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Clinical trials for Opioids

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44336   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    356 result(s) found for: Opioids. Displaying page 1 of 18.
    1  2  3  4  5  6  7  8  9  Next» Last»»
    EudraCT Number: 2008-005181-31 Sponsor Protocol Number: A4091003 Start Date*: 2009-04-29
    Sponsor Name:Pfizer Inc., 235 East 42nd Street, New York, NY 10017
    Full Title: PHASE II RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTICENTER EFFICACY AND SAFETY STUDY OF TANEZUMAB AS ADD-ON THERAPY TO OPIOID MEDICATION IN PATIENTS WITH PAIN DUE TO BONE METASTASES
    Medical condition: PAIN DUE TO BONE METASTASES
    Disease: Version SOC Term Classification Code Term Level
    9.1 10049038 Metastatic bone pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) LV (Completed) SK (Completed) FR (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2020-005123-36 Sponsor Protocol Number: PARASTOP Start Date*: 2021-07-05
    Sponsor Name:Oslo University Hospital
    Full Title: A randomized, double-blind, parallel-group non-inferiority phase III withdrawal trial of paracetamol versus placebo in conjunction with opioids for moderate to severe cancer-related pain
    Medical condition: Adult patients with metastatic cancer disease, cancer-related pain treated with regular strong opioids, receiving paracetamol (1 gram three or four times a day) and with average pain intensity past...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2009-013022-16 Sponsor Protocol Number: ZonMw 80-82100-98-096/11510014 Start Date*: 2009-10-21
    Sponsor Name:Erasmus MC [...]
    1. Erasmus MC
    2. ZonMw
    Full Title: Effecten en bijwerkingen van opioïden: een studie naar de rol van farmacokinetische en farmacogenetische heterogeniteit.
    Medical condition: Nociceptive cancer pain for which strong opioids are needed
    Disease: Version SOC Term Classification Code Term Level
    9.1 10058019 Cancer pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-000197-38 Sponsor Protocol Number: AC15006 Start Date*: 2016-08-04
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: A double blind randomised parallel group trial of paracetamol versus placebo in conjunction with strong opioids for cancer related pain.
    Medical condition: Cancer related pain.
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004867 10069398 Breakthrough cancer pain LLT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10058019 Cancer pain PT
    20.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10058019 Cancer pain PT
    Population Age: Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2007-007610-10 Sponsor Protocol Number: 11500005 Start Date*: 2009-01-13
    Sponsor Name:UMC Utrecht
    Full Title: Prevention of constipation during treatment with opioids: magnesiumoxide versus macrogol/elektrolytes
    Medical condition: Palliative care cancer patients starting with opioids
    Disease: Version SOC Term Classification Code Term Level
    9.1 10010774 Constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Prematurely Ended)
    Trial results: (No results available)
    EudraCT Number: 2006-004071-34 Sponsor Protocol Number: PRG-Opioid-06-/03 Start Date*: 2009-01-14
    Sponsor Name:Queen Mary, University of London (QMUL)
    Full Title: A single centre, parallel group, pilot study to investigate the effect of opioids on immunomarkers using gene expression profiling.
    Medical condition: This study is not looking at any disease process
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2013-001167-22 Sponsor Protocol Number: 43488 Start Date*: 2017-06-29
    Sponsor Name:
    Full Title: Spinal Morphine in laparoscopic gastro-intestinal surgery
    Medical condition: Patients with indications for laparoscopic gastro-intestinal surgery
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-008012-98 Sponsor Protocol Number: sl2008-1 Start Date*: 2009-12-18
    Sponsor Name:Stefan Lundeberg
    Full Title: Pharmacokinetic study of the opioid ketobemidone in neonates after an intravenous administration
    Medical condition: Pain treatment with opioids in children
    Disease:
    Population Age: Newborns, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2012-001849-41 Sponsor Protocol Number: DOX-101 Start Date*: 2012-06-18
    Sponsor Name:Leids Universitair Medisch Centrum (LUMC)
    Full Title: Two-part, Randomized, Placebo-controlled, Repeated Stepped Infusion Dose Study of the Pharmacodynamics of Doxapram when Co-administered with Opioids (Protocol – doxapram-101).
    Medical condition: acute respiratory insufficiency, including such conditions as opioid and anesthetic-induced respiratory depression, post-anesthetic atelectasis, and central apneas (e.g., apnea of prematurity).
    Disease: Version SOC Term Classification Code Term Level
    14.1 10038738 - Respiratory, thoracic and mediastinal disorders 10038738 Respiratory, thoracic and mediastinal disorders SOC
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-005035-26 Sponsor Protocol Number: Methadone study Start Date*: 2005-04-05
    Sponsor Name:Anesthesiology Clinic,Akademiska Sjukhuset, Uppsala
    Full Title: Methadone in chronic non-cancer pain: rotation from other opioids and choice of dose
    Medical condition: Chronic non-cancer pain
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2006-006717-32 Sponsor Protocol Number: 554 Start Date*: 2007-01-31
    Sponsor Name:Stefan Lundeberg
    Full Title: Pharmacokinetic study of the opioid ketobemidone in children and adolescens after intravenous administration
    Medical condition: Pain treatment with opioids in children
    Disease:
    Population Age: Newborns, Infants and toddlers, Children, Under 18 Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: View results
    EudraCT Number: 2009-011862-27 Sponsor Protocol Number: 01-NAB-ZISOP Start Date*: 2009-09-18
    Sponsor Name:ZISOP Zentrum für interdisziplinäre Schmerztherapie Landeskrankenhaus Klagenfurt
    Full Title: Überprufung der wirksamkeit und Sicherheit einer Add-on Therapie mit dem synthetischen Cannabinomimetikum Nabilone bei Patienten mit Tumorschmerz
    Medical condition: Pain related to cancer (solid tumors)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2015-005306-11 Sponsor Protocol Number: SleepRCT_270215 Start Date*: 2016-06-09
    Sponsor Name:St. Olavs Hospital, trondheim University Hospital
    Full Title: Pharmacological treatment of insomnia in palliative care A randomized, double-blind, placebo controlled, parallel-group, multicenter trial investigating the short time effectiveness of zopiclone...
    Medical condition: The overall aim of this clinical trial is to improve the knowledge of the pharmacological treatment of insomnia in patients with advanced cancer who use opioids. Despite the high prevalence of inso...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2022-000408-36 Sponsor Protocol Number: 08440012010002 Start Date*: 2022-10-25
    Sponsor Name:ZonMw
    Full Title: OMAMA-study – prevention of opioid-induced constipation in patients with advanced cancer
    Medical condition: Opioid-induced constipation in patients with advanced cancer, starting with opioids for pain
    Disease: Version SOC Term Classification Code Term Level
    24.0 10017947 - Gastrointestinal disorders 10071128 Opioid induced constipation LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Trial now transitioned)
    Trial results: (No results available)
    EudraCT Number: 2011-001202-99 Sponsor Protocol Number: CNSB015CP01 Start Date*: 2011-10-18
    Sponsor Name:Relevare Pharmaceuticals, Ltd.
    Full Title: A Phase IIb/III, Double-Blind, Placebo-Controlled, Randomized Study Investigating the Safety, Tolerability and Efficacy of Flupirtine as Adjunct to Opioids When Administered to Cancer Subjects Who ...
    Medical condition: Pain with neuropathic features in cancer subjects which is inadequately controlled despite optimized opioid treatment
    Disease: Version SOC Term Classification Code Term Level
    14.0 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps) 10045158 Tumor pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2016-004594-41 Sponsor Protocol Number: 2016-1 Start Date*: 2017-01-13
    Sponsor Name:Jens Børglum
    Full Title: Ultrasound-guided Transmuscular Quadratus Lumborum block for elective caesarean section. A double blind, randomized, placebo controlled trial.
    Medical condition: Postoperative pain and opioid consumption after elective caesarean section.
    Disease: Version SOC Term Classification Code Term Level
    19.1 100000004863 10054711 Postoperative pain LLT
    Population Age: Adults Gender: Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2013-003319-23 Sponsor Protocol Number: SLF_SCMO_0113 Start Date*: 2013-11-07
    Sponsor Name:Fondazione IRCCS Istituto Nazionale dei Tumori
    Full Title: SUBLINGUAL FENTANYL VERSUS SUBCUTANEOUS MORPHINE FOR THE MANAGEMENT OF SEVERE CANCER PAIN EPISODES IN PATIENTS ON OPIOID TREATMENT: A DOUBLE-BLIND RANDOMIZED NON–INFERIORITY TRIAL.
    Medical condition: pain due to cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-004496-10 Sponsor Protocol Number: NRL011-01/2004 Start Date*: 2005-04-05
    Sponsor Name:Norgine International Limited
    Full Title: A Phase 2a double blind, randomised, placebo controlled, two dose study to determine the effect of orally administered methylnaltrexone (MNTX) in preventing post-operative opiate induced constipati...
    Medical condition: Coated MNTX is being developed for the prevention of constipation in patients taking opioids for hip and knee replacement surgery for analgesia (pain relief). This drug is as yet unlicensed for use...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2019-000205-77 Sponsor Protocol Number: KF5503-75 Start Date*: Information not available in EudraCT
    Sponsor Name:Grünenthal GmbH
    Full Title: Open-label investigation of the pharmacokinetic profile, safety, tolerability, and efficacy of multiple administrations of tapentadol oral solution used for treatment of acute pain in children aged...
    Medical condition: Moderate to severe acute pain
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004867 10066714 Acute pain LLT
    Population Age: Children, Under 18 Gender: Male, Female
    Trial protocol: PL (Completed)
    Trial results: View results
    EudraCT Number: 2014-004416-11 Sponsor Protocol Number: TVOC01 Start Date*: 2015-08-25
    Sponsor Name:Modus Therapeutics AB
    Full Title: A Multi-Centre, Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Investigate Efficacy and Safety of Sevuparin Infusion for the Management of Acute Vaso-Occlusive Crisis (VOC) in Subj...
    Medical condition: Acute Vaso-Occlusive Crisis (VOC) in Subjects with Sickle-Cell Disease
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004850 10040644 Sickle cell disease LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: NL (Completed) BE (Completed)
    Trial results: View results
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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