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Clinical trials for Cerebrospinal fluid

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    303 result(s) found for: Cerebrospinal fluid. Displaying page 1 of 16.
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    EudraCT Number: 2019-001863-60 Sponsor Protocol Number: 04/2019 Start Date*: 2019-08-30
    Sponsor Name:Abteilung für Hals-, Nasen- und Ohrenkrankheiten MUW, AKH Wien
    Full Title: Cerebrospinal fluid levels of triamcinolone acetonide
    Medical condition: In this study triamcinolone acetonide levels after intratympanic application in the cerebrospinal fluid will be studied. Patients undergoing surgery with dura access will be asked to participate. P...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2017-002377-19 Sponsor Protocol Number: 1456/2017 Start Date*: 2017-09-15
    Sponsor Name:Abteilung für Hals-, Nasen- und Ohrenkrankheiten MUW, AKH Wien
    Full Title: Triamcinolone levels in cochlear perilymph
    Medical condition: In this study triamcinolone acetonide levels after intratympanic application in the perilymph, and serum of patients receiving a cochlear implant will be studied. In patients undergoing a translaby...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-005535-40 Sponsor Protocol Number: 3599-001 Start Date*: 2016-07-21
    Sponsor Name:Baxter Healthcare Corporation
    Full Title: A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated (FS VH S/D 500 s-apr) Compared to DuraSeal Dural Sealant as an Adjunct ...
    Medical condition: Intra-operative CSF leak
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004852 10024091 Leakage of cerebrospinal fluid LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) CZ (Completed) ES (Completed) PL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-019488-12 Sponsor Protocol Number: Protocol No 1 Start Date*: 2010-12-08
    Sponsor Name:Joint Research Office, Barts and The London NHS Trust
    Full Title: A Single Centre Prospective Randomised Study to Investigate the Metabolism of Intravenous Paracetamol in Humans
    Medical condition: The study is looking at the cerebrospinal fluid pharmacokinetics of intravenous paracetamol.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-005542-42 Sponsor Protocol Number: 2020/11 Start Date*: 2021-03-11
    Sponsor Name:Region Västerbotten
    Full Title: Intrathecal contrast-enhanced MRI for investigation of cerebrospinal fluid transportation
    Medical condition: Cerebrospinal fluid circulation disorder seen in clinically suspected idiopathic normal pressure hydrocephalus
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: SE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2016-004097-17 Sponsor Protocol Number: MEMANTINE001 Start Date*: 2017-04-07
    Sponsor Name:Fakultni nemocnice Hradec Kralove
    Full Title: Evaluation of changes in concentrations of memantine in the cerebrospinal fluid of patients with Alzheimer´s disease.
    Medical condition: Alzheimer's disease
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004852 10001897 Alzheimer's disease (incl subtypes) HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2013-001447-31 Sponsor Protocol Number: 954 Start Date*: 2014-01-14
    Sponsor Name:Liverpool Heart and Chest Hospital NHS Foundation Trust
    Full Title: A randomised controlled trial to study the effect of acetazolamide on the incidence of blood-stained CSF, effect on cerebrospinal fluid (CSF) pressure, CSF drainage and neurological dysfunction in ...
    Medical condition: Elevated cerebrospinal fluid pressure in patients undergoing thoracic-abdominal aortic repair
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2015-004427-31 Sponsor Protocol Number: TAFCNS2015 Start Date*: 2016-03-07
    Sponsor Name:Gothenburg University
    Full Title: Tenofovir Alafenamide Fumarate (TAF) effect on residual intrathecal immune activation
    Medical condition: HIV-infection in the central nervous system
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004414-10 Sponsor Protocol Number: TERIFL08519 Start Date*: 2018-02-23
    Sponsor Name:MS Centrum, Department of Neurology, Sshlgrenska University Hospital
    Full Title: Determination of the concentration of Teriflunomide in serum and cerebrospinal fluid from patients with multiple sclerosis who are treated with Teriflunomide 14 mg daily.
    Medical condition: Multiple Sclerosis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-000302-39 Sponsor Protocol Number: IN-ES-380-4475 Start Date*: 2018-06-18
    Sponsor Name:Fundació Lluita contra la SIDA
    Full Title: Bictegravir concentrations and antiviral activity in cerebrospinal fluid in HIV-1 Infected individuals
    Medical condition: HIV-1 infected individuals
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2007-001795-37 Sponsor Protocol Number: AMB TS Start Date*: 2007-07-19
    Sponsor Name:Medical University Innsbruck, Dpt. Internal Medicine, Div. Internal Medicine
    Full Title: WIRKORTKONZENTRATIONEN VON AMPHOTERICIN B FORMULIERUNGEN IN ASZITES, LIQUOR, PLEURAERGUSS, GALLE UND LIQUOR BEI KRITISCH KRANKEN (Target-site concentrations of Amphotericin B preparations in ascit...
    Medical condition: Plasma and target-site (ascites, pleural effusion, bile and cerebrospinal fluid) concentrations of amphotericin B preparations will be measured in critically ill patients, requiring treatment with ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2015-001673-40 Sponsor Protocol Number: 2015/96 Start Date*: 2015-06-29
    Sponsor Name:Oslo University Hospital
    Full Title: INTRATHECAL CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING
    Medical condition: Cerebrospinal fluid circulation disorder seen in the following clinical disease states: Communicating hydrocephalus, idiopathic intracranial hypertension, idiopathic intracranial hypotension, intra...
    Disease:
    Population Age: Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2017-003586-94 Sponsor Protocol Number: DONEPEZIL001 Start Date*: 2018-01-08
    Sponsor Name:Fakultní nemocnice Hradec Králové
    Full Title: Monitoring of changes in donepezil concentrations, biomarkers of oxidative stress and activity of acetylchonesterase in the cerebrospinal fluid and plasma of patients with Alzheimer disease.
    Medical condition: Alzheimer's disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10001897 Alzheimer's disease (incl subtypes) HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-003854-80 Sponsor Protocol Number: 02B2005 Start Date*: 2006-01-31
    Sponsor Name:Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University
    Full Title: Modulation of the Surgical Inflammatory Response by Etoricoxib: Peripheral versus Central
    Medical condition: Patients with osteoarthritis undergoing elective primary single hip arthroplasty
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2013-005065-38 Sponsor Protocol Number: ECHI-TS-2 Start Date*: 2014-02-17
    Sponsor Name:Medizinische Universität Innsbruck, Universitätsklinik für Innere Medizin I
    Full Title: Concentrations of echinocandins in ascites, pleural effusion, bile, wound secretion and cerebrospinal fluid – a pilot study
    Medical condition: Invasive fungal infection treated with an echinocandin and indication for paracentesis, thoracentesis, bile deviation or sampling, lumbar puncture or VAC therapy
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-000219-14 Sponsor Protocol Number: 1957 Start Date*: 2008-03-19
    Sponsor Name:North Bristol NHS Trust
    Full Title: Efficacy of 8.4% sodium bicarbonate in adult patients with closed head injuries and intracranial hypertension.
    Medical condition: Raised intracranial pressure after severe head injury.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10022764 Intracranial hypertension LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2014-000496-64 Sponsor Protocol Number: SCALA Start Date*: 2014-04-23
    Sponsor Name:Dr. Daniel Podzamczer Palter. Hospital Univesitari de Bellvitge. Unidad de VIH.
    Full Title: Viral suppression in Cerebrospinal Fluid in HIV-1 infected patients receiving Ritonavir-boosted Atazanavir plus lamivudine dual theraphy. SCALA study
    Medical condition: HIV-1 infection
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-022085-26 Sponsor Protocol Number: rhLAMAN-03 Start Date*: 2010-10-05
    Sponsor Name:Zymenex A/S
    Full Title: A single center, randomized, open-label, multiple-dose study of the efficacy and long-term safety of rhLAMAN (recombinant human alpha-mannosidase or Lamazym) for the treatment of patients with alph...
    Medical condition: Treatment of alpha-Mannosidosis
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2010-018920-21 Sponsor Protocol Number: ZICBOL2010 Start Date*: 2011-03-23
    Sponsor Name:Landstinget i Östergötland
    Full Title: Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide(Prialt®) - The Swedish Ziconotide Bolus Study
    Medical condition: Chronic pain
    Disease: Version SOC Term Classification Code Term Level
    12.1 10049475 Chronic pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-003032-23 Sponsor Protocol Number: AADC-010 Start Date*: 2019-10-09
    Sponsor Name:National Taiwan University Hospital
    Full Title: A Phase I/II Clinical Trial for Treatment of Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC
    Medical condition: Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency
    Disease:
    Population Age: Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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