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Clinical trials for Morphine

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    485 result(s) found for: Morphine. Displaying page 1 of 25.
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    EudraCT Number: 2005-002308-40 Sponsor Protocol Number: IN Morphine II Start Date*: 2005-08-19
    Sponsor Name:University of Plymouth
    Full Title: Evaluation of Intranasal (IN) Morphine Sulphate as a Paramedic Administered Analgesic for Children in the Pre-Hospital Environment
    Medical condition: This research hopes to bridge the gap between in-hospital diamorphine and pre-hospital IV morphine by developing IN morphine for administration to children between 3 and 14 years old. This will all...
    Disease:
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2009-014892-31 Sponsor Protocol Number: MAIVECMOPAIN Start Date*: 2009-11-10
    Sponsor Name:ErasmusMC - Sophia
    Full Title: Morphine intravenous vs. Paracetamol intravenous in children on ECMO
    Medical condition: Patients treated with Extra Corporal Membrane Oxygenation (ECMO) receive morphine as standardised analgesic drug. Morphine is associated with several side effects. In these patients a non-opioid dr...
    Disease:
    Population Age: Preterm newborn infants, Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-005087-14 Sponsor Protocol Number: CPP-401 Start Date*: 2008-11-12
    Sponsor Name:Centre Paul Papin
    Full Title: Comparison of 2 morphine administration’s mode using Pump IntraThecal (IDDS)for Analgesia in patients with Cancer pain, resistant to conventional antalgic treatment
    Medical condition: Patients with intractable cancer pain, either uncontrolled with standard analgesia , or undergoing severe side effects due to analgesia . Patients undergo implantation of a Medtronic intrathecal pu...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    9.1 10059050 Intractable pain LLT
    Population Age: Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001143-40 Sponsor Protocol Number: OBEMO1EXT Start Date*: 2016-06-22
    Sponsor Name:Therapeutic Research Unit
    Full Title: Long-term effects of Roux-en-Y Gastric Bypass on morphine exposure after oral administration of immediate release morphine, in comparison with subjects without surgery
    Medical condition: Subjects volunteers who undergone Roux-en-Y gastric bypass (RYGB) for at least 48 months and control subjects matched for BMI, age and sex
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-002623-29 Sponsor Protocol Number: Lundbeckstudy2016 Start Date*: 2016-08-29
    Sponsor Name:Aalborg Universitets Hospital
    Full Title: The Effect of Morphine on the Human Central Nervous System
    Medical condition: Healthy volunteers (Brain response to i.v. morphine)
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-006579-19 Sponsor Protocol Number: MP-EG-002 Start Date*: 2007-04-19
    Sponsor Name:Egalet a/s
    Full Title: A double-blind, randomized, 2-way cross-over, phase II, efficacy trial in cancer patients to assess the overall efficacy, patient preference, morphine related side effect profile and safety of the ...
    Medical condition: cancer patients
    Disease: Version SOC Term Classification Code Term Level
    8.1 10058019 Cancer pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: LT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-005903-34 Sponsor Protocol Number: KKSMUW2011-09 Start Date*: 2012-05-04
    Sponsor Name:G. L. Pharma GmbH
    Full Title: Phase II, single centre, double blinded, cross-over dose confirmation study using two morphine-naloxone i.v. solutions
    Medical condition: Treatment of opioid dependence
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2007-005619-24 Sponsor Protocol Number: NL-MAIV-10-2007 Start Date*: 2007-12-06
    Sponsor Name:ErasmusmMC/ Sophia Children Hospital
    Full Title: Morphine intravenous vs. Acetaminophen intravenous in neonates and young infants undergoing major non-cardiac surgery.
    Medical condition: Patients after non-cardiac thoracic or abdominal major surgery receive Morphine as pain relief medication whereas this is associated with Morphine related side effects. In these patients a non-opio...
    Disease:
    Population Age: Newborns, Infants and toddlers, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-003722-18 Sponsor Protocol Number: 24862486 Start Date*: 2007-12-10
    Sponsor Name:St. Antonius Ziekenhuis
    Full Title: Randomized clinical trial of the optimization of procedural pain control in Intensive Care patients
    Medical condition: all patients admitted to the ICU of the St. Antonius hospital (>18 years old)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2019-003571-19 Sponsor Protocol Number: RBH2019/001 Start Date*: 2020-05-21
    Sponsor Name:Royal Brompton and Harefield NHS Foundation Trust
    Full Title: PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough
    Medical condition: Idiopathic pulmonary fibrosis
    Disease: Version SOC Term Classification Code Term Level
    21.1 10038738 - Respiratory, thoracic and mediastinal disorders 10021240 Idiopathic pulmonary fibrosis PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2015-004380-37 Sponsor Protocol Number: 0 Start Date*: 2016-05-03
    Sponsor Name:University Hospital Sjaelland, Roskilde,Palliative Unit
    Full Title: Oral morphine drops for rapid treatment of dyspnea in palliative cancer patients
    Medical condition: Morphine drops for palliation of breathlessness in palliative cancer patients
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-003427-14 Sponsor Protocol Number: AHUS_PAL_21_01 Start Date*: 2021-12-20
    Sponsor Name:Akershus University Hospital
    Full Title: A randomized controlled trial of subcutaneous versus intravenous morphine when switching from oral to parenteral route in palliative cancer patients
    Medical condition: Cancer pain not responding to oral opioids in palliative cancer patient, where switching to the parenteral route is indicated.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-001783-21 Sponsor Protocol Number: 3288 Start Date*: 2012-07-11
    Sponsor Name:Childrens's Research Institute
    Full Title: Optimizing Pain Treatment in Pre-Term Neonates
    Medical condition: Critically Ill Premature Neonates between 23 and 32 weeks of gestation who are receiving morphine as part of their routine medical management of pain or other medically indicated condition for whic...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10056350 Pain management PT
    Population Age: Preterm newborn infants, Under 18 Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2004-004620-12 Sponsor Protocol Number: dyspnoea1 Start Date*: 2005-01-14
    Sponsor Name:Royal Marsden Hospital
    Full Title: Assessment of normal release morphine in the management of dyspnoea
    Medical condition: Breathlessness of any cause in cancer patients are identified and treated with normal release morphine which has been shown to be both effective and safe.The idea of the trial is to see if there wi...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-006846-24 Sponsor Protocol Number: HTA074801 Start Date*: 2009-02-27
    Sponsor Name:North West London Hospitals NHS Trust
    Full Title: An Evaluation of the Effectiveness of Ibuprofen and Morphine for Acute Pain in Sickle Cell Disease
    Medical condition: Sickle Cell Disease
    Disease:
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-001814-34 Sponsor Protocol Number: OPI 04/006 Start Date*: 2006-09-12
    Sponsor Name:The Norwegian University of Science and Technology
    Full Title: Effects of hypothermia on the disposition of morphine, fentanyl, midazolam and propofol in intensive care unit patients
    Medical condition: Patients treated with therapeutic hypothermia (33-34 °C) and a control group of normothermic patients matched on sex, age and duration of morphine infusion.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2010-023844-34 Sponsor Protocol Number: ParCS Start Date*: 2011-06-30
    Sponsor Name:Sint Maartenskliniek
    Full Title: Effectiveness and safety of parecoxib in children undergoing scoliosis surgery compared to placebo: a double-blinded randomised controlled trial
    Medical condition: Postoperative pain in children after scoliosis surgergy (spinal fusion). The morphine consumption on the first two postoperative days will be assessed. Children: <18 years old, ASA I or II
    Disease: Version SOC Term Classification Code Term Level
    12.1 10039727 Scoliosis surgery PT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-002239-97 Sponsor Protocol Number: P060402 Start Date*: 2007-11-22
    Sponsor Name:ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
    Full Title: Ketamine en association avec une PCA morphine dans le traitement analgésique postopératoire de patients opérés de prothèse totale de hanche (PTH)
    Medical condition: Patients opérés d'une prothèse totale de hanche
    Disease: Version SOC Term Classification Code Term Level
    8.1 10036276 Postoperative analgesia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2022-001410-20 Sponsor Protocol Number: NL81154.091.22 Start Date*: 2022-09-21
    Sponsor Name:Radboud university medical center
    Full Title: Determining the clinical relevance of the interaction between enzalutamide and the opioid morphine and the DOAC edoxaban to improve rational pharmacological care of patients with prostate cancer
    Medical condition: Prostate cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2021-002625-20 Sponsor Protocol Number: SC052021 Start Date*: 2021-08-31
    Sponsor Name:University Hospitals Leuven
    Full Title: Intrathecal morphine administration for minimally invasive pancreatic surgery: A double blind, prospective randomized placebo-controlled trial.
    Medical condition: postoperative pain treatment after minimally invasive pancreatic surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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