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Clinical trials for Knee Injuries

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    14 result(s) found for: Knee Injuries. Displaying page 1 of 1.
    EudraCT Number: 2007-002653-23 Sponsor Protocol Number: 1/07 Start Date*: 2008-09-02
    Sponsor Name:The Police Rehabilitation Centre, Flint House
    Full Title: A pilot for a case control study to evaluate the effects of High Dosage Oxygen Therapy as an adjunct to an established program of physiotherapy and rehabilitation for sub acute soft tissue knee con...
    Medical condition: Sub acute soft tissue injuries to the knee .
    Disease: Version SOC Term Classification Code Term Level
    9.1 10041292 Soft tissue injury NOS LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-000784-16 Sponsor Protocol Number: NCPACI Start Date*: 2016-04-15
    Sponsor Name:Akershus University Hospital
    Full Title: Focal cartilage defects in the knee – A randomized controlled trial comparing Autologous Chondrocyte Implantation with arthroscopic debridement
    Medical condition: Symptomatic focal cartilage defects in the knee
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-003408-21 Sponsor Protocol Number: THO-IM_02-CT Start Date*: 2015-12-09
    Sponsor Name:Thrombotargets Europe
    Full Title: A Phase II/III, randomized, controlled, single blind study to evaluate the haemostatic efficacy and safety of topically applied TT-173 in patients undergoing knee arthroplasty
    Medical condition: Haemostatic effect in patients undergoing knee arthroplasty
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004865 10060663 Surgical hemostasis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-001431-31 Sponsor Protocol Number: EMR700692-007 Start Date*: 2013-05-02
    Sponsor Name:Merck KGaA
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II trial to investigate the efficacy and safety of 30 mcg and 100 mcg AS902330 given as one cycle of three intra-a...
    Medical condition: Knee Cartilage Injury
    Disease: Version SOC Term Classification Code Term Level
    15.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
    EudraCT Number: 2010-023888-17 Sponsor Protocol Number: OMS103-MEN-003 Start Date*: 2011-05-11
    Sponsor Name:Omeros Corporation
    Full Title: A Randomized, Double-Blind, Parallel Group, Vehicle-Controlled Study to Evaluate the Safety and Efficacy of OMS103HP-S Administered in Joint Irrigation Solution to Subjects Undergoing Arthroscopic ...
    Medical condition: Arthroscopic surgery
    Disease: Version SOC Term Classification Code Term Level
    13.1 10042613 - Surgical and medical procedures 10058471 Arthroscopic surgery PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-000909-22 Sponsor Protocol Number: MDS-KET-2004-01 Start Date*: 2004-08-27
    Sponsor Name:MDS Pharma Services
    Full Title: Comparative efficacy and tolerability of a topical ketoprofen TDS patch vs ketoprofen gel in the treatment of acute pain in soft-tissue injuries
    Medical condition: Acute pain in soft-tissue injuries of lower limbs, except toes
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-002963-92 Sponsor Protocol Number: CLRX712A12201 Start Date*: 2020-02-05
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, subject and investigator blinded study investigating the safety, tolerability and preliminary efficacy of 8-week treatment with intra-articular LRX712 to regenerat...
    Medical condition: Cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed) AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-003418-28 Sponsor Protocol Number: CLNA043X2201 Start Date*: 2017-04-18
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, patient and investigator blinded, single dose, Proof of Concept study investigating the safety, tolerability and preliminary efficacy of intra-articular LNA043 in ...
    Medical condition: Acute cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-015532-14 Sponsor Protocol Number: EMR700692-003 Start Date*: 2010-01-22
    Sponsor Name:Merck Serono S.A. - Geneva
    Full Title: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II trial to investigate the efficacy and safety of weekly intra-articular (i.a.) injections of 10, 30, and 100 µg o...
    Medical condition: Knee Cartilage Injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10007710 Cartilage injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed) HU (Completed) SI (Completed) BG (Prematurely Ended) AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-004613-10 Sponsor Protocol Number: IRIVITC2008 Start Date*: 2008-09-12
    Sponsor Name:University College Hospital Galway
    Full Title: The role of the antioxidants ascorbic acid and n-acetylcysteine in the attenuation of ischaemia reperfusion injury in a human model
    Medical condition: Ischaemia reperfusion injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10063837 Reperfusion injury LLT
    9.1 10063837 Reperfusion injury PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004052-30 Sponsor Protocol Number: CLNA043X2202 Start Date*: 2017-04-28
    Sponsor Name:Novartis Pharma AG
    Full Title: A randomized, placebo-controlled, patient and investigator blinded, Proof of Concept study investigating the safety, tolerability and preliminary efficacy of multiple intra-articular LNA043 injecti...
    Medical condition: Acute cartilage injuries
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10031161 Osteoarthritis PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed) CZ (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2011-006270-13 Sponsor Protocol Number: XCEL-MEN-01 Start Date*: 2013-01-08
    Sponsor Name:Banc de Sang i Teixits
    Full Title: A phase I-IIa safety and efficacy pilot clinical trial of intraarticular administration of autologous mesenchymal stem cells in meniscus injury
    Medical condition: Degenerative meniscal lesion
    Disease: Version SOC Term Classification Code Term Level
    15.0 10028395 - Musculoskeletal and connective tissue disorders 10069364 Meniscal degeneration PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2020-005742-42 Sponsor Protocol Number: SCALA Start Date*: 2023-04-13
    Sponsor Name:Groupement de Coopération Sanitaire Ramsay Générale de Santé pour l’Enseignement et la Recherche
    Full Title: Effect of botulinum toxin on hamstring contracture and the occurrence of cyclops syndrome after anterior cruciate ligament reconstruction
    Medical condition: Cyclops syndrome
    Disease: Version SOC Term Classification Code Term Level
    20.0 10028395 - Musculoskeletal and connective tissue disorders 10058029 Arthrofibrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-005802-29 Sponsor Protocol Number: RD/505/06 Start Date*: 2007-06-26
    Sponsor Name:Gwent Healthcare NHS Trust
    Full Title: Postoperative analgesia for Total knee replacement: A comparision between intrathecal morphine and peripheral nerve block.
    Medical condition: Postoperative analgesia for Total Knee Replacement
    Disease: Version SOC Term Classification Code Term Level
    14.0 10007541 - Cardiac disorders 10007521 Cardiac arrhythmias HLGT
    14.0 10022117 - Injury, poisoning and procedural complications 10029177 Nerve damage LLT
    14.0 10029205 - Nervous system disorders 10010914 Convulsions LLT
    14.0 10038738 - Respiratory, thoracic and mediastinal disorders 10038678 Respiratory depression PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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