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Clinical trials for Opiate

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44335   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    121 result(s) found for: Opiate. Displaying page 1 of 7.
    1  2  3  4  5  6  7  Next»
    EudraCT Number: 2006-001384-30 Sponsor Protocol Number: 05/010/SAN Start Date*: 2006-08-01
    Sponsor Name:Brighton and Sussex Universities Hospitals Trust Research and Development Directorate
    Full Title: Standard vs reduced dose naloxone for the reversal of opiate overdose. Does dose modification increase the likelihood of reaching hospital and entering a substance misuse programme?
    Medical condition: Accidental, recreational heroin (and other opiate) overdose.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-004912-30 Sponsor Protocol Number: aprepitant1 Start Date*: 2008-07-31
    Sponsor Name:Karolinska Institutet
    Full Title: Modulation of opiate reward by NK1 antagonism: A laboratory based proof of concept study
    Medical condition: opiate abuse
    Disease: Version SOC Term Classification Code Term Level
    9.1 10039004 Reversal of opiate activity LLT
    9.1 10012346 Dependence on opiates LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-003720-11 Sponsor Protocol Number: M1084997 Start Date*: 2006-09-08
    Sponsor Name:GE Healthcare Finland Oy
    Full Title: Comparison of the quality of anesthesia and intraoperative stress responses to noxious stimulus with high opiate, low hypnotic versus low opiate high hypnotic drug administration during anesthesia ...
    Medical condition: Comparing the intra-operative stress responses to noxious stimulus with high opiate, low hypnotic versus low opiate high hypnotic drug administration during anesthesia. Back surgery
    Disease: Version SOC Term Classification Code Term Level
    8.1 10049130 Back surgery LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: BE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-001216-23 Sponsor Protocol Number: Clockstop 1, Start Date*: 2007-06-20
    Sponsor Name:Phoenux AG
    Full Title: Phase I Studie bei substituirten chronischen Opiatgebrauchern zur Aufhebung zusätzlicher Opioidwirkungen einer weiteren Opiatgebrauchern zur Aufhebung zusätlicher Opioidwirkungen einer weiteren Opi...
    Medical condition: Opiate addiction
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019935 Heroin addiction LLT
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2020-000595-37 Sponsor Protocol Number: 1111111 Start Date*: 2020-12-02
    Sponsor Name:Fakultní nemocnice v Motole
    Full Title: Pharmacokinetics and pharmacodynamics of levobupivacaine during continuous caudal epidural analgesia in newborns
    Medical condition: The primary aim of study is to determine PK and PD of levobupivacaine in newborns (premature included). And discover or decline of LA cumulation. The secondary aim of the study is to obtain enough ...
    Disease:
    Population Age: Preterm newborn infants, Newborns, Under 18 Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002352-41 Sponsor Protocol Number: HDL07-01 Start Date*: 2007-08-21
    Sponsor Name:Helsingin Diakonissalaitos
    Full Title: Lyhyt ja pitkä buprenorfiini-naloksoni -hoito suonensisäisen buprenorfiiniriippuvuuden vieroitushoidossa. Satunnaistettu kontrolloitu tutkimus
    Medical condition: Opiaattiriippuvuus, buprenorfiinin suonensisäinen väärinkäyttö
    Disease: Version SOC Term Classification Code Term Level
    9.1 10030882 Opiate withdrawal symptoms LLT
    9.1 10064475 Opiate dependency relapse LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: FI (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2007-006523-12 Sponsor Protocol Number: 19521952 Start Date*: 2009-08-12
    Sponsor Name:Julio Bobes
    Full Title: Mejora de la efectividad de los tratamientos de mantenimiento con naltrexona en adictos a opiáceos con la adicción de buprenorfina sublingual. Improvement of naltrexone maintenance treatment effec...
    Medical condition: Dependencia de opiáceos. Opiate dependence.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012346 Dependence on opiates LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-011348-20 Sponsor Protocol Number: SPINO-PERI Start Date*: 2009-04-23
    Sponsor Name:AZIENDA OSPEDALIERA ISTITUTI CLINICI DI PERFEZIONAMENTO DI MILANO
    Full Title: COMPARISON BETWEEN DIFFERENT DOSES OF OPIATE ADMINISTERED IN SPINAL WAY IN LABOUR: CHANGES IN CARDIOTOCOGRAPHIC TRACE.
    Medical condition: Pregnant women who want to receive analgesia during labour
    Disease: Version SOC Term Classification Code Term Level
    9.1 10036585 SOC
    Population Age: Adults Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-004319-20 Sponsor Protocol Number: 55218 Start Date*: 2017-06-29
    Sponsor Name:Maasstad Ziekenhuis
    Full Title: Spinal Morphine in Robotic Assisted Radical Prostatectomy
    Medical condition: Robotic Assisted Radical Prostatectomy
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-004496-10 Sponsor Protocol Number: NRL011-01/2004 Start Date*: 2005-04-05
    Sponsor Name:Norgine International Limited
    Full Title: A Phase 2a double blind, randomised, placebo controlled, two dose study to determine the effect of orally administered methylnaltrexone (MNTX) in preventing post-operative opiate induced constipati...
    Medical condition: Coated MNTX is being developed for the prevention of constipation in patients taking opioids for hip and knee replacement surgery for analgesia (pain relief). This drug is as yet unlicensed for use...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-010360-41 Sponsor Protocol Number: BU0902 Start Date*: 2009-06-03
    Sponsor Name:Reckitt Benckiser Healthcare (UK) Limited
    Full Title: A multicentre, randomised, open-label, active-controlled trial of the effectiveness of buprenorphine/naloxone in reducing intravenous buprenorphine misuse in France
    Medical condition: For both compounds, substitution treatment for opioid drug dependence, adult subjects with a diagnosis of major heroin dependence. Only for Suboxone, the intention of naloxone is to deter the intra...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012346 Dependence on opiates LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2005-005226-31 Sponsor Protocol Number: 1.1 Start Date*: 2006-04-24
    Sponsor Name:University of Oxford, Nuffield Department of Medicine
    Full Title: TIME 1 The First Therapeutic Intervention in Malignant Pleural Effusion Trial (TIME1) A 2 x 2 randomised factorial trial to assess whether non-steroidal anti-inflammatory analgesics and small bore...
    Medical condition: Malignant pleural effusion
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2007-007479-18 Sponsor Protocol Number: PROTESI Start Date*: 2008-01-23
    Sponsor Name:OSPEDALE S. RAFFAELE
    Full Title: Postoperative analgesia in major ortopedic surgery: continuos epidural perfusion with laevobupivacaine 0.125% vs continuos epidural perfusion with laevobupivacaine 0.125% + sufentanil 0.5 gamma/ml.
    Medical condition: patients undergoing to surgery for hip and knee prothesis (first implantation)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10028395 Musculoskeletal and connective tissue disorders SOC
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2014-000354-11 Sponsor Protocol Number: ABR47613 Start Date*: 2021-04-30
    Sponsor Name:Radboud UMC
    Full Title: The Efficacy of Ibogaine in the Treatment of Addiction; an open label, single fixed dose pilot-study of the efficacy of ibogaine in opioid-dependent subjects
    Medical condition: Dependence on opiate narcotics
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2011-004775-36 Sponsor Protocol Number: DETOX-11 Start Date*: 2012-01-30
    Sponsor Name:GET SRL
    Full Title: ''A Phase III, multicenter, open-label study, to evaluate the efficacy and safety of different dosage regimens of 0.2 mg lofexidine hydrochloride (DIMATEX) in the treatment of withdrawal symptoms d...
    Medical condition: Oppiate addicts(heroin, methadone and buprenorphine)
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10032707 Other specified drug dependence, continuous use LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2011-001510-33 Sponsor Protocol Number: RR11/9781 Start Date*: 2012-08-02
    Sponsor Name:Leeds Teaching Hospitals R and D department
    Full Title: The Efficacy of Continuous Intra-articular Infusion of Local Anaesthetic Agent following Elective Primary Hip Arthroplasty
    Medical condition: Pain relief after surgery for patients who have undergone hip replacement due to osteoarthritis or other hip pathology
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-003035-35 Sponsor Protocol Number: HS-14-499 Start Date*: 2015-11-09
    Sponsor Name:Braeburn Pharmaceuticals
    Full Title: An Open-Label Multicenter Study Assessing the Long-Term Safety of a Once-Weekly and Once-Monthly, Long-Acting Subcutaneous Injection Depot of Buprenorphine (CAM2038) in Adult Outpatients with Opioi...
    Medical condition: Opioid Use Disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) SE (Completed) DK (Completed) HU (Completed)
    Trial results: View results
    EudraCT Number: 2015-000229-35 Sponsor Protocol Number: 2015/01 Start Date*: 2016-11-03
    Sponsor Name:Beaumont Hospital
    Full Title: A prospective randomised control trial comparing local anaesthetic subcutaneous wound injection versus local anaesthetic wound percolation in distal forearm fractures
    Medical condition: Fracture of distal radius or ulna
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-018450-12 Sponsor Protocol Number: 706079098 Start Date*: 2010-08-18
    Sponsor Name:Agneta Blanck Olerup
    Full Title: Optimising pain control after caesarean section - an evaluation if oxycodone can replace morphine and low potency opioids postoperatively.
    Medical condition: Pain management after elective cesarean section.
    Disease: Version SOC Term Classification Code Term Level
    12.1 10036276 Postoperative analgesia LLT
    Population Age: Newborns, Under 18, Adults Gender: Female
    Trial protocol: SE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003047-22 Sponsor Protocol Number: RB-UK-11-0017 Start Date*: 2012-01-12
    Sponsor Name:Reckitt Benckiser Pharmaceuticals
    Full Title: A Randomised, Double-Blind, Double-Dummy, Active-Drug-Controlled, Parallel-Group, Multicentre Acceptability and Safety Study of the Transfer from Subutex®/Suboxone® to RBP-6300 in Opioid-Dependent ...
    Medical condition: Maintenance/substitution agent for the treatment of opioid dependence
    Disease: Version SOC Term Classification Code Term Level
    14.1 10037175 - Psychiatric disorders 10012346 Dependence on opiates LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed) SE (Completed) CZ (Completed) DE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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