical condition: primary dysmenorrhoea
    Disease: Version SOC Term Classification Code Term Level
    7.1 10013935
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-005985-30 Sponsor Protocol Number: rosucaf2 Start Date*: 2009-01-22
    Sponsor Name:Department of Pharmacology-Toxicology
    Full Title: Is augmentation of PORH by rosuvastatin adenosine-receptor mediated?
    Medical condition: mechanism of influence of statins on human adaptive mechanisms in hypoxic circumstances
    Disease: Version SOC Term Classification Code Term Level
    9.1 10021143 Hypoxia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002090-76 Sponsor Protocol Number: CAF-MT Start Date*: 2007-06-14
    Sponsor Name:SERVICIO DE PSIQUIATRIA. HOSPITAL UNIVERSITARI VALL DE HEBRON
    Full Title: Estudio de la eficacia de la cafeína en el tratamiento de mantenimiento de pacientes con dependencia de cocaína
    Medical condition: COCAINE DEPENDENCE
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-002288-16 Sponsor Protocol Number: MOCAFFE Start Date*: 2018-01-24
    Sponsor Name:Center for Man in Aviation
    Full Title: Effects of Modafinil and Caffeine during the circadian trough on vigilance in healthy RNLAF aircrew: a randomized controlled trial
    Medical condition: fatigue in healthy aircew
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2013-004412-22 Sponsor Protocol Number: U-2013-007 Start Date*: 2014-12-12
    Sponsor Name:UCR Uppsala Clinical Research Center
    Full Title: TRIAL OF CAFFEINE TO ALLEVIATE DYSPNEA RELATED TO TICAGRELOR (TROCADERO) A double-blinded, placebo-controlled, randomized, multicenter, development phase II study
    Medical condition: Dyspnea
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004855 10013963 Dyspnea LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-000493-23 Sponsor Protocol Number: A2260335 Start Date*: 2007-04-05
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: A Comparison of Two Analgesic Products for the Treatment of Headache
    Medical condition: Treatment of tension headache
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2012-003882-17 Sponsor Protocol Number: MKM Start Date*: 2013-05-06
    Sponsor Name:Charité Universitaetsmedizin Berlin
    Full Title: Effects of modafinil, caffeine and methylphenidate on functional brain activity and cognitive performance in healthy subjects: a randomized, placebo-controlled, double-blind fMRI study.
    Medical condition: healthy volunteers
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-005343-27 Sponsor Protocol Number: Metformin-FMD001 Start Date*: 2012-01-27
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: Can metformin prevent endothelial ischemia and reperfusion injury? The Metformin-FMD trial.
    Medical condition: ischemia and reperfusion injury endothelial dysfunction
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10063837 Reperfusion injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-004466-14 Sponsor Protocol Number: RH01361 Start Date*: 2011-10-27
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: Effects of two doses of a common cold treatment on cognitive function
    Medical condition: Common cold
    Disease: Version SOC Term Classification Code Term Level
    14.0 10021881 - Infections and infestations 10000938 Acute nasopharyngitis (common cold) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2022-003274-22 Sponsor Protocol Number: 22093 Start Date*: 2022-10-25
    Sponsor Name:Bayer HealthCare LLC
    Full Title: A Randomized, Double-Blind, Single-Dose, Parallel, Placebo-Controlled Pivotal Trial to Confirm the Efficacy of a Fixed Dose Combination Tablet of Naproxen Sodium and Caffeine to Effectively Allevia...
    Medical condition: Postoperative dental pain
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10054711 Postoperative pain LLT
    20.0 100000004856 10059723 Tooth pain LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
    EudraCT Number: 2020-003498-23 Sponsor Protocol Number: SPLENTIR-01/RESCUE Start Date*: 2020-12-18
    Sponsor Name:Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
    Full Title: A multicentre, double-blind, randomized clinical trial for the effectiveness of an analgesic which contains the combination of acetylsalicylic acid-paracetamol and caffeine (400 + 200 + 50 mg / ...
    Medical condition: The aim of the study was to compare the efficacy of an analgesic containing a combination of acetylsalicylic acid, paracetamol and caffeine (SPLENTIR (400 + 200 + 50 mg / tab)) with placebo for the...
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10027605 Migraine NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GR (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-022857-41 Sponsor Protocol Number: C6930943 Start Date*: 2010-12-14
    Sponsor Name:GlaxoSmithKline Consumer Healthcare
    Full Title: Effects of a common cold treatment on cognitive function
    Medical condition: Common cold
    Disease: Version SOC Term Classification Code Term Level
    12.1 10000938 Acute nasopharyngitis (common cold) LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2014-000537-24 Sponsor Protocol Number: IIS-HEPA-TEST Start Date*: 2014-07-16
    Sponsor Name:INSTITUTO DE INVESTIGACION SANITARIA LA FE
    Full Title: Pilot clinical trial phase I / IIa to determine condition, low dose and effectiveness of liver function tests (Hepatotest)
    Medical condition: Hepatic Function.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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