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Clinical trials for Esophageal sphincter

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44363   clinical trials with a EudraCT protocol, of which   7387   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    10 result(s) found for: Esophageal sphincter. Displaying page 1 of 1.
    EudraCT Number: 2016-000563-16 Sponsor Protocol Number: Citalopram2016 Start Date*: 2016-06-09
    Sponsor Name:K.U. Leuven
    Full Title: Effect of citalopram on fasting and postprandial lower esophageal sphincter function in healthy subjects: a double-blind, placebo-controlled, randomized, cross-over study
    Medical condition: Increased lower esophageal sphincter pressure
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2008-006081-29 Sponsor Protocol Number: Rimonaslok Start Date*: 2008-10-21
    Sponsor Name:UZLeuven
    Full Title: INFLUENCE OF RIMONABANT ON LOWER ESOPHAGEAL FUNCTION IN HEALTHY VOLUNTEERS
    Medical condition: none; this is a physiological study to investigate the influence of CB1 receptor antagonism by rimonabant (normally used for the treatment of obesity) on esophageal function, i.e. esophageal contr...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2006-004501-25 Sponsor Protocol Number: D9120C00020 Start Date*: 2006-12-18
    Sponsor Name:AstraZeneca AB
    Full Title: A double-blind, placebo controlled, randomized, two centre phase IIa pharmacodynamic cross-over study to assess the effect of AZD3355, 65 mg bid, on transient lower esophageal sphincter relaxations...
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed)
    Trial results: View results
    EudraCT Number: 2016-000532-17 Sponsor Protocol Number: Methylnaltrexone2016 Start Date*: 2016-06-09
    Sponsor Name:K.U. Leuven
    Full Title: Effect of methylnaltrexone on intragastric pressure, the occurrence of transient lower esophageal sphincter relaxations and reflux events in healthy subjects: a double-blind, placebo-controlled, ra...
    Medical condition: Impaired gastric accommodation
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-018608-98 Sponsor Protocol Number: D3830C00001 Start Date*: 2010-06-09
    Sponsor Name:AstraZeneca AB
    Full Title: A double-blind, randomized, placebo-controlled, two-centre, phase IIa pharmacodynamic cross-over study to assess the effect of AZD2516 on the total number of reflux episodes in healthy male volunteers
    Medical condition: Gastroesophageal Reflux Disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    12.1 10017924 Gastroesophageal reflux LLT
    Population Age: Adults Gender: Male
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2009-013080-19 Sponsor Protocol Number: 27538 Start Date*: 2010-03-31
    Sponsor Name:AMC
    Full Title: Prokinetics to alter the position of the gastric acid pocket in Gastro Esophageal Reflux Disease
    Medical condition: gastro-esophageal reflux disease (GERD)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10000479 Acid reflux (oesophageal) LLT
    9.1 10017884 Gastrooesophageal reflux LLT
    9.1 10017885 Gastrooesophageal reflux disease LLT
    9.1 10038262 Reflux esophagitis LLT
    9.1 10020024 Hiatal hernia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-001202-14 Sponsor Protocol Number: CiPA001 Start Date*: 2019-06-05
    Sponsor Name:Amsterdam UMC
    Full Title: CiPA Trial: Effect of Citalopram on chest pain in patients with achalasia
    Medical condition: Achalasia is a motility disorder of the esophagus. Disappearance of myenteric neurons in the esophageal wall leads to failure of relaxation of the lower esophageal sphincter (LES) and impaired peri...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-002182-35 Sponsor Protocol Number: buspirone2019 Start Date*: 2019-09-10
    Sponsor Name:KU Leuven - TARGID
    Full Title: The effect of oral buspirone hydrochloride on esophageal motility, bolus transit and symptoms of dysphagia, in patients with poor esophageal motility: A randomized, double-blind, placebo controlle...
    Medical condition: Patients with complaints of dysphagia and poor esophageal motility
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2019-002185-13 Sponsor Protocol Number: clebopride2019 Start Date*: 2019-10-03
    Sponsor Name:KU Leuven - TARGID
    Full Title: A Randomized, Double Blind, Placebo Controlled, Crossover Trial of Clebopride vs Placebo in the Treatment of Clinically Suspected Rumination.
    Medical condition: rumination syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2015-005216-15 Sponsor Protocol Number: ABO-NB-15 Start Date*: 2016-07-06
    Sponsor Name:ABOCA S.P.A. SOCIETà AGRICOLA
    Full Title: Relief of heartburn and epigastric pain comparing Neobianacid® with omeprazole: a randomized, double blind, double dummy, reference product controlled, parallel group, non-inferiority clinical study
    Medical condition: GERD (Gastroesophageal Reflux Disease) and/or EPS (Epigastric Pain Syndrome)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004856 10015015 Epigastric burning LLT
    20.1 100000004856 10066998 Gastroesophageal burning LLT
    20.1 100000004856 10066990 Gastrooesophageal burning LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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