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Clinical trials for N-acetylcysteine (NAC)

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
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    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

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    37 result(s) found for: N-acetylcysteine (NAC). Displaying page 1 of 2.
    1  2  Next»
    EudraCT Number: 2011-002093-23 Sponsor Protocol Number: 1.01 Start Date*: 2011-09-21
    Sponsor Name:University of Tartu
    Full Title: Bioavailability of oral N-acetylcysteine in different intensive care unit patient groups
    Medical condition: Severe neurotrauma, severe pulmonary infections and severe gastrointestinal disease (eg peritonitis, pancreatitis, ileus, major abdominal surgery etc). Need for liquefaction of viscous sputum
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: EE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-005154-35 Sponsor Protocol Number: 131115 Start Date*: 2016-02-22
    Sponsor Name:University Hospital Brussels (UZ Brussel)
    Full Title: N-acetylcysteine for the treatment of cannabis dependence: working mechanisms
    Medical condition: Cannabis dependence
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: BE (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2007-002787-95 Sponsor Protocol Number: WP-07-148 Start Date*: 2008-01-03
    Sponsor Name:Department of Pulmonology, Rijnstate Hospital
    Full Title: A randomized double-blind study of N-Acetylcysteine vs. placebo to Prevent Neurotoxicity induced by Platinum containing chemotherapy in patients treated for (Non)Small Cell Lung Cancer and Malignan...
    Medical condition: Cisplatin-induced peripheral neuropathy will be investigated.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10036109 Polyneuropathy due to drugs LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2019-000242-35 Sponsor Protocol Number: 18CT0003 Start Date*: Information not available in EudraCT
    Sponsor Name:E-Pharma Trento SpA
    Full Title: Randomized, double blind, double dummy, parallel-groups, clinical trial on efficacy and safety of ibuprofen/N-acetylcysteine fixed dose combination vs. individual components (ibuprofen and N-acetyl...
    Medical condition: symptomatic non-complicated upper respiratory tract infections
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004862 10046309 Upper respiratory tract infections HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2005-005809-38 Sponsor Protocol Number: NACP1 Start Date*: 2006-12-08
    Sponsor Name:Research & Development Department, Addenbrookes Hospital
    Full Title: Does prophylactic N acetylcysteine reduce the incidence of contrast nephropathy in patients undergoing peripheral angiography
    Medical condition: We will use N acetylcystiene prophylactically in patient undergoing peripheral angiography at the Cambridge Vascular Unit at Addenbrooke's Hospital in order to prevent renal injury. Patients underg...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2004-001098-25 Sponsor Protocol Number: NAC-E-21 Start Date*: 2004-08-23
    Sponsor Name:Zambon SA
    Full Title: N-Acetylcisteine (NAC) effect on the inmunologycal system
    Medical condition: Postmenopausal health woman aged more than 50 years
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2005-003651-12 Sponsor Protocol Number: NAC-E-23 Start Date*: 2005-11-11
    Sponsor Name:ZAMBON, S.A.
    Full Title: NAC EFFECT ON OXIDATIVE STRESS AND MUSCLE FUNCTION IN COPD PATIENTS. Efecto de NAC en estrés oxidativo y función muscular en pacientes con EPOC
    Medical condition: CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD).
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2016-003144-36 Sponsor Protocol Number: NAC.TEP16 Start Date*: 2020-11-18
    Sponsor Name:Radboud University Medical Centre
    Full Title: Pilot study: postoperative pain reduction by pre emptive N-Acetylcysteine
    Medical condition: postoperative pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2008-001620-31 Sponsor Protocol Number: CZB/4/622 Start Date*: 2009-09-14
    Sponsor Name:NHS Highland
    Full Title: Glutathione Status in Platelets From Patients With Type 2 Diabetes: Therapeutic Potential of N-acetylcysteine to Help Prevent Platelet Hyperaggregability
    Medical condition: Platelet Aggregation in type 2 diabetes
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2014-004522-17 Sponsor Protocol Number: NACAHvs.1.1 Start Date*: 2015-03-06
    Sponsor Name:Imperial College London & Imperial College Healthcare NHS Trust
    Full Title: The mechanism of action of N-ACetylcysteine for reducing the risk of Infection in Alcoholic Hepatitis
    Medical condition: Alcoholic hepatitis
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2018-003232-80 Sponsor Protocol Number: 2017-71 Start Date*: 2019-03-04
    Sponsor Name:ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE
    Full Title: RENACTIF: Reduction of the Thrombotic Phenotype in Renal Insufficiency With N-AcetylCysteine : A Randomized, Double-blind, Placebo-controlled, Cross-over Trial
    Medical condition: Chronic Kidney Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-002531-30 Sponsor Protocol Number: 20-079 Start Date*: 2020-08-05
    Sponsor Name:CHU CAEN Normandie
    Full Title: ETUDE DE TOLERANCE DE LA N-ACETYLCYSTEINE POUR LA THROMBOLYSE A LA PHASE AIGUË DE L’INFARCTUS CEREBRAL
    Medical condition: Patients atteints d’un infarctus cérébral non lacunaire bénéficiant d’un traitement par fibrinolyse intraveineuse (+/- thrombectomie mécanique).
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004852 10042244 Stroke LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-002825-10 Sponsor Protocol Number: NACoV Start Date*: 2022-01-17
    Sponsor Name:FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS UNIVERSITA' CATTOLICA DEL SACRO CUORE
    Full Title: Exploratory efficacy of N-Acetylcysteine in patients with history of COVID-19 (NACoV)
    Medical condition: patients with history of SARS-Cov-2 infection and residual respiratory impairment
    Disease: Version SOC Term Classification Code Term Level
    23.0 10021881 - Infections and infestations 10058686 Bilateral pneumonia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2008-006837-28 Sponsor Protocol Number: PML_DOC_0804 Start Date*: 2008-12-08
    Sponsor Name:University Hospital Antwerp; Department Respiratory Medicine
    Full Title: Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N-acetylcysteine on small airways and on inflammation and oxidative stress in COPD pat...
    Medical condition: Chronic Obstructive Pulmonary Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-003946-13 Sponsor Protocol Number: PML_NAC_01 Start Date*: 2007-09-05
    Sponsor Name:University Hospital Antwerp; Department Respiratory Medicine
    Full Title: Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N acetylcysteine on small airways and on inflammation and oxidative stress in COPD pat...
    Medical condition: Chronic Obstructive Pulmonary Disease
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2017-000246-21 Sponsor Protocol Number: PP100-001 Start Date*: 2017-04-25
    Sponsor Name:PledPharma AB
    Full Title: A Randomised Open Label Exploratory, Safety and Tolerability Study with PP100-01 in Patients Treated with the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose
    Medical condition: The objective of this study is to develop a therapeutic regimen for paracetamol/acetaminophen overdose (POD) where a novel NAC 12hr regime is combined with a superoxide dismutase (SOD) mimetic, PP1...
    Disease: Version SOC Term Classification Code Term Level
    20.0 10022117 - Injury, poisoning and procedural complications 10033295 Overdose PT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-001677-15 Sponsor Protocol Number: 08/H0808/2 Start Date*: 2008-07-21
    Sponsor Name:King's College Hospital NHS Foundation Trust
    Full Title: The effect of intraoperative N-acetylcysteine on hepatocellular injury during laparoscopic bariatric surgery. A randomised controlled trial.
    Medical condition: Non-Alcoholic Fatty Liver Disease in patients undergoing weight-loss (bariatric) surgery
    Disease: Version SOC Term Classification Code Term Level
    9.1 10031743 Other chronic nonalcoholic liver disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2012-005435-87 Sponsor Protocol Number: FIBHGM-ECNC002-2012 Start Date*: 2013-02-14
    Sponsor Name:Fundación para la Investigación Biomédica Hospital Gregorio Marañón
    Full Title: EFFECT OF ADJUVANT TREATMENT WITH N - ACETYLCYSTEINE DURING 48 WEEKS ON THE LOSS OF GREY SUBSTANCE AND OXIDATIVE METABOLISM IN PATIENTS WITH EARLY ONSET PSYCHOTIC EPISODES: BLIND, PLACEBO-CONTROLLE...
    Medical condition: PATIENTS WITH EARLY ONSET PSYCHOTIC EPISODES
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10061920 Psychotic disorder PT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-008317-20 Sponsor Protocol Number: AGO/2008/014 Start Date*: 2009-11-13
    Sponsor Name:University Hospital Ghent
    Full Title: The effect of inhaled N-Acetylcysteine compared to normal saline on sputum rheology and lung function
    Medical condition: Cystic Fibrosis
    Disease: Version SOC Term Classification Code Term Level
    12.0 10011762 Cystic fibrosis LLT
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-004892-37 Sponsor Protocol Number: NL41205.018.12 Start Date*: 2013-03-21
    Sponsor Name:Academic Medical Center
    Full Title: N-Acetylcysteine in patients with Sickle Cell Disease: Reducing the incidence of daily life pain in patients with sickle cell disease
    Medical condition: Sickle Cell
    Disease: Version SOC Term Classification Code Term Level
    15.1 100000004850 10040643 Sickle cell crisis LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended) BE (Completed) GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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