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Clinical trials for Physiological effects

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   44334   clinical trials with a EudraCT protocol, of which   7366   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
    Examples: Cancer AND drug name. Pneumonia AND sponsor name.
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    331 result(s) found for: Physiological effects. Displaying page 1 of 17.
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    EudraCT Number: 2008-000540-14 Sponsor Protocol Number: HIGHCARE Start Date*: 2008-05-20
    Sponsor Name:ISTITUTO AUXOLOGICO ITALIANO
    Full Title: Role of the renin-angiotensin system in the cardiovascular, metabolic, neurologic and respiratory response to hypobaric hypoxia during sustained exposure to high altitude.
    Medical condition: This study is aimed at the investigation of adaptative physiological mechanisms at high altitude and not at the development of new therapeutic indications.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10007541 Cardiac disorders SOC
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-002475-32 Sponsor Protocol Number: 050526 FMS Start Date*: 2005-12-07
    Sponsor Name:Charitè Universitätmeditin Berlin
    Full Title: Pilotstudy about endocrinilogical, peripherphysilogical and painreducing effects of Gamma-hydroxybutyrate in combination with operant-behaviour-therapeutic paintherapy with patients in Fibromyalgia...
    Medical condition: Patients with Fibromyalgia-syndrome
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-010614-30 Sponsor Protocol Number: CH/2007/2746 Start Date*: 2009-05-08
    Sponsor Name:University Hospitals Bristol
    Full Title: Randomised cross-over pilot study to determine the effects of isoflurane and propofol on pulmonary vascular resistance in children with pulmoanry hypertension
    Medical condition: children with pulmonary hypertension
    Disease:
    Population Age: Infants and toddlers, Children, Adolescents, Under 18 Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: View results
    EudraCT Number: 2013-001734-17 Sponsor Protocol Number: FuMA Start Date*: 2014-04-23
    Sponsor Name:University of Rome Foro Italico
    Full Title: Short-term effects of testosterone enhantate and gel on neuro-physiological function
    Medical condition: HYPOGONADISM
    Disease: Version SOC Term Classification Code Term Level
    16.1 10014698 - Endocrine disorders 10058359 Hypogonadism PT
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2016-001455-42 Sponsor Protocol Number: NL56309.091.16 Start Date*: 2016-04-20
    Sponsor Name:Radboud Universitair Medisch Centrum
    Full Title: The influence of metformin and a hypocaloric diet on thyroid radioactive iodide uptake in healthy volunteers: a pilot study
    Medical condition: physiological thyroid function in terms of thyroid iodide uptake and thyroid hormone production knowledge can be extrapolated for treatment of thyroid diseases such as hyperthyroidism and thyroid ...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Completed)
    Trial results: View results
    EudraCT Number: 2004-004823-36 Sponsor Protocol Number: AZ1-2004 Start Date*: 2005-03-03
    Sponsor Name:daacro - diagnostic assessment and clinical research organization
    Full Title: Effects of Alprazolam and Flupentixol on endocrine, autonomic and psychological parameters in the Trier Social Stress Test (TSST)
    Medical condition: 69 healthy male subjects, age 18-45 undergo a laboratory stress test (TSST)
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DE (Completed)
    Trial results: View results
    EudraCT Number: 2015-003962-10 Sponsor Protocol Number: DOA_HO Start Date*: 2015-12-10
    Sponsor Name:Medical University of Vienna
    Full Title: Effects of Hyperoxia on Haemostasis, Inflammation and oxidative Stress
    Medical condition: Effects of hyperoxia on haemostasis, inflammation and reactive oxygen species
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2022-002137-34 Sponsor Protocol Number: SVS.FAM.01 Start Date*: 2022-07-25
    Sponsor Name:Hospital of South West Jutland
    Full Title: Rapid infusion of Ringer's lactate solution at different temperatures and the effects on circulation and perfusion in healthy volunteers – a randomized crossover trial
    Medical condition: Hemodynamic parameters is to be investigated -- comparing cold fluids to body temperature fluids.
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2016-004078-16 Sponsor Protocol Number: DOSCORT20092231 Start Date*: 2020-11-23
    Sponsor Name:Sahlgrenska University Hospital, Gothenburg
    Full Title: A dose-response study of markers of glucocorticoid action (DOSCORT)- A double-blind, randomized, two-period, two-dose, cross-over study in subjects with primary adrenal insufficiency
    Medical condition: Adrenal insufficiency e.g. Addison´s disease
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-002987-26 Sponsor Protocol Number: KOLterbutaline Start Date*: 2011-08-24
    Sponsor Name:Bispebjerg Hospital
    Full Title: Effects of high dose terbutaline on physical performance in patients with chronic obstructive pulmonary disease and acute inflammatory response after exercise
    Medical condition: To investigate the effects of terbutaline on repeated exercise performance in patients with chronic obstructive pulmonary disease (COPD). Furthermore to examine the inflammatory response during and...
    Disease:
    Population Age: Adults, Elderly Gender: Male
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2012-002804-42 Sponsor Protocol Number: Beta2-Mikro Start Date*: 2012-09-10
    Sponsor Name:Bispebjerg Hospital
    Full Title: The effects of high dose beta2-agonists on physical performance in healthy male subjects
    Medical condition: No medical condition will be investigated. To examine the effects of beta2-agonists on aerobic and anaerobic exercise performance.
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: DK (Prematurely Ended)
    Trial results: Removed from public view
    EudraCT Number: 2011-000037-36 Sponsor Protocol Number: KLF/K/010710 Start Date*: Information not available in EudraCT
    Sponsor Name:MCM Klosterfrau GmbH & Co. KG
    Full Title: Open label clinical trial to investigate the physiological effects on sleep of Nervenruh Baldrian Forte 600 in patients with primary insomnia
    Medical condition: Primary (psychophysiologic) insomnia
    Disease: Version SOC Term Classification Code Term Level
    13.1 10037175 - Psychiatric disorders 10036701 Primary insomnia LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: DE (Ongoing)
    Trial results: View results
    EudraCT Number: 2018-003515-22 Sponsor Protocol Number: SURF Start Date*: 2018-11-29
    Sponsor Name:Leiden University Medical Center
    Full Title: Respiratory effects of tapentadol and oxycodone assessed by pharmacokinetic-pharmacodynamic and response surface modeling in healthy volunteers
    Medical condition: Chronic pain
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005452-26 Sponsor Protocol Number: SMR-2728 Start Date*: 2015-11-19
    Sponsor Name:OptiNose AS
    Full Title: A randomized, placebo controlled, double-blind, double-dummy, 3-period cross-over study in adult patients with autism spectrum disorders evaluating cognitive response, eye-gaze, and heart rate vari...
    Medical condition: Autism spectrum disorder
    Disease: Version SOC Term Classification Code Term Level
    17.1 10037175 - Psychiatric disorders 10063844 Autism spectrum disorder PT
    Population Age: Adults Gender: Male
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-004860-31 Sponsor Protocol Number: 2.2.20110919 Start Date*: 2011-10-27
    Sponsor Name:Medical University of Vienna
    Full Title: Multimodal Assessment of Neurobiological Markers for Psychiatric Disorders
    Medical condition: Major Depressive Disorder Anxiety Disorder
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2016-002819-18 Sponsor Protocol Number: WADA2016Sal Start Date*: 2016-12-14
    Sponsor Name:Bispebjerg University Hospital
    Full Title: Pharmacological effects of acute and accumulated salbutamol in relation to doping analysis
    Medical condition: Pharmacological effects of acute and accumulated salbutamol in relation to doping analysis
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2015-005056-96 Sponsor Protocol Number: TRAWADA2015 Start Date*: 2016-05-31
    Sponsor Name:Daniel Sanabria Lucena
    Full Title: Use of tramadol in healthy volunteers. Effects on physical performance and sustained attention in cycling.
    Medical condition: Sport doping
    Disease: Version SOC Term Classification Code Term Level
    18.1 100000004873 10076471 Drug doping LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Completed)
    Trial results: View results
    EudraCT Number: 2019-004144-29 Sponsor Protocol Number: lbnp_methoxy_fent_2019 Start Date*: 2020-06-24
    Sponsor Name:Oslo University Hospital
    Full Title: Methoxyflurane and fentanyl in hypovolemia induced by lower body negative pressure in healthy volunteers; A randomized, placebo-controlled crossover study
    Medical condition: The study will investigate and compare the responses to experimental hypovolemia of methoxyflurane, fentanyl and placebo (NaCl) using the "lower body negative pressure" (LBNP)-model .
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: NO (Completed)
    Trial results: View results
    EudraCT Number: 2019-000958-56 Sponsor Protocol Number: 2019/375 Start Date*: 2019-08-16
    Sponsor Name:Helse Fonna
    Full Title: “Haemodynamic stability during induction of general anesthesia with propofol and remifentanil: A randomized, controlled, double-blind study comparing low vs high propofol doses.”
    Medical condition: In daily clinical work we observe a hypotensive effect and a reduction in HR when induction of general anesthesia is performed using propofol and remifentanil. It is difficult to differentiate the ...
    Disease:
    Population Age: Adults Gender: Female
    Trial protocol: NO (Completed)
    Trial results: (No results available)
    EudraCT Number: 2010-020357-14 Sponsor Protocol Number: CCFM154/310 Start Date*: 2011-05-16
    Sponsor Name:FONDAZIONE MONZINO CENTRO CARDIOLOGICO
    Full Title: EFFECTS OF BETA 2 RECEPTOR BLOCKADE ON PULMONARY FUNCTION IN A HUMAN MODEL OF ACUTE HYDRIC OVERLOAD
    Medical condition: BETA BLOCKADE AND LUNG FUNCTION
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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