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Clinical trials for Ischemia

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    524 result(s) found for: Ischemia. Displaying page 1 of 27.
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    EudraCT Number: 2013-000887-27 Sponsor Protocol Number: 1.0 Start Date*: 2013-05-23
    Sponsor Name:Medizinische Universität Wien
    Full Title: Pilot Trial: The effects of intravenous heme arginate on HO-1 expression and oxidative stress in the human heart
    Medical condition: ischemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004849 10055224 Cardiac ischemia LLT
    14.1 100000004849 10023031 Ischemia coronary artery origin LLT
    14.1 100000004849 10023033 Ischemia myocardial LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2012-002228-34 Sponsor Protocol Number: 2012/1vas Start Date*: 2015-09-30
    Sponsor Name:Diego Caicedo Valdés
    Full Title: Growth hormone (GH) angiogenic effect clinical trial on patients with lower limb critical ischemia. GHAS Study
    Medical condition: Lower limb critical ischemia
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004866 10023034 Ischemia peripheral LLT
    18.0 100000004866 10058069 Critical limb ischemia LLT
    18.0 100000004866 10066920 Leg ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-005789-11 Sponsor Protocol Number: atorv02 Start Date*: 2008-03-11
    Sponsor Name:RUNMC
    Full Title: Does atorvastatin have an acute and prolonged inhibitory effect on ischemia-reperfusion injury in humans in-vivo?
    Medical condition: ischemia-reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023033 Ischemia myocardial LLT
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2007-002520-16 Sponsor Protocol Number: 626 Start Date*: 2007-07-06
    Sponsor Name:Universitätsklinik für klinische Pharmakologie, Medizinische Universität Wien
    Full Title: The effects of post-conditioning and administration of Vitamin C on intramuscular high energy phosphate levels
    Medical condition: ischemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023034 Ischemia peripheral LLT
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2011-005343-27 Sponsor Protocol Number: Metformin-FMD001 Start Date*: 2012-01-27
    Sponsor Name:Radboud University Nijmegen Medical Centre
    Full Title: Can metformin prevent endothelial ischemia and reperfusion injury? The Metformin-FMD trial.
    Medical condition: ischemia and reperfusion injury endothelial dysfunction
    Disease: Version SOC Term Classification Code Term Level
    14.1 10047065 - Vascular disorders 10063837 Reperfusion injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-001564-26 Sponsor Protocol Number: TRIMETA Start Date*: 2022-04-15
    Sponsor Name:FONDAZIONE TOSCANA GABRIELE MONASTERIO
    Full Title: Evaluation of the cardioprotective metabolic effect of trimetazidine in patients with myocardial ischaemia
    Medical condition: Patients with clinical diagnosis of Inducible Myocardial Ischemia (exercise stress test positive for electrocardiographic criteria and /or symptoms)
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004849 10023033 Ischemia myocardial LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-004762-40 Sponsor Protocol Number: Rosudip01 Start Date*: 2007-10-18
    Sponsor Name:Dept. Pharmacology and Toxicology
    Full Title: Rosuvastatin augments dipyridamole induced vasodilation by increased adenosine receptor stimulation
    Medical condition: Ischemia-reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10023034 Ischemia peripheral LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2017-002712-14 Sponsor Protocol Number: AK2017-4 Start Date*: 2017-11-21
    Sponsor Name:Rigshospitalet, Department of Physiology, Nuclear Medicine and PET
    Full Title: Phase II: 68Ga-NODAGA-E[c(RGDyK)]2 Angiogenese PET for imaging angiogenesis in ischaemic heart disease
    Medical condition: Ischaemic heart disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 10007541 - Cardiac disorders 10023024 Ischaemic heart disease LLT
    20.0 10007541 - Cardiac disorders 10008937 Chronic ischemic heart disease, unspecified LLT
    20.0 10007541 - Cardiac disorders 10055218 Ischemic heart disease LLT
    20.0 10007541 - Cardiac disorders 10008936 Chronic ischaemic heart disease, unspecified LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2013-000030-35 Sponsor Protocol Number: RIMINI-Pilot Start Date*: 2013-05-08
    Sponsor Name:University Medical Center Hamburg-Eppendorf
    Full Title: Reduction of Ischemic Myocardium with Ranolazine-Treatment in patients with acute myocardial Ischemia – RIMINI-Pilot-Trial
    Medical condition: CAD with acute ischemia and myocardial dysfunction
    Disease: Version SOC Term Classification Code Term Level
    14.1 10007541 - Cardiac disorders 10028600 Myocardial ischaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-014831-18 Sponsor Protocol Number: fmd/01 Start Date*: 2009-09-25
    Sponsor Name:RUNMC
    Full Title: Short term statin treatment and endothelial dysfunction due to ischemia and reperfusion injury
    Medical condition: ischemia and reperfusion injury endothelial dysfunction
    Disease: Version SOC Term Classification Code Term Level
    12.0 10063837 Reperfusion injury LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001397-15 Sponsor Protocol Number: BMMNC_CLI_001 Start Date*: 2016-06-15
    Sponsor Name:Institut klinické a experimentální medicíny
    Full Title: A prospective, randomized study to compare the effect on tissue oxygenation and clinical outcome of autologous bone marrow-derived mononuclear cell therapy with standard treatment in patients with ...
    Medical condition: Autologous cell therapy (ACT) is new technique for patients with critical limb ischemia and diabetic foot (DF). In our study, the effect of ACT and also the repetitive treatment will be compared wi...
    Disease: Version SOC Term Classification Code Term Level
    19.0 10047065 - Vascular disorders 10034576 Peripheral ischaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-006967-35 Sponsor Protocol Number: HEME 1.0 Start Date*: 2009-02-11
    Sponsor Name:Medizinische Universität Wien, Universitätsklinik für klinische Pharmakologie
    Full Title: The effects of intravenous heme arginate on functional magnetic resonance imaging during ischemia
    Medical condition: ischemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10034578 Peripheral ischemia LLT
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2020-004455-32 Sponsor Protocol Number: IMB101-006 Start Date*: 2021-02-16
    Sponsor Name:Imbria Pharmaceuticals, Inc.
    Full Title: A Randomized, Double-Blind, Placebo-Controlled, Exploratory Study on the Safety, Tolerability, and Pharmacodynamics of IMB-1018972 in Patients with Angina due to Coronary Syndrome
    Medical condition: Stable coronary artery disease (CAD) /Chronic coronary syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) FI (Completed) DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-000377-40 Sponsor Protocol Number: MST-188-07 Start Date*: 2014-11-13
    Sponsor Name:Mast Therapeutics, Inc.
    Full Title: Evaluation of MST-188 in Acute Lower Limb Ischemia: A Phase 2 Randomized Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial Evaluating the Safety and Efficacy Of MST-188 in Subjects with...
    Medical condition: Acute Lower Limb Ischemia
    Disease: Version SOC Term Classification Code Term Level
    17.0 100000004866 10066920 Leg ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Prematurely Ended) CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2010-018584-41 Sponsor Protocol Number: P10.YYY Start Date*: 2010-07-23
    Sponsor Name:LUMC
    Full Title: A phase II study of ARA290 as therapeutic strategy in no-option critical limb ischemia patients.
    Medical condition: Critical Limb Ischemia
    Disease: Version SOC Term Classification Code Term Level
    12.1 10058069 Critical limb ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-017924-18 Sponsor Protocol Number: P10 Start Date*: 2011-01-04
    Sponsor Name:
    Full Title: Efficacy assessment of repeat intramyocardial injection of autologous bone marrow cells in previously responding no-option patients with residual refractory angina pectoris and documented ischemia
    Medical condition: In coronary artery disease atherosclerosis leads to a decrease in lumen diameter of the large epicardial arteries, causing a deficit in blood flow known as ischemia. This ischemia can cause chest p...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-021844-17 Sponsor Protocol Number: 33197 Start Date*: 2010-12-17
    Sponsor Name:Erasmus Medical Centre
    Full Title: Perioperative esmolol infusion for haemodynamic stability during major vascular surgery.
    Medical condition: cardiac complications during and after vascular surgery
    Disease: Version SOC Term Classification Code Term Level
    12.1 10028601 Myocardial ischemia LLT
    Population Age: Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2010-019920-30 Sponsor Protocol Number: THR-PS-02 Start Date*: 2010-06-11
    Sponsor Name:Rigshospitalet,Cardiology Laboratory 2013
    Full Title: A Single center, open, randomized, placebo-controlled study investigating the safety of administration of Ilomedin® in addition to standard treatment in patients having undergone percutaneous coron...
    Medical condition: Percutaneous coronary intervention (PCI) due to an acute ischemic event
    Disease: Version SOC Term Classification Code Term Level
    12.1 10066642 Acute myocardial ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2008-004613-10 Sponsor Protocol Number: IRIVITC2008 Start Date*: 2008-09-12
    Sponsor Name:University College Hospital Galway
    Full Title: The role of the antioxidants ascorbic acid and n-acetylcysteine in the attenuation of ischaemia reperfusion injury in a human model
    Medical condition: Ischaemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063837 Reperfusion injury LLT
    9.1 10063837 Reperfusion injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-000359-33 Sponsor Protocol Number: 0604002 Start Date*: 2007-07-12
    Sponsor Name:CHU Toulouse
    Full Title: PENOMBRE HYPOXIQUE ET ISCHEMIE SEMI-TARDIVE ETUDIEE EN TEP AU 18F-FLUOROMISONIDAZOLE : IMPACT SUR LA RECUPERATION FONCTIONNELLE DANS LES SUITES D’UN AVC ISCHEMIQUE AVEC DEFICIT MOTEUR. Etude de ...
    Medical condition: Accident vasculaire cérébral
    Disease: Version SOC Term Classification Code Term Level
    9.1 10008121 Cerebral ischemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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