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Clinical trials for HMG-CoA

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
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    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    36 result(s) found for: HMG-CoA. Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2006-004686-34 Sponsor Protocol Number: Evaluation Statin Therapy Start Date*: 2007-02-27
    Sponsor Name:Karolinska University Hospital
    Full Title: Evaluation of Statin Therapy- Safety, Effect and Toxicity Mechanisms.
    Medical condition: Frequency of side effects in patients treated with HMG CoA reductase inhibitors.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10058108 Dyslipidaemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-005143-28 Sponsor Protocol Number: MED.RES.HOS.2006.03.LP Start Date*: 2006-12-06
    Sponsor Name:Medicinsk Forskning
    Full Title: Effects of HMG-CoA-reductase inhibition (atorvastatin) on renal sodium excretion, renal hemodynamics, tubular function and vasoactive hormones in healthy subjects under diet with normal and high so...
    Medical condition: Healthy volunteer trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006234-34 Sponsor Protocol Number: CD07/8396 Start Date*: 2008-08-18
    Sponsor Name:University of Leeds
    Full Title: 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: endothelial and endothelial progenitor cell function in men
    Medical condition: Objectives:To investigate whether statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) improve endothelial dysfunction in healthy volunteers (men). Endothelial dysfunction is an ear...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-000284-28 Sponsor Protocol Number: 48/05 Start Date*: 2006-05-31
    Sponsor Name:Universitätsklinikum des Saarlandes
    Full Title: Einfluss einer Behandlung mit dem HMG-CoA Reduktasehemmer Fluvastatin auf die Erektionsfähigkeit bei Patienten mit kardiovaskulären Risikofaktoren und erektiler Dysfunktion
    Medical condition: erectile dysfunction due to vascular impairment
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-004876-19 Sponsor Protocol Number: 01-05-TL-475-021 Start Date*: 2006-02-13
    Sponsor Name:Takeda Europe R&D Centre Ltd
    Full Title: A Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of TAK-475 100 mg or Placebo When Co-Administered With High Dose Statin Therapy in Subjects With Primary Hypercholesterolemia
    Medical condition: Treatment of patients with primary hypercholesterolemia currently taking atorvastatin (80mg), simvastatin (80mg) or rosuvastatin (40mg)
    Disease: Version SOC Term Classification Code Term Level
    8 10058108 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Completed) SE (Prematurely Ended) NO (Completed) FI (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2011-001529-26 Sponsor Protocol Number: 20090159 Start Date*: 2011-07-15
    Sponsor Name:Amgen Inc
    Full Title: A Randomized, Multicenter Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C, Compared with Ezetimibe, in Hypercholesterolemic Subjects Unable to Tolerate an Effective Dose of a HMG-Co...
    Medical condition: Hypercholesterolaemia
    Disease: Version SOC Term Classification Code Term Level
    13.1 10027433 - Metabolism and nutrition disorders 10020603 Hypercholesterolaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) BE (Completed) SE (Completed) DK (Completed) FI (Completed)
    Trial results: View results
    EudraCT Number: 2009-013622-17 Sponsor Protocol Number: REMEDY Start Date*: 2009-10-20
    Sponsor Name:CARDIOLOGIA UNIVERSITARIA - OSPEDALE CLINICIZZATO SS. ANNUNZIATA - VIA DEI VESTINI - 66013 CHIETI
    Full Title: ROSUVASTATIN FOR REDUCTION OF MYOCARDIAL DAMAGE AND SYSTEMIC INFLAMMATION DURING CORONARY ANGIOPLASTY - The REMEDY Study
    Medical condition: In patients with suspected stable CAD candidates to PCI
    Disease: Version SOC Term Classification Code Term Level
    12.1 10011085 Ischaemic coronary artery disorders HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005508-62 Sponsor Protocol Number: TRINACRIA Start Date*: 2015-10-08
    Sponsor Name:ISTITUTI FISIOTERAPICI OSPITALIERI
    Full Title: A phase II, randomized, non-comparative, pre-surgical study of atorvastatin or observation in Ki-67 positive, TAZ-expressing early breast cancer patients
    Medical condition: Early breast cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10006175 Breast adenocarcinoma stage I LLT
    20.0 100000004864 10006176 Breast adenocarcinoma stage II LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-017060-17 Sponsor Protocol Number: STIMULATE1.0 Start Date*: 2009-12-10
    Sponsor Name:Academic Medical Center
    Full Title: STIMULATE study: Statins influence on Minrin upregulation of von Willebrand factor and factor VIII
    Medical condition: Type 1 von Willebrand disease and mild hemophilia A
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003041-14 Sponsor Protocol Number: 565 Start Date*: 2005-09-20
    Sponsor Name:Department of Clinical Pharmacology, Medical University of Vienna
    Full Title: Anti-inflammatory effect of statins in the human endotoxin model
    Medical condition: Healthy volunteers are tested in an endotoxemia model
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2006-003539-56 Sponsor Protocol Number: 1.01 Start Date*: 2006-11-10
    Sponsor Name:Medical University of Vienna, Department of Internal Medicine IV
    Full Title: Simvastatin in patients with septic shock
    Medical condition: Septic shock
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2005-000691-41 Sponsor Protocol Number: AR001 Start Date*: 2005-04-11
    Sponsor Name:Greater Glasgow Health Board, North Glasgow University Hospitals Division
    Full Title: Randomised controlled trial to evaluate the effect of statins on asthma control of patients with chronic asthma.
    Medical condition: Chronic Asthma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2008-005147-42 Sponsor Protocol Number: 78143605 Start Date*: 2009-02-25
    Sponsor Name:Mª Angeles Aguirre Zamorano
    Full Title: Arteriosclerosis y Lupus Eritematoso Sistémico: ¿Pueden las Estatinas detener este proceso?
    Medical condition: Prevención primaria del desarrollo de arteriosclerosis precoz en pacientes con Lupus Eritematoso Sistémico.
    Disease: Version SOC Term Classification Code Term Level
    9 10003210 Arteriosclerosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-000775-34 Sponsor Protocol Number: 01-04-TL-475-002 Start Date*: 2004-11-17
    Sponsor Name:Takeda Europe R&D Centre Ltd
    Full Title: A double-blind, randomised, parallel group study to evaluate the safety, tolerability and efficacy of TAK-475 alone or co-administered with atorvastatin in patients with primary dyslipidemia
    Medical condition: Treatment of patients with primary dyslipidemia
    Disease: Version SOC Term Classification Code Term Level
    7 10058108 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) LT (Completed) CZ (Completed) EE (Completed) SK (Completed) LV (Completed) GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-001550-41 Sponsor Protocol Number: EFC6910 Start Date*: 2008-08-14
    Sponsor Name:Sanofi-Aventis Recherche & Développement
    Full Title: A multicenter, double-blind, randomized, 12-month, placebo-controlled study to evaluate the lipid-lowering effect, safety and tolerability of AVE5530 25 mg/day and 50mg/day when added to ongoing st...
    Medical condition: Primary Hypercholesterolemia
    Disease: Version SOC Term Classification Code Term Level
    11.0 10060375 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) CZ (Completed) DE (Prematurely Ended) SE (Prematurely Ended) ES (Completed) HU (Completed) BE (Completed) DK (Prematurely Ended) PT (Prematurely Ended) PL (Prematurely Ended) NL (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-006937-28 Sponsor Protocol Number: OPHT-040908 Start Date*: 2009-03-30
    Sponsor Name:Universitätsklinik für Klinische Pharmakologie
    Full Title: Effect of Rosuvastatin on endothelial function in patients with diabetes and glaucoma
    Medical condition: volunteers with Diabetes type I or II and volunteers with Glaucoma are included Glaucoma
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012602 Diabetes mellitus (incl subtypes) HLT
    9.1 10018305 Glaucomas (excl congenital) HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-000647-14 Sponsor Protocol Number: 15782601 Start Date*: 2016-05-23
    Sponsor Name:University Hospital Toulouse
    Full Title: Treatment with HMG-COA reductase inhibitor (simvastatin) of growth and bone abnormalities in children with Noonan syndrome : a phase III randomised, double-blind, placebo-controlled therapeutic trial
    Medical condition: Noonan syndrome
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2005-000812-29 Sponsor Protocol Number: AMB 320 Start Date*: 2005-09-21
    Sponsor Name:Myogen, Inc.
    Full Title: Ambrisentan in PAH - A Phase III, Randomised, Double- Blind, Placebo- Controlled, Multicenter, Efficacy Study of Ambrisentan in Subjects with Pulmonary Arterial Hypertension
    Medical condition: Pulmonary Arterial Hypertension
    Disease: Version SOC Term Classification Code Term Level
    7.0 10037400 low
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) ES (Completed) AT (Completed) BE (Completed) IT (Completed) DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2004-000156-16 Sponsor Protocol Number: A509 1043 Start Date*: 2004-09-14
    Sponsor Name:Pfizer AB
    Full Title: Phase 3 multi center, double blind, randomized, parallel group evaluation of the fixed combination torcetrapib/atorvastatin, administered orally, once daily (QD), compared with atorvastatin alone, ...
    Medical condition: Coronary Heart Disease
    Disease: Version SOC Term Classification Code Term Level
    10011078
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) ES (Completed) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-005177-21 Sponsor Protocol Number: HGS1006-C1056 Start Date*: 2007-05-29
    Sponsor Name:Human Genome Sciences, Inc.
    Full Title: A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled 76 week Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Ant...
    Medical condition: Systemic Lupus Erythematosus (SLE)
    Disease: Version SOC Term Classification Code Term Level
    8.1 10042945 Systemic lupus erythematosus LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) BE (Completed) DE (Completed) AT (Completed) CZ (Completed) ES (Completed) SK (Completed) SE (Completed) NL (Completed) IT (Completed) FR (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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