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Clinical trials for Nociception

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    15 result(s) found for: Nociception. Displaying page 1 of 1.
    EudraCT Number: 2014-005701-20 Sponsor Protocol Number: ANST2015_1 Start Date*: 2015-05-20
    Sponsor Name:Leiden University Medical Center
    Full Title: Shifting pain modulation towards anti-nociceptivity: Mechanism-specific pharmacological prevention of post sternotomy pain: the MASTER study
    Medical condition: chronic pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-007405-37 Sponsor Protocol Number: 1497/08 Start Date*: 2009-03-07
    Sponsor Name:POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI
    Full Title: Multicenter, not-for-profit study to evaluate tolerability, safety of tramadol once-a-day in older patients with dementia and difficulty to verbalize
    Medical condition: Pain in older patients with dementia
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050533 Pain assessment LLT
    9.1 10000428 Ache NOS LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2021-002712-30 Sponsor Protocol Number: FPS-SMG-2021-02 Start Date*: 2021-10-05
    Sponsor Name:FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD
    Full Title: PHASE III, RANDOMISED, DOUBLE-BLIND, CLINICAL TRIAL TO DETERMINE THE ROLE OF MAGNESIUM SULPHATE IN ADDUCTOR CANAL BLOCK IN ARTHROSCOPIC KNEE SURGERY
    Medical condition: Pain in arthroscopic anterior cruciate ligament reconstruction surgery.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-016907-41 Sponsor Protocol Number: fMRT-Nociception Start Date*: 2012-09-10
    Sponsor Name:Charité, Universitätsmedizin Berlin
    Full Title: Investigation of nociceptive and antinociceptive mechanisms under anesthesia using fMRI, EEG and noxious reflexes
    Medical condition: This is a CT including only healthy volunteers. The aim of the study is to investigate the effect of a commonly used anesthetic drug in clinical concentrations on nociceptive and antinociceptive me...
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2011-005086-20 Sponsor Protocol Number: CHDR1117 Start Date*: 2011-11-22
    Sponsor Name:Centre for Human Drug Research (CHDR)
    Full Title: Effects of paracetamol on nociception in adolescents.
    Medical condition: Nociceptive pain (disorders)
    Disease:
    Population Age: Adolescents, Under 18 Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2022-001603-40 Sponsor Protocol Number: P22-XXX Start Date*: 2022-07-18
    Sponsor Name:Leiden University Medical Center
    Full Title: Combined effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on breathing: an exploratory study in healthy volunteers the POLO study
    Medical condition: Healthy Volunteers
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2019-000647-27 Sponsor Protocol Number: Ibu19 Start Date*: 2019-12-18
    Sponsor Name:Dicofarm S.p.A.
    Full Title: Evaluation of efficacy and bioavailability of a new pediatric formulation based on ibuprofen lysinate vs ibuprofen in the management of pain in children
    Medical condition: Pain on an inflammatory basis (otitis and otomastoiditis, adenite, cellulite, arthritis) and post-operative pain
    Disease: Version SOC Term Classification Code Term Level
    21.0 10022891 - Investigations 10050533 Pain assessment PT
    20.1 10022891 - Investigations 10063374 Pain scale LLT
    Population Age: Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2016-002824-98 Sponsor Protocol Number: ANE_HEPUNOX Start Date*: 2016-10-20
    Sponsor Name:Fundació Hospital Vall Hebron Institut de Recerca
    Full Title: Comparison of three techniques in the management of the postoperatory acute pain, after a general anesthesia based on the control of the nociception.
    Medical condition: Acute postoperative pain
    Disease: Version SOC Term Classification Code Term Level
    19.0 100000004865 10002323 Anesthesia general LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2021-002725-23 Sponsor Protocol Number: FPS-ROP-2021-03 Start Date*: 2021-11-18
    Sponsor Name:Fundación Pública Andaluza Progreso y Salud
    Full Title: ULTRASOUND-GUIDED ERECTOR SPINAE BLOCKADE AS PART OF MULTIMODAL ANALGESIA IN LUMBOSACRAL SURGERY: A PROSPECTIVE RANDOMISED STUDY.
    Medical condition: Pain in lumbosacral surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-005043-86 Sponsor Protocol Number: 1308143 Start Date*: 2014-03-21
    Sponsor Name:CHU de Saint-Etienne
    Full Title: Reactivity of the autonomic nervous system after a nociceptive stress in the newborn: Interest of sucrose and non-nutritive sucking.
    Medical condition:
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004848 10051566 Fasting blood glucose LLT
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2018-003144-23 Sponsor Protocol Number: 2017/81 Start Date*: 2018-09-05
    Sponsor Name:University of Liège
    Full Title: Treating severe brain-injured patients with apomorphine : a behavioural and neuroimaging study
    Medical condition: Disorders of consciousness
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003172-36 Sponsor Protocol Number: 29.06.2011 Start Date*: 2011-10-07
    Sponsor Name:Department of Anaesthesia, Tampere University Hospital
    Full Title: Arousal reaction during desflurane anaesthesia
    Medical condition: The patients who undergo abdominal surgeries (laparotomy or laparoscopy) under desflurane anaesthesia will be investigated.
    Disease: Version SOC Term Classification Code Term Level
    14.0 10042613 - Surgical and medical procedures 10018060 General anaesthesia PT
    14.0 10022891 - Investigations 10014275 EEG LLT
    14.0 10029205 - Nervous system disorders 10002091 Anaesthesia PT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2021-006334-39 Sponsor Protocol Number: CP130-1016 Start Date*: 2022-01-10
    Sponsor Name:Trevena Inc
    Full Title: Protocol title should be: A randomised, double-blind, placebo-controlled, dose-ranging partial-block crossover study to investigate the effect of intravenous oliceridine on CNS functioning and noc...
    Medical condition: Acute Pain
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004867 10066714 Acute pain LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: (No results available)
    EudraCT Number: 2012-000680-24 Sponsor Protocol Number: POSTrct_ORTGH Start Date*: 2012-05-25
    Sponsor Name:Academisch Medisch Centrum
    Full Title: Pain management after operative treatment of extremity fractures, a randomized clinical trial
    Medical condition: Patient satisfaction with pain relief and pain intensity (Numeric Rating Scale) will be investigated. Also to find predictors we will investigate: age, sex, trauma-site, fracture type, AIS score, ...
    Disease: Version SOC Term Classification Code Term Level
    17.1 100000004859 10024956 Lower limb fractures HLT
    19.1 100000004865 10036236 Postoperative pain relief LLT
    19.1 100000004848 10033762 Paracetamol LLT
    17.1 100000004859 10046292 Upper limb fractures HLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2020-002802-21 Sponsor Protocol Number: PRIMERA001 Start Date*: 2020-12-18
    Sponsor Name:Erasmus Medical Center
    Full Title: PeRsonalIzed MEdicine in Rheumatoid Arthritis (PRIMERA trial): a multicenter, single-blinded, randomized controlled trial comparing usual care with a tailor-made approach
    Medical condition: Rheumatoid arthritis according to 2010 criteria
    Disease: Version SOC Term Classification Code Term Level
    23.1 100000004859 10040107 Seropositive rheumatoid arthritis LLT
    23.1 100000004859 10062719 Seronegative rheumatoid arthritis LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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