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Clinical trials for Clostridium botulinum

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    96 result(s) found for: Clostridium botulinum. Displaying page 1 of 5.
    1  2  3  4  5  Next»
    EudraCT Number: 2013-004646-42 Sponsor Protocol Number: 05PF1311 Start Date*: 2014-03-17
    Sponsor Name:Q-MED AB
    Full Title: A randomized, evaluator-blinded, comparative study to evaluate the efficacy and safety of different injection volumes of botulinum toxin type A, Azzalure®, in the glabellar lines.
    Medical condition: Glabella frown lines
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004858 10052609 Glabellar frown lines LLT
    Population Age: Adults Gender: Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2005-005235-96 Sponsor Protocol Number: BTX0506 Start Date*: 2005-12-09
    Sponsor Name:Cranley Clinic
    Full Title: A Double-Blind Comparison of the Safety and Efficacy of Dysport® and BOTOX® (Botulinum Toxin Type A) in the Treatment of Female Subjects with Severe Glabellar Rhytids
    Medical condition: Severe glabellar rhytids
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-010338-23 Sponsor Protocol Number: RD.03.SPR.29081 Start Date*: 2009-06-09
    Sponsor Name:GALDERMA Research & Development
    Full Title: Intra-individual randomized comparison of the efficacy of two botulinum toxins type A on moderate to severe forehead wrinkles after one injection
    Medical condition: Moderate to severe forehead wrinkles
    Disease: Version SOC Term Classification Code Term Level
    9.1 10040954 Skin wrinkling LLT
    Population Age: Adults Gender: Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2008-002713-40 Sponsor Protocol Number: MRZ60201-GL-3002 Start Date*: 2008-11-06
    Sponsor Name:Merz Pharmaceuticals GmbH
    Full Title: A prospective, multicenter, randomized, rater- and subject-blind, parallel group trial to investigate the non-inferiority of NT 201, free of complexing proteins, in comparison with Clostridium botu...
    Medical condition: Treatment of glabellar frown lines
    Disease: Version SOC Term Classification Code Term Level
    10.1 10052609 LLT
    Population Age: Adults Gender: Female
    Trial protocol: DE (Completed) AT (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-015125-36 Sponsor Protocol Number: NCT00934687 Start Date*: Information not available in EudraCT
    Sponsor Name:Medical School Hannover. Department of Psychiatry, Social Psychiatry and Psychotherapy
    Full Title: Clostridium botulinum Typ A Neurotoxinkomplex zur adjuvanten Behandlung von depressiven Störungen – Eine randomisierte, kontrollierte Pilotstudie
    Medical condition: Botulinum Toxin for the Treatment of Depression
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-003132-30 Sponsor Protocol Number: BTXHH11 Start Date*: 2011-09-09
    Sponsor Name:Svettmottagningen Hidroskliniken, Stockholm
    Full Title: Botulinum toxin treatment in craniofacial, inguinal, palmar, plantar and truncal hyperhidrosis, a randomized, double blind, placebo controlled study.
    Medical condition: Hyperhidrosis-craniofacial, inguinal, palmar, plantar and truncal.
    Disease: Version SOC Term Classification Code Term Level
    17.1 10040785 - Skin and subcutaneous tissue disorders 10020642 Hyperhidrosis PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-006169-15 Sponsor Protocol Number: ALLCD001 Start Date*: 2006-05-18
    Sponsor Name:Allergan Limited
    Full Title: A Double-Blind, Randomised, Cross-over, Safety and Efficacy Pilot Study Comparing Two Botulinum Toxin Type-A Products in the Treatment of Moderate to Severe Cervical Dystonia.
    Medical condition: Cervical dystonia is the most common form of focal dystonia prevalent at a rate of 89 per million individuals. Sustained involuntary contractions of the neck muscles, lead to painful and disabling ...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-006170-10 Sponsor Protocol Number: ALLBL001 Start Date*: 2006-06-22
    Sponsor Name:Allergan Limited
    Full Title: A Double-Blind, Randomised, Parallel group, Safety and Efficacy Pilot Study Comparing Two Botulinum Toxin Type-A Products in the Treatment of Blepharospasm
    Medical condition: Blepharospasm is a focal dystonia characterised by excessive involuntary contraction of the orbicularis oculi muscles. In severe cases, tonic eyelid closure can lead to functional blindness and can...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2006-000129-76 Sponsor Protocol Number: BTXSENS Start Date*: 2007-04-27
    Sponsor Name:Guy's & St Thomas' NHS Foundation Trust
    Full Title: Botulinum toxin-A in Sensory Urgency
    Medical condition: Sensory Urinary Urgency. This is a condition where patients have urinary urgency (sudden desire to urinate which cannot be deferred) /- urge incontinence (urine leakage) and usually is accompanied ...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10059617 Overactive bladder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-021257-39 Sponsor Protocol Number: PB-PG-0808-16319 Start Date*: 2011-07-26
    Sponsor Name:SWBH NHS Trust [...]
    1. SWBH NHS Trust
    2. Keele University
    Full Title: Is it clinically effective to treat arm flexor spasticity, with Botulinum toxin – type A (BoNTA) and physiotherapy, as soon as signs of abnormal muscle activity are observed? (A phase II study)
    Medical condition: Stroke.Spasticity.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2020-005653-24 Sponsor Protocol Number: IRB00003099 Start Date*: 2021-06-28
    Sponsor Name:Clínica Integral del pie-Ana Sans
    Full Title: Effectiveness of botulinum toxin infiltration in spasticity of the 1st toe in patients with neurological pathology
    Medical condition: The application of Botox is described in the technical sheet for spasticity and has already been applied to the foot. This is how we speak of a phase IV clinical trial, with a low level of interven...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019907-43 Sponsor Protocol Number: Y-52-52120-134 Start Date*: 2011-03-04
    Sponsor Name:Ipsen Innovation
    Full Title: A phase III, randomised, double blind and open label phase, active and placebo controlled study comparing the short term efficacy of two formulations of clostridium botulinum type A toxin (Dysport ...
    Medical condition: Cervical Dystonia
    Disease: Version SOC Term Classification Code Term Level
    14.1 10028395 - Musculoskeletal and connective tissue disorders 10064124 Cervical dystonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: PT (Completed) CZ (Completed) DE (Completed) BE (Completed) AT (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2005-004637-17 Sponsor Protocol Number: 191622-080-00 Start Date*: 2006-04-04
    Sponsor Name:ALLERGAN LTD
    Full Title: A Multicenter Study Evaluating the Efficacy and Safety of BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex as Headache Prophylaxis in Migraine Patients with 15 or More Headache Days per ...
    Medical condition: Headache prophylaxis in migraine patients with 15 or more headache days per month
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-009868-31 Sponsor Protocol Number: 80-82310-98-09088 Start Date*: 2009-06-18
    Sponsor Name:ZonMW
    Full Title: Quality of life, gross motor function, and actual everyday physical activity level in children with spastic Cerebral Palsy: (cost)effectiveness of combined treatment with multilevel botulinum-toxin...
    Medical condition: Spastic Cerebral Palsy, GMFCS levels I-III
    Disease:
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004391-29 Sponsor Protocol Number: InBoTox Start Date*: 2016-04-06
    Sponsor Name:Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS)
    Full Title: Effectiveness of intragastric injection of botulinum toxin by endoscopy in obese patients in surgical waiting list. Study InBoTox
    Medical condition: Morbid obesity
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-001378-29 Sponsor Protocol Number: RAE02 Start Date*: 2005-05-23
    Sponsor Name:Bradford Teaching Hospitals NHS Foundation Trust
    Full Title: A double blinded randomised controlled trial of injection of botulinum toxin versus normal saline into the puborectalis muscle in patients with pelvic floor dyssynergia.
    Medical condition: Obstructed defeacation
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-001095-13 Sponsor Protocol Number: Start Date*: 2005-06-13
    Sponsor Name:Medical University Innsbruck
    Full Title: Intragastrale Injektion von Botulinum Toxin A zur Behandlung der Adipositas
    Medical condition: Die morbide Adipositas nimmt in westlichen Ländern stetig zu. In Österreich und Deutschland sind ca. 30% der Erwachsenen übergewichtig und 1% (900.000 Erwachsene) morbid adipös. In den USA stellt d...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2013-004293-10 Sponsor Protocol Number: REH-TOX-2013-01 Start Date*: 2014-06-03
    Sponsor Name:Hospital Universitari de Tarragona Joan XXIII
    Full Title: Efficacy of treatment by iontophoresis of botulinum toxin type A free from complexing proteins for stump hyperhidrosis
    Medical condition: Stump hyperhidrosis in lower limb amputees
    Disease: Version SOC Term Classification Code Term Level
    16.1 10040785 - Skin and subcutaneous tissue disorders 10020642 Hyperhidrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-005742-42 Sponsor Protocol Number: SCALA Start Date*: 2023-04-13
    Sponsor Name:Groupement de Coopération Sanitaire Ramsay Générale de Santé pour l’Enseignement et la Recherche
    Full Title: Effect of botulinum toxin on hamstring contracture and the occurrence of cyclops syndrome after anterior cruciate ligament reconstruction
    Medical condition: Cyclops syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10058029 Arthrofibrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-001443-29 Sponsor Protocol Number: A-92-52120-089 Start Date*: 2004-11-19
    Sponsor Name:Ipsen Pharma, S.A.
    Full Title: A multicentre, randomized, double-blind, parallel and controlled with placebo pilot study to evaluate the efficacy and safety of a single dose of botulinum toxin Type A (Dysport®) associated with r...
    Medical condition: Pain caused by primary myofascial syndrome of cervical and dorsal localization
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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