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Clinical trials for Reductase

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    70 result(s) found for: Reductase. Displaying page 1 of 4.
    1  2  3  4  Next»
    EudraCT Number: 2006-004686-34 Sponsor Protocol Number: Evaluation Statin Therapy Start Date*: 2007-02-27
    Sponsor Name:Karolinska University Hospital
    Full Title: Evaluation of Statin Therapy- Safety, Effect and Toxicity Mechanisms.
    Medical condition: Frequency of side effects in patients treated with HMG CoA reductase inhibitors.
    Disease: Version SOC Term Classification Code Term Level
    8.1 10058108 Dyslipidaemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-006234-34 Sponsor Protocol Number: CD07/8396 Start Date*: 2008-08-18
    Sponsor Name:University of Leeds
    Full Title: 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: endothelial and endothelial progenitor cell function in men
    Medical condition: Objectives:To investigate whether statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) improve endothelial dysfunction in healthy volunteers (men). Endothelial dysfunction is an ear...
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-005143-28 Sponsor Protocol Number: MED.RES.HOS.2006.03.LP Start Date*: 2006-12-06
    Sponsor Name:Medicinsk Forskning
    Full Title: Effects of HMG-CoA-reductase inhibition (atorvastatin) on renal sodium excretion, renal hemodynamics, tubular function and vasoactive hormones in healthy subjects under diet with normal and high so...
    Medical condition: Healthy volunteer trial
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-015955-25 Sponsor Protocol Number: 1/09 Start Date*: 2010-02-01
    Sponsor Name:University Hospital
    Full Title: INDIVIDUAL 5-FLUOROURACIL DOSE INDIVIDUALIZATION IN PATIENTS WITH COLORECTAL CANCER
    Medical condition: colorectal cancer
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed)
    Trial results: View results
    EudraCT Number: 2011-001529-26 Sponsor Protocol Number: 20090159 Start Date*: 2011-07-15
    Sponsor Name:Amgen Inc
    Full Title: A Randomized, Multicenter Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C, Compared with Ezetimibe, in Hypercholesterolemic Subjects Unable to Tolerate an Effective Dose of a HMG-Co...
    Medical condition: Hypercholesterolaemia
    Disease: Version SOC Term Classification Code Term Level
    13.1 10027433 - Metabolism and nutrition disorders 10020603 Hypercholesterolaemia PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) BE (Completed) SE (Completed) DK (Completed) FI (Completed)
    Trial results: View results
    EudraCT Number: 2005-004876-19 Sponsor Protocol Number: 01-05-TL-475-021 Start Date*: 2006-02-13
    Sponsor Name:Takeda Europe R&D Centre Ltd
    Full Title: A Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of TAK-475 100 mg or Placebo When Co-Administered With High Dose Statin Therapy in Subjects With Primary Hypercholesterolemia
    Medical condition: Treatment of patients with primary hypercholesterolemia currently taking atorvastatin (80mg), simvastatin (80mg) or rosuvastatin (40mg)
    Disease: Version SOC Term Classification Code Term Level
    8 10058108 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) ES (Completed) SE (Prematurely Ended) NO (Completed) FI (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-011448-20 Sponsor Protocol Number: 2008.11.007 Start Date*: 2009-06-22
    Sponsor Name:Dutch Diabetes Research Foundation
    Full Title: Hyperoxic exercise training as an innovative therapy to improve metabolic control, endothelial dysfunction and physical fitness in deconditioned type 2 diabetes patients
    Medical condition: insulin resistance, endothelial dysfunction, cardiovascular fitness, lipid metabolism and glycemic control in deconditioned non-insulin dependent type 2 diabetes patients
    Disease: Version SOC Term Classification Code Term Level
    9.1 10050322 Oxygen supplementation PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-013622-17 Sponsor Protocol Number: REMEDY Start Date*: 2009-10-20
    Sponsor Name:CARDIOLOGIA UNIVERSITARIA - OSPEDALE CLINICIZZATO SS. ANNUNZIATA - VIA DEI VESTINI - 66013 CHIETI
    Full Title: ROSUVASTATIN FOR REDUCTION OF MYOCARDIAL DAMAGE AND SYSTEMIC INFLAMMATION DURING CORONARY ANGIOPLASTY - The REMEDY Study
    Medical condition: In patients with suspected stable CAD candidates to PCI
    Disease: Version SOC Term Classification Code Term Level
    12.1 10011085 Ischaemic coronary artery disorders HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2012-002436-82 Sponsor Protocol Number: EC11-441 Start Date*: 2012-12-13
    Sponsor Name:Isabel Pinilla Lozano
    Full Title: Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa
    Medical condition: To evaluate the sleep quality in patients with Retinitis Pigmentosa
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2008-006782-83 Sponsor Protocol Number: EC08/00230 Start Date*: 2013-09-24
    Sponsor Name:Hospital Universitario Virgen de las Nieves
    Full Title: Prevention MODS by modulating the inflammatory response through melatonin administration in surgical patients with severe sepsis.
    Medical condition: Septic patients of abdominal surgery
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2014-005508-62 Sponsor Protocol Number: TRINACRIA Start Date*: 2015-10-08
    Sponsor Name:ISTITUTI FISIOTERAPICI OSPITALIERI
    Full Title: A phase II, randomized, non-comparative, pre-surgical study of atorvastatin or observation in Ki-67 positive, TAZ-expressing early breast cancer patients
    Medical condition: Early breast cancer
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10006175 Breast adenocarcinoma stage I LLT
    20.0 100000004864 10006176 Breast adenocarcinoma stage II LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-001007-18 Sponsor Protocol Number: 2989 Start Date*: 2005-06-03
    Sponsor Name:Royal Victoria Infirmary
    Full Title: Reversal of warfarin anticoagulation with oral vitamin K: towards a better management of over-anticoagulation
    Medical condition: Patients with thromboembolic disorders are anticogulated with warfarin. However excessive over-anticoagulation can increase the patient risk of bleeding. Oral vitamin K is routinely used for revers...
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2009-017060-17 Sponsor Protocol Number: STIMULATE1.0 Start Date*: 2009-12-10
    Sponsor Name:Academic Medical Center
    Full Title: STIMULATE study: Statins influence on Minrin upregulation of von Willebrand factor and factor VIII
    Medical condition: Type 1 von Willebrand disease and mild hemophilia A
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2005-003041-14 Sponsor Protocol Number: 565 Start Date*: 2005-09-20
    Sponsor Name:Department of Clinical Pharmacology, Medical University of Vienna
    Full Title: Anti-inflammatory effect of statins in the human endotoxin model
    Medical condition: Healthy volunteers are tested in an endotoxemia model
    Disease:
    Population Age: Adults Gender: Male
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2004-002535-12 Sponsor Protocol Number: kimcl2004-08 Start Date*: 2004-11-19
    Sponsor Name:Clinical Institute of Medical and Chemical Laboratory Diagnostics Graz
    Full Title: Fluvastatin 80 mg ret. vs combination with ezetimib 10 mg
    Medical condition: elevated LDL-C
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-002454-37 Sponsor Protocol Number: RGHT000392 Start Date*: 2007-07-20
    Sponsor Name:The Royal Group Hospitals Trust
    Full Title: Prevention by HMGCoA reductase inhibition of ALI associated with one lung ventilation following oesophagectomy by a Reduction of Pulmonary vascular dysfunction and inflammation (Prevention-HARP)
    Medical condition: Acute lung injury (ALI)
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-003539-56 Sponsor Protocol Number: 1.01 Start Date*: 2006-11-10
    Sponsor Name:Medical University of Vienna, Department of Internal Medicine IV
    Full Title: Simvastatin in patients with septic shock
    Medical condition: Septic shock
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-006451-52 Sponsor Protocol Number: 4474 Start Date*: 2009-01-27
    Sponsor Name:Newcastle upon Tyne Hospitals NHS Foundation Trust
    Full Title: An investigation of the association between vitamin K intake, vitamin K epoxide reductase subunit (VKORC1) genotype and anticoagulation response to warfarin
    Medical condition: Patients will be recruited who are receiving long term warfarin therapy for the treatment or prevention of venous or arterial thrombosis or embolism
    Disease: Version SOC Term Classification Code Term Level
    9.1 10043566 Thromboembolism LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2005-000691-41 Sponsor Protocol Number: AR001 Start Date*: 2005-04-11
    Sponsor Name:Greater Glasgow Health Board, North Glasgow University Hospitals Division
    Full Title: Randomised controlled trial to evaluate the effect of statins on asthma control of patients with chronic asthma.
    Medical condition: Chronic Asthma
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2017-000095-28 Sponsor Protocol Number: H3E-MC-JMHW Start Date*: 2017-03-02
    Sponsor Name:Eli Lilly and Company
    Full Title: A Phase II Study of Pemetrexed in Children with Recurrent Malignancies
    Medical condition: Recurrent Malignancies (recurrent solid tumors): Target tumor types were osteosarcoma, Ewing sarcoma/peripheral PNET, rhabdomyosarcoma, neuroblastoma (measurable disease), neuroblastoma (metaiodob...
    Disease:
    Population Age: Children, Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: Outside EU/EEA
    Trial results: View results
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    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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