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Clinical trials for Chemoprevention

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44341   clinical trials with a EudraCT protocol, of which   7370   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    17 result(s) found for: Chemoprevention. Displaying page 1 of 1.
    EudraCT Number: 2008-003696-43 Sponsor Protocol Number: KUN 2008-4198 Start Date*: 2008-11-25
    Sponsor Name:KWF Kankerbestrijding
    Full Title: Prevention of progression of duodenal adenomas to cancer in patients with familial adenomatous polyposis
    Medical condition: Familial Adenomatous Polyposis Duodenal adenomas and carcinomas
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003021-19 Sponsor Protocol Number: BCPP2005-01 Start Date*: 2006-08-22
    Sponsor Name:University Of Birmingham
    Full Title: The use of selenium and vitamin E supplementation to prevent recurrence and progression of non-muscle-invasive bladder cancer
    Medical condition: Non-muscle-invasive transitional cell carcinoma of the bladder
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2004-003836-77 Sponsor Protocol Number: OCTO-003 Start Date*: 2008-12-09
    Sponsor Name:University of Oxford
    Full Title: AspECT - A phase III, randomised study of aspirin and esomeprazole chemoprevention in Barrett's metaplasia & oesophagitis.
    Medical condition: Barrett's Metaplasia
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-001084-27 Sponsor Protocol Number: APAC Start Date*: 2006-06-16
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALI GALLIERA
    Full Title: Phase I/II study of prevention of Colorectal Cancer CRC with Allopurinol in High-Risk Subjects
    Medical condition: CHEMOPREVENTION OF COLORECTAL CANCER
    Disease: Version SOC Term Classification Code Term Level
    9.1 10048832 Colon adenoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001087-11 Sponsor Protocol Number: 15112SMcI-SS Start Date*: 2016-06-23
    Sponsor Name:Belfast Health and Social Care Trust
    Full Title: Chemoprevention in BRCA1 mutation carriers - a proof of concept study
    Medical condition: BRCA1 mutation carrier Breast Cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10057654 Breast cancer female PT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10057654 Breast cancer female PT
    20.0 10041244 - Social circumstances 10064117 Familial risk factor PT
    20.0 10041244 - Social circumstances 10064117 Familial risk factor PT
    Population Age: Adults Gender: Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-009921-28 Sponsor Protocol Number: PLOTINA Start Date*: 2010-05-15
    Sponsor Name:ISTITUTI FISIOTERAPICI OSPITALIERI
    Full Title: The Effect of Metformin, an insulin-sensitizing drug, on Breast Cancer Primary Prevention: The Plotina Breast Cancer Prevention Randomized, Placebo Controlled Trial
    Medical condition: Breast cancer chemoprevention
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-002101-65 Sponsor Protocol Number: PI17/01109 Start Date*: 2018-11-19
    Sponsor Name:Ángel Lanas Arbeloa-Instituto de Investigación Sanitaria Aragón
    Full Title: Assessment of direct biomarkers of aspirin action to develop a precision chemoprevention therapy of colorectal cancer
    Medical condition: Colorectal cancer with a recent confirmed diagnosis (less than 48h)
    Disease: Version SOC Term Classification Code Term Level
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10061451 Colorectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-000759-32 Sponsor Protocol Number: CAT 06 Start Date*: 2007-04-18
    Sponsor Name:SOFAR SPA
    Full Title: Evaluation of the efficacy of green tea catechins (Categ Plus) in the chemoprevention of prostatic carcinoma in patients with high grade PIN. A randomised multicentric, double blind clinical study.
    Medical condition: Prostatic intraepithelial neoplasia
    Disease: Version SOC Term Classification Code Term Level
    9.1 10036964 Prostatic intraepithelial neoplasia LLT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-010921-38 Sponsor Protocol Number: MDL_2009_27155 Start Date*: 2009-09-08
    Sponsor Name:UMC Utrecht
    Full Title: Chemopreventive effects of 5-ASA and UDCA in Ulcerative Colitis: A Double-blind, Randomized Placebo-controlled Pilot Study
    Medical condition: Ulcerative Colitis and the risk of developing colorectal cancer.
    Disease: Version SOC Term Classification Code Term Level
    13.1 10017947 - Gastrointestinal disorders 10021972 Inflammatory bowel disease PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-002024-32 Sponsor Protocol Number: Mesapol Start Date*: 2012-09-21
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für Innere Medizin 3, Abteilung für Gastroenterologie und Hepatologie
    Full Title: Mesapol: The effect of mesalazine on molecular pathways of cell adhesion in patients with colon polyps
    Medical condition: Colon polyps
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004856 10066021 Acquired colon polyposis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2014-001784-13 Sponsor Protocol Number: ISRCTN91422391 Start Date*: 2014-12-29
    Sponsor Name:Queen Mary University of London
    Full Title: PROVENT: A randomised, double blind, placebo controlled feasibility study to examine the clinical effectiveness of aspirin and/or Vitamin D3 to prevent disease progression in men on active surveill...
    Medical condition: Prostate cancer disease progression
    Disease: Version SOC Term Classification Code Term Level
    18.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10060862 Prostate cancer PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2010-020943-10 Sponsor Protocol Number: GA10/9312 Start Date*: 2011-03-16
    Sponsor Name:University of Leeds
    Full Title: A randomised controlled trial of eicosapentaenoic acid (EPA) and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme...
    Medical condition: colorectal adenoma (polyp)
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004864 10048841 Bowel cancer LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-002836-18 Sponsor Protocol Number: EPA/POL/03 Start Date*: 2006-10-09
    Sponsor Name:S.L.A. Pharma (UK) Ltd
    Full Title: A Two-Arm Chemoprevention Trial in Familial Adenomatous Polyposis Coli Patients Using the Purified Free Fatty Acid, Eicosapentaenoic Acid.
    Medical condition: Familial adenomatous polyposis (FAP)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10059327 Familial adenomatous polyposis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-005999-18 Sponsor Protocol Number: PI20/01514 Start Date*: 2022-06-24
    Sponsor Name:Instituto de Investigación Sanitaria Aragón
    Full Title: Effect of obesity on COX1 and 2 acetylation by aspirin as a biomarker of its efficacy in colon cancer chemoprevention and therapy.
    Medical condition: Colorectal cancer
    Disease: Version SOC Term Classification Code Term Level
    21.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10061451 Colorectal cancer PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-007740-10 Sponsor Protocol Number: TAM-01 Start Date*: 2008-01-30
    Sponsor Name:AZIENDA OSPEDALIERA OSPEDALI GALLIERA
    Full Title: Randomized placebo-controlled phase III trial of low-dose tamoxifen women whit IntraEphitelial Neoplasia(IEN)
    Medical condition: chemoprevention of breast cancer
    Disease: Version SOC Term Classification Code Term Level
    9.1 10006187 Breast cancer LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2018-000743-66 Sponsor Protocol Number: NAMCHEM Start Date*: 2018-07-10
    Sponsor Name:FONDAZIONE LUIGI MARIA MONTI IDI-IRCCS
    Full Title: Multicenter, interventional, single-arm, phase IV study on specific metabolic and genomic profiles as predictors of nicotinamide efficacy in cutaneous squamous cell carcinoma prevention
    Medical condition: Cutaneous squamous-cell carcinoma (cSCC) is the most common age-associated malignancy that usually arises from the lesion actinic keratosis (AK) or grows de novo in photoexposed areas.
    Disease: Version SOC Term Classification Code Term Level
    20.0 10040785 - Skin and subcutaneous tissue disorders 10000614 Actinic keratosis PT
    21.1 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10059813 Spinocellular carcinoma LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-005431-15 Sponsor Protocol Number: ML 5220 Start Date*: 2008-12-24
    Sponsor Name:ACHG-K.U.Leuven
    Full Title: PHASE III RANDOMIZED CHEMOPREVENTION STUDY OF SELENIUM ON THE RECURRENCE OF NON-INVASIVE BLADDER CANCER
    Medical condition: Bladder cancer
    Disease: Version SOC Term Classification Code Term Level
    9.1 10005014 Bladder carcinoma LLT
    9.1 10005003 Bladder cancer LLT
    9.1 10005004 Bladder cancer NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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